Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial area
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/62519 |
Resumo: | In the present study, trace elements (TE) levels were evaluated in scalp hair along the continuum from healthy subjects (HS) to patients suffering from subjective memory concerns (SMC), and/or mild cognitive impairment (MCI), and those with already installed dementia (DEM) in order to: (i) assess the effects of environmental and lifestyle factors on TE concentrations and (ii) evaluate the analyzed elements as possible diagnostic biomarkers for the disease. The study involved 79 mainly permanent residents, >55 years old, from the city of Estarreja (northern Portugal), a former industrial area. The health status of the participants was assessed by means of a complete socio-demographic questionnaire and through cognitive screening tests, namely the Mini-Mental State Examination (MMSE). The test scores were categorized and used in the statistical analysis. Hair samples were collected and analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) ICP-MS for selected TE. Dementia appears to be associated with higher age, the female gender, lower education level, and longer residence time in the study area. In addition, most of the participants diagnosed with dementia frequently consume home-grown foodstuffs, some irrigated with contaminated well water. The calculation of the TE enrichment factors of soil samples collected in kitchen gardens/small farms in the vicinity of the Estarreja Chemical Complex (ECC) reinforces the degree of Hg soil contamination in the area, due to anthropogenic sources that can be a source for the population Hg exposure route among others. Mercury levels in hair differed significantly between the four individual groups (HS, SMC, MCI, and DEM), increasing from healthy to dementia participants. Improved diagnostic results can be obtained using hair TE signatures coupled with MMSE scores. This strategy may prove useful for predictive diagnosis in population screening for cognitive impairment. |
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Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial areaexposuretrace elementscognitive impairmentmercuryScience & TechnologyIn the present study, trace elements (TE) levels were evaluated in scalp hair along the continuum from healthy subjects (HS) to patients suffering from subjective memory concerns (SMC), and/or mild cognitive impairment (MCI), and those with already installed dementia (DEM) in order to: (i) assess the effects of environmental and lifestyle factors on TE concentrations and (ii) evaluate the analyzed elements as possible diagnostic biomarkers for the disease. The study involved 79 mainly permanent residents, >55 years old, from the city of Estarreja (northern Portugal), a former industrial area. The health status of the participants was assessed by means of a complete socio-demographic questionnaire and through cognitive screening tests, namely the Mini-Mental State Examination (MMSE). The test scores were categorized and used in the statistical analysis. Hair samples were collected and analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) ICP-MS for selected TE. Dementia appears to be associated with higher age, the female gender, lower education level, and longer residence time in the study area. In addition, most of the participants diagnosed with dementia frequently consume home-grown foodstuffs, some irrigated with contaminated well water. The calculation of the TE enrichment factors of soil samples collected in kitchen gardens/small farms in the vicinity of the Estarreja Chemical Complex (ECC) reinforces the degree of Hg soil contamination in the area, due to anthropogenic sources that can be a source for the population Hg exposure route among others. Mercury levels in hair differed significantly between the four individual groups (HS, SMC, MCI, and DEM), increasing from healthy to dementia participants. Improved diagnostic results can be obtained using hair TE signatures coupled with MMSE scores. This strategy may prove useful for predictive diagnosis in population screening for cognitive impairment.Funding for this research was provided by the Projects SFRH/BPD/71030/2010, Project UID/GEO/04035/2019 (GeoBioTec Research Centre) financed by FCT – Fundação para a Ciência e Tecnologia and by the Labex DRIIHM, Réseau des Observatoires Hommes-Millieux–Centre National de la Recherche Scientifique (ROHM–CNRS) and OHMI-Estarreja. We thank also the participants for taking part in this research and the local private institutions of social solidarity for their collaboration (Santa Casa Misericórdia de Estarreja, Associação Humanitária de Salreu, Centro Paroquial Social São Tomé de Canelas, Centro Paroquial Social Avanca, Fundação Cónego Filipe Figueiredo Beduído and Centro Paroquial de Pardilhó). The manuscript benefited from careful and constructive reviews by three anonymous reviewers.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoCabral Pinto, Marina M. S.Marinho Reis, A. PaulaAlmeida, AgostinhoPinto, EdgarNeves, OrquídiaInácio, ManuelaGerardo, BiancaFreitas, SandraSimões, Mário R.Dinis, Pedro A.Diniz, LuísaFerreira da Silva, EduardoMoreira, Paula I.2019-11-182019-11-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62519engCabral Pinto, M.M.S.; Marinho-Reis, P.; Almeida, A.; Pinto, E.; Neves, O.; Inácio, M.; Gerardo, B.; Freitas, S.; Simões, M.R.; Dinis, P.A.; Diniz, L.; Ferreira da Silva, E.; Moreira, P.I. Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area. Int. J. Environ. Res. Public Health 2019, 16, 4560.1661-78271660-460110.3390/ijerph1622456031752166https://www.mdpi.com/1660-4601/16/22/4560info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:45Zoai:repositorium.sdum.uminho.pt:1822/62519Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:15:05.519450Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial area |
title |
Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial area |
spellingShingle |
Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial area Cabral Pinto, Marina M. S. exposure trace elements cognitive impairment mercury Science & Technology |
title_short |
Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial area |
title_full |
Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial area |
title_fullStr |
Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial area |
title_full_unstemmed |
Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial area |
title_sort |
Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the Estarreja industrial area |
author |
Cabral Pinto, Marina M. S. |
author_facet |
Cabral Pinto, Marina M. S. Marinho Reis, A. Paula Almeida, Agostinho Pinto, Edgar Neves, Orquídia Inácio, Manuela Gerardo, Bianca Freitas, Sandra Simões, Mário R. Dinis, Pedro A. Diniz, Luísa Ferreira da Silva, Eduardo Moreira, Paula I. |
author_role |
author |
author2 |
Marinho Reis, A. Paula Almeida, Agostinho Pinto, Edgar Neves, Orquídia Inácio, Manuela Gerardo, Bianca Freitas, Sandra Simões, Mário R. Dinis, Pedro A. Diniz, Luísa Ferreira da Silva, Eduardo Moreira, Paula I. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Cabral Pinto, Marina M. S. Marinho Reis, A. Paula Almeida, Agostinho Pinto, Edgar Neves, Orquídia Inácio, Manuela Gerardo, Bianca Freitas, Sandra Simões, Mário R. Dinis, Pedro A. Diniz, Luísa Ferreira da Silva, Eduardo Moreira, Paula I. |
dc.subject.por.fl_str_mv |
exposure trace elements cognitive impairment mercury Science & Technology |
topic |
exposure trace elements cognitive impairment mercury Science & Technology |
description |
In the present study, trace elements (TE) levels were evaluated in scalp hair along the continuum from healthy subjects (HS) to patients suffering from subjective memory concerns (SMC), and/or mild cognitive impairment (MCI), and those with already installed dementia (DEM) in order to: (i) assess the effects of environmental and lifestyle factors on TE concentrations and (ii) evaluate the analyzed elements as possible diagnostic biomarkers for the disease. The study involved 79 mainly permanent residents, >55 years old, from the city of Estarreja (northern Portugal), a former industrial area. The health status of the participants was assessed by means of a complete socio-demographic questionnaire and through cognitive screening tests, namely the Mini-Mental State Examination (MMSE). The test scores were categorized and used in the statistical analysis. Hair samples were collected and analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) ICP-MS for selected TE. Dementia appears to be associated with higher age, the female gender, lower education level, and longer residence time in the study area. In addition, most of the participants diagnosed with dementia frequently consume home-grown foodstuffs, some irrigated with contaminated well water. The calculation of the TE enrichment factors of soil samples collected in kitchen gardens/small farms in the vicinity of the Estarreja Chemical Complex (ECC) reinforces the degree of Hg soil contamination in the area, due to anthropogenic sources that can be a source for the population Hg exposure route among others. Mercury levels in hair differed significantly between the four individual groups (HS, SMC, MCI, and DEM), increasing from healthy to dementia participants. Improved diagnostic results can be obtained using hair TE signatures coupled with MMSE scores. This strategy may prove useful for predictive diagnosis in population screening for cognitive impairment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-18 2019-11-18T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/62519 |
url |
http://hdl.handle.net/1822/62519 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cabral Pinto, M.M.S.; Marinho-Reis, P.; Almeida, A.; Pinto, E.; Neves, O.; Inácio, M.; Gerardo, B.; Freitas, S.; Simões, M.R.; Dinis, P.A.; Diniz, L.; Ferreira da Silva, E.; Moreira, P.I. Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area. Int. J. Environ. Res. Public Health 2019, 16, 4560. 1661-7827 1660-4601 10.3390/ijerph16224560 31752166 https://www.mdpi.com/1660-4601/16/22/4560 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132595277004800 |