Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/867 |
Resumo: | The uploaded article version is the Epub Ahead of Print version of the article, posted online 8 May 2018. It has been submitted to peer-review. |
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Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesisCancerhuman cancerOrganellesCentrosome amplificationp53The uploaded article version is the Epub Ahead of Print version of the article, posted online 8 May 2018. It has been submitted to peer-review.The deposited article version contains attached the supplementary materials within the pdf.Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics of such abnormalities in human cancer are not known. In this study, we examined centrosomes in Barrett's esophagus tumorigenesis, a well-characterized multistep pathway of progression, from the premalignant condition to the metastatic disease. This human cancer model allows the study of sequential steps of progression within the same patient and has representative cell lines from all stages of disease. Remarkably, centrosome amplification was detected as early as the premalignant condition and was significantly expanded in dysplasia. It was then present throughout malignant transformation both in adenocarcinoma and metastasis. The early expansion of centrosome amplification correlated with and was dependent on loss of function of the tumor suppressor p53 both through loss of wild-type expression and hotspot mutations. Our work shows that centrosome amplification in human tumorigenesis can occur before transformation, being repressed by p53. These findings suggest centrosome amplification in humans can contribute to tumor initiation and progression.Fundação para a Ciência e a Tecnologia–Harvard Medical School Program Portugal grant: (HMSP-CT/SAU-ICT/0075/2009); Liga Portuguesa Contra o Cancro; European Molecular Biology Organization Installation; Sociedade Portuguesa de Gastroenterologia.Rockefeller University PressARCALopes, Carla A.M.Mesquita, MartaCunha, Ana IsabelCardoso, JoanaCarapeta, SaraLaranjeira, CátiaPinto, António E.Pereira-Leal, José B.Dias-Pereira, AntónioBettencourt-Dias, MónicaChaves, Paula2018-12-01T01:30:09Z2018-052018-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/867engCarla A.M. Lopes, Marta Mesquita, Ana Isabel Cunha, Joana Cardoso, Sara Carapeta, Cátia Laranjeira, António E. Pinto, José B. Pereira-Leal, António Dias-Pereira, Mónica Bettencourt-Dias, Paula Chaves (2018). Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis.J Cell Biol May 2018, jcb.201711191; DOI: 10.1083/jcb.20171119110.1083/jcb.201711191info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:16Zoai:arca.igc.gulbenkian.pt:10400.7/867Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:04.794482Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis |
| title |
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis |
| spellingShingle |
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis Lopes, Carla A.M. Cancer human cancer Organelles Centrosome amplification p53 |
| title_short |
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis |
| title_full |
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis |
| title_fullStr |
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis |
| title_full_unstemmed |
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis |
| title_sort |
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis |
| author |
Lopes, Carla A.M. |
| author_facet |
Lopes, Carla A.M. Mesquita, Marta Cunha, Ana Isabel Cardoso, Joana Carapeta, Sara Laranjeira, Cátia Pinto, António E. Pereira-Leal, José B. Dias-Pereira, António Bettencourt-Dias, Mónica Chaves, Paula |
| author_role |
author |
| author2 |
Mesquita, Marta Cunha, Ana Isabel Cardoso, Joana Carapeta, Sara Laranjeira, Cátia Pinto, António E. Pereira-Leal, José B. Dias-Pereira, António Bettencourt-Dias, Mónica Chaves, Paula |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Lopes, Carla A.M. Mesquita, Marta Cunha, Ana Isabel Cardoso, Joana Carapeta, Sara Laranjeira, Cátia Pinto, António E. Pereira-Leal, José B. Dias-Pereira, António Bettencourt-Dias, Mónica Chaves, Paula |
| dc.subject.por.fl_str_mv |
Cancer human cancer Organelles Centrosome amplification p53 |
| topic |
Cancer human cancer Organelles Centrosome amplification p53 |
| description |
The uploaded article version is the Epub Ahead of Print version of the article, posted online 8 May 2018. It has been submitted to peer-review. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-12-01T01:30:09Z 2018-05 2018-05-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/867 |
| url |
http://hdl.handle.net/10400.7/867 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Carla A.M. Lopes, Marta Mesquita, Ana Isabel Cunha, Joana Cardoso, Sara Carapeta, Cátia Laranjeira, António E. Pinto, José B. Pereira-Leal, António Dias-Pereira, Mónica Bettencourt-Dias, Paula Chaves (2018). Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis.J Cell Biol May 2018, jcb.201711191; DOI: 10.1083/jcb.201711191 10.1083/jcb.201711191 |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Rockefeller University Press |
| publisher.none.fl_str_mv |
Rockefeller University Press |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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