Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Jorge
Data de Publicação: 2022
Outros Autores: Milheiro Silva, Tiago, Garcia, Ana Margarida, Soares, Eugénia, Brito, Maria João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.25754/pjp.2022.21819
Resumo: Acute chest syndrome (ACS) is a life-threatening complication in sickle cell disease (SCD). Infections are frequently implied and like other viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be a trigger. Additionally, due to their inflammatory status, they are considered a high-risk group for severe coronavirus disease 2019 (COVID-19). Pneumonia and ACS share clinical, laboratory and radiological features and may overlap, which makes their differential diagnosis especially challenging. We describe a case of an adolescent with homozygous SCD (HbSS) that developed ACS in the context of COVID-19. With it, we intend to bring awareness to the potential role of imaging in the differential diagnosis and in establishing the best approach for the patient. Chest CT findings were suggestive of an alternative diagnosis to COVID-19 pneumonia and blood transfusion, fluid therapy, analgesics, antibiotics were administered with favorable outcome.
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spelling Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19EnglishCase reportsAcute chest syndrome (ACS) is a life-threatening complication in sickle cell disease (SCD). Infections are frequently implied and like other viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be a trigger. Additionally, due to their inflammatory status, they are considered a high-risk group for severe coronavirus disease 2019 (COVID-19). Pneumonia and ACS share clinical, laboratory and radiological features and may overlap, which makes their differential diagnosis especially challenging. We describe a case of an adolescent with homozygous SCD (HbSS) that developed ACS in the context of COVID-19. With it, we intend to bring awareness to the potential role of imaging in the differential diagnosis and in establishing the best approach for the patient. Chest CT findings were suggestive of an alternative diagnosis to COVID-19 pneumonia and blood transfusion, fluid therapy, analgesics, antibiotics were administered with favorable outcome.A síndrome torácica aguda (STA) é uma complicação ameaçadora de vida na doença de células falciformes (DCF). As infeções estão frequentemente implicadas e, tal como outros vírus, o severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pode provocar STA. Adicionalmente, devido ao seu estado hiperinflamatório, estes pacientes são considerados de alto risco para coronavirus disease 2019 (COVID-19) grave. A pneumonia e a STA partilham semelhanças a nível clínico, laboratorial e imagiológico e podem sobrepor-se, o que pode complicar o seu diagnóstico diferencial. Os autores descrevem um caso de um adolescente com DCF em homozigotia (HbSS) que desenvolveu STA em contexto de COVID-19. Através dele, procuramos alertar para o potencial papel da imagem no diagnóstico diferencial destas entidades e na orientação terapêutica destes doentes. Neste caso, os achados na TC torácica foram sugestivos de um diagnóstico alternativo à pneumonia COVID-19 e a intervenção terapêutica com transfusão sanguínea, normohidratação, analgesia e antibioticoterapia conduziu à evolução favorável do caso.Sociedade Portuguesa de Pediatria2022-01-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.25754/pjp.2022.21819eng2184-44532184-3333Rodrigues, JorgeMilheiro Silva, TiagoGarcia, Ana MargaridaSoares, EugéniaBrito, Maria Joãoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T02:58:15ZPortal AgregadorONG
dc.title.none.fl_str_mv Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19
English
title Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19
spellingShingle Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19
Rodrigues, Jorge
Case reports
title_short Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19
title_full Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19
title_fullStr Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19
title_full_unstemmed Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19
title_sort Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19
author Rodrigues, Jorge
author_facet Rodrigues, Jorge
Milheiro Silva, Tiago
Garcia, Ana Margarida
Soares, Eugénia
Brito, Maria João
author_role author
author2 Milheiro Silva, Tiago
Garcia, Ana Margarida
Soares, Eugénia
Brito, Maria João
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Jorge
Milheiro Silva, Tiago
Garcia, Ana Margarida
Soares, Eugénia
Brito, Maria João
dc.subject.por.fl_str_mv Case reports
topic Case reports
description Acute chest syndrome (ACS) is a life-threatening complication in sickle cell disease (SCD). Infections are frequently implied and like other viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be a trigger. Additionally, due to their inflammatory status, they are considered a high-risk group for severe coronavirus disease 2019 (COVID-19). Pneumonia and ACS share clinical, laboratory and radiological features and may overlap, which makes their differential diagnosis especially challenging. We describe a case of an adolescent with homozygous SCD (HbSS) that developed ACS in the context of COVID-19. With it, we intend to bring awareness to the potential role of imaging in the differential diagnosis and in establishing the best approach for the patient. Chest CT findings were suggestive of an alternative diagnosis to COVID-19 pneumonia and blood transfusion, fluid therapy, analgesics, antibiotics were administered with favorable outcome.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-24
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.25754/pjp.2022.21819
url https://doi.org/10.25754/pjp.2022.21819
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2184-4453
2184-3333
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Pediatria
publisher.none.fl_str_mv Sociedade Portuguesa de Pediatria
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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