Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case Report

Detalhes bibliográficos
Autor(a) principal: Teixeira, Sofia
Data de Publicação: 2023
Outros Autores: Meira, Dália, Rothwell, Renata
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.48560/rspo.29824
Resumo: Our objective is to report a case of bilateral acute glaucoma associated with hydrochlorothi-azide-induced hyponatremia.   An 83-year-old female patient, with arterial hypertension history, presented with severe ocular pain and decreased vision in both eyes, associated with headache, nausea and vomiting. On examination, visual acuity was counting fingers in both eyes. Biomicroscopy showed ciliary hyperemia, marked corneal edema and shallow anterior chamber. Intraocular pressure (IOP) was 59/68 mmHg. Gonioscopy revealed bilateral angle closure and UBM ciliary body effusion. Antihypertensive eye drops and intravenous mannitol were started. Blood tests revealed profound hyponatremia and hypochloremia. After electrolyte stability, laser iridoplasty was performed in both eyes, and previous hydrochlorothiazide prescription was suspended. Thereafter, progressive clinic improvement was verified, with IOP normalization. Bilateral acute angle closure has been associated with sulfonamide derivative medications. The development of bilateral ciliary effusions and angle closure potentially due to hydrochloro-thiazide-induced-hyponatremia, had been reported only once in literature.
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spelling Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case ReportHiponatrémia-Induzida-por-Hidroclorotiazida: Um Caso Clínico de Glaucoma Agudo de Ângulo Fechado BilateralCasos ClínicosOur objective is to report a case of bilateral acute glaucoma associated with hydrochlorothi-azide-induced hyponatremia.   An 83-year-old female patient, with arterial hypertension history, presented with severe ocular pain and decreased vision in both eyes, associated with headache, nausea and vomiting. On examination, visual acuity was counting fingers in both eyes. Biomicroscopy showed ciliary hyperemia, marked corneal edema and shallow anterior chamber. Intraocular pressure (IOP) was 59/68 mmHg. Gonioscopy revealed bilateral angle closure and UBM ciliary body effusion. Antihypertensive eye drops and intravenous mannitol were started. Blood tests revealed profound hyponatremia and hypochloremia. After electrolyte stability, laser iridoplasty was performed in both eyes, and previous hydrochlorothiazide prescription was suspended. Thereafter, progressive clinic improvement was verified, with IOP normalization. Bilateral acute angle closure has been associated with sulfonamide derivative medications. The development of bilateral ciliary effusions and angle closure potentially due to hydrochloro-thiazide-induced-hyponatremia, had been reported only once in literature.O nosso objetivo é relatar um caso de glaucoma agudo bilateral associado à hiponatremia induzida por hidroclorotiazida. Paciente do sexo feminino, 83 anos, com antecedentes de hipertensão arterial, apresenta dor ocular intensa e diminuição da visão em ambos os olhos, associada a cefaleia, náuseas e vômitos. Ao exame físico, apresentava acuidade visual de conta dedos em ambos os olhos. A biomicroscopia revelou hiperemia ciliar, edema corneano acentuado e câmara anterior plana. A pressão intraocular (PIO) era de 59/68 mmHg. A gonioscopia mostrou ângulo fechado bilateralmente e a UBM efusão do corpo ciliar. Foram iniciados colírios anti-hipertensivos e manitol endovenoso. O estudo analítico revelou hiponatremia profunda e hipocloremia. Após estabilidade eletrolítica, foi realizada iridoplastia laser bilateral, sendo suspensa a prescrição prévia de hidroclorotiazida. A partir daí, verificou-se melhora clínica progressiva, com normalização da PIO. O encerramento de ângulo agudo bilateral tem sido associado a medicamentos derivados de sulfonamidas. O desenvolvimento de efusão ciliar bilateral e encerramento do ângulo, potencialmente devido à hiponatremia-induzida-pela-hidroclorotiazida, foi relatado uma única vez na literatura.Ajnet2023-12-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporthttps://doi.org/10.48560/rspo.29824eng1646-69501646-6950Teixeira, SofiaMeira, DáliaRothwell, Renatainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-04T20:30:33Zoai:ojs.revistas.rcaap.pt:article/29824Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:30:08.221587Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case Report
Hiponatrémia-Induzida-por-Hidroclorotiazida: Um Caso Clínico de Glaucoma Agudo de Ângulo Fechado Bilateral
title Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case Report
spellingShingle Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case Report
Teixeira, Sofia
Casos Clínicos
title_short Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case Report
title_full Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case Report
title_fullStr Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case Report
title_full_unstemmed Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case Report
title_sort Hydrochlorothiazide-Induced Hyponatremia: A Bilateral Acute Angle Closure Glaucoma Case Report
author Teixeira, Sofia
author_facet Teixeira, Sofia
Meira, Dália
Rothwell, Renata
author_role author
author2 Meira, Dália
Rothwell, Renata
author2_role author
author
dc.contributor.author.fl_str_mv Teixeira, Sofia
Meira, Dália
Rothwell, Renata
dc.subject.por.fl_str_mv Casos Clínicos
topic Casos Clínicos
description Our objective is to report a case of bilateral acute glaucoma associated with hydrochlorothi-azide-induced hyponatremia.   An 83-year-old female patient, with arterial hypertension history, presented with severe ocular pain and decreased vision in both eyes, associated with headache, nausea and vomiting. On examination, visual acuity was counting fingers in both eyes. Biomicroscopy showed ciliary hyperemia, marked corneal edema and shallow anterior chamber. Intraocular pressure (IOP) was 59/68 mmHg. Gonioscopy revealed bilateral angle closure and UBM ciliary body effusion. Antihypertensive eye drops and intravenous mannitol were started. Blood tests revealed profound hyponatremia and hypochloremia. After electrolyte stability, laser iridoplasty was performed in both eyes, and previous hydrochlorothiazide prescription was suspended. Thereafter, progressive clinic improvement was verified, with IOP normalization. Bilateral acute angle closure has been associated with sulfonamide derivative medications. The development of bilateral ciliary effusions and angle closure potentially due to hydrochloro-thiazide-induced-hyponatremia, had been reported only once in literature.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-29
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.48560/rspo.29824
url https://doi.org/10.48560/rspo.29824
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1646-6950
1646-6950
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Ajnet
publisher.none.fl_str_mv Ajnet
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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