Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/9106 |
Resumo: | Members of the I-MOVE-COVID-19 and VEBIS hospital study teams (in addition to the named authors): Svjetlana Karabuva, Petra Tomaš Petrić, Marija Marković, Sandra Ljubičić, Bojana Mahmutović, Irena Tabain, Petra Smoljo, Iva Pem Novosel, Tanya Melillo, John Paul Cauchi, Benédicte Lissoir, Xavier Holemans, Marc Hainaut, Nicolas Dauby, Benedicte Delaere, Marc Bourgeois, Evelyn Petit, Marijke Reynders, Door Jouck, Koen Magerman, Marieke Bleyen, Melissa Vermeulen, Sébastien Fierens, François Dufrasne, Siel Daelemans, Ala’a Al Kerwi, Francoise Berthet, Guy Fagherazzi, Myriam Alexandre, Charlene Bennett, Jim Christle, Jeff Connell, Peter Doran, Laura Feeney, Binita Maharjan, Sinead McDermott, Rosa McNamara, Nadra Nurdin, Salif Mamadou Cissé, Anne-Sophie L'Honneur, Xavier Duval, Yolande Costa, Fidouh Nadhira, Florence Galtier, Laura Crantelle, Vincent Foulongne, Phillipe Vanhems, Sélilah Amour, Bruno Lina, Fabrice Lainé, Laetitia Gallais, Gisèle Lagathu, Anna Maisa, Yacine Saidi, Christine Durier, Rebecca Bauer, Ana Paula Rodrigues, Adriana Silva, Raquel Guiomar, Margarida Tavares, Débora Pereira, Maria José Manata, Heidi Gruner, André Almeida, Paula Pinto, Cristina Bárbara, Itziar Casado, Ana Miqueleiz, Ana Navascués, Camino Trobajo-Sanmartín, Miguel Fernández-Huerta, María Eugenia Portillo, Carmen Ezpeleta, Nerea Egüés, Manuel García Cenoz, Eva Ardanaz, Marcela Guevara, Conchi Moreno-Iribas, Hana Orlíková, Carmen Mihaela Dorobat, Carmen Manciuc, Simin Aysel Florescu, Alexandru Marin, Sorin Dinu, Catalina Pascu, Alina Ivanciuc, Iulia Bistriceanu, Mihaela Oprea, Maria Elena Mihai, Silke Buda, Ute Preuss, Marianne Wedde, Auksė Mickienė, Giedrė Gefenaitė, Alain Moren, Anthony Nardone |
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Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021COVID-19SARS-CoV-2AlphaDeltaVaccine EffectivenessHospitalisationEuropeVacinaEfetividadeIMOVE-COVID19Cuidados de SaúdeMembers of the I-MOVE-COVID-19 and VEBIS hospital study teams (in addition to the named authors): Svjetlana Karabuva, Petra Tomaš Petrić, Marija Marković, Sandra Ljubičić, Bojana Mahmutović, Irena Tabain, Petra Smoljo, Iva Pem Novosel, Tanya Melillo, John Paul Cauchi, Benédicte Lissoir, Xavier Holemans, Marc Hainaut, Nicolas Dauby, Benedicte Delaere, Marc Bourgeois, Evelyn Petit, Marijke Reynders, Door Jouck, Koen Magerman, Marieke Bleyen, Melissa Vermeulen, Sébastien Fierens, François Dufrasne, Siel Daelemans, Ala’a Al Kerwi, Francoise Berthet, Guy Fagherazzi, Myriam Alexandre, Charlene Bennett, Jim Christle, Jeff Connell, Peter Doran, Laura Feeney, Binita Maharjan, Sinead McDermott, Rosa McNamara, Nadra Nurdin, Salif Mamadou Cissé, Anne-Sophie L'Honneur, Xavier Duval, Yolande Costa, Fidouh Nadhira, Florence Galtier, Laura Crantelle, Vincent Foulongne, Phillipe Vanhems, Sélilah Amour, Bruno Lina, Fabrice Lainé, Laetitia Gallais, Gisèle Lagathu, Anna Maisa, Yacine Saidi, Christine Durier, Rebecca Bauer, Ana Paula Rodrigues, Adriana Silva, Raquel Guiomar, Margarida Tavares, Débora Pereira, Maria José Manata, Heidi Gruner, André Almeida, Paula Pinto, Cristina Bárbara, Itziar Casado, Ana Miqueleiz, Ana Navascués, Camino Trobajo-Sanmartín, Miguel Fernández-Huerta, María Eugenia Portillo, Carmen Ezpeleta, Nerea Egüés, Manuel García Cenoz, Eva Ardanaz, Marcela Guevara, Conchi Moreno-Iribas, Hana Orlíková, Carmen Mihaela Dorobat, Carmen Manciuc, Simin Aysel Florescu, Alexandru Marin, Sorin Dinu, Catalina Pascu, Alina Ivanciuc, Iulia Bistriceanu, Mihaela Oprea, Maria Elena Mihai, Silke Buda, Ute Preuss, Marianne Wedde, Auksė Mickienė, Giedrė Gefenaitė, Alain Moren, Anthony NardoneIntroduction: Two large multicentre European hospital networks have estimated vaccine effectiveness (VE) against COVID-19 since 2021. Aim: We aimed to measure VE against PCR-confirmed SARS-CoV-2 in hospitalised severe acute respiratory illness (SARI) patients ≥ 20 years, combining data from these networks during Alpha (March–June)- and Delta (June–December)-dominant periods, 2021. Methods: Forty-six participating hospitals across 14 countries follow a similar generic protocol using the test-negative case–control design. We defined complete primary series vaccination (PSV) as two doses of a two-dose or one of a single-dose vaccine ≥ 14 days before onset. Results: We included 1,087 cases (538 controls) and 1,669 cases (1,442 controls) in the Alpha- and Delta-dominant periods, respectively. During the Alpha period, VE against hospitalisation with SARS-CoV2 for complete Comirnaty PSV was 85% (95% CI: 69–92) overall and 75% (95% CI: 42–90) in those aged ≥ 80 years. During the Delta period, among SARI patients ≥ 20 years with symptom onset ≥ 150 days from last PSV dose, VE for complete Comirnaty PSV was 54% (95% CI: 18–74). Among those receiving Comirnaty PSV and mRNA booster (any product) ≥ 150 days after last PSV dose, VE was 91% (95% CI: 57–98). In time-since-vaccination analysis, complete all-product PSV VE was > 90% in those with their last dose < 90 days before onset; ≥ 70% in those 90–179 days before onset. Conclusions: Our results from this EU multi-country hospital setting showed that VE for complete PSV alone was higher in the Alpha- than the Delta-dominant period, and addition of a first booster dose during the latter period increased VE to over 90%.Key public health message: - What did you want to address in this study? To understand how well the COVID-19 vaccine was performing in Europe against hospitalisation during SARS-CoV-2 Alpha and Delta variant periods, we present vaccine effectiveness results from a multi-country study of complete and booster dose COVID-19 vaccination among adults (aged 20 years and over). - What have we learnt from this study? Between March and June 2021 (Alpha period), vaccine effectiveness against hospitalisation with laboratory-confirmed SARS-CoV-2 was 43% for partial vaccination and 86% for complete vaccination. For June to December 2021 (Delta period), vaccine effectiveness for complete vaccination was lower (52%) but with addition of an mRNA booster dose, effectiveness reached 91%, and remained > 90% up to 119 days after the booster dose. - What are the implications of your findings for public health? In Europe in 2021, COVID-19 vaccine effectiveness results for the Alpha period indicated an excellent benefit for preventing hospitalisation after complete vaccination. During Delta variant circulation, however, a booster dose was required to achieve this level of effectiveness, and this was maintained for up to 4 months post booster.European Centre for Disease Prevention and ControlRepositório Científico do Instituto Nacional de SaúdeRose, Angela M.C.Nicolay, NathalieSandonis Martín, VirginiaMazagatos, ClaraPetrović, GorankaNiessen, F AnnabelMachado, AusendaLaunay, OdileDenayer, SarahSeyler, LucieBaruch, JoaquinBurgui, CristinaLoghin, Isabela I.Domegan, LisaVaikutytė, RobertaHusa, PetrPanagiotakopoulos, GeorgeAouali, NasseraDürrwald, RalfHoward, JenniferPozo, FranciscoSastre-Palou, BartoloméNonković, DianaKnol, Mirjam J.Kislaya, IrinaLuong Nguyen, Liem binhBossuyt, NathalieDemuyser, ThomasDžiugytė, AušraMartínez-Baz, IvánPopescu, CorneliuDuffy, RóisínKuliešė, MonikaSoučková, LenkaMichelaki, StellaSimon, MarcReiche, JanineOtero-Barrós, María TeresaLovrić Makarić, ZvjezdanaBruijning-Verhagen, Patricia C.J.L.Gómez, VerónicaLesieur, ZinebBarbezange, CyrilVan Nedervelde, ElsBorg, Maria-LouiseCastilla, JesúsLazar, MihaelaO’Donnell, JoanJonikaitė, IndrėDemlová, ReginaAmerali, MarinaWirtz, GilTolksdorf, KristinValenciano, MartaBacci, SabrinaKissling, EstherI-MOVE-COVID-19 Hospital Study TeamVEBIS Hospital Study Team2024-02-14T11:25:10Z2023-112023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/9106engEuro Surveill. 2023 Nov;28(47):2300186. doi: 10.2807/1560-7917.ES.2023.28.47.23001861560-791710.2807/1560-7917.ES.2023.28.47.2300186info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-17T01:31:09Zoai:repositorio.insa.pt:10400.18/9106Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:38:33.289735Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 |
| title |
Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 |
| spellingShingle |
Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 Rose, Angela M.C. COVID-19 SARS-CoV-2 Alpha Delta Vaccine Effectiveness Hospitalisation Europe Vacina Efetividade IMOVE-COVID19 Cuidados de Saúde |
| title_short |
Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 |
| title_full |
Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 |
| title_fullStr |
Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 |
| title_full_unstemmed |
Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 |
| title_sort |
Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 |
| author |
Rose, Angela M.C. |
| author_facet |
Rose, Angela M.C. Nicolay, Nathalie Sandonis Martín, Virginia Mazagatos, Clara Petrović, Goranka Niessen, F Annabel Machado, Ausenda Launay, Odile Denayer, Sarah Seyler, Lucie Baruch, Joaquin Burgui, Cristina Loghin, Isabela I. Domegan, Lisa Vaikutytė, Roberta Husa, Petr Panagiotakopoulos, George Aouali, Nassera Dürrwald, Ralf Howard, Jennifer Pozo, Francisco Sastre-Palou, Bartolomé Nonković, Diana Knol, Mirjam J. Kislaya, Irina Luong Nguyen, Liem binh Bossuyt, Nathalie Demuyser, Thomas Džiugytė, Aušra Martínez-Baz, Iván Popescu, Corneliu Duffy, Róisín Kuliešė, Monika Součková, Lenka Michelaki, Stella Simon, Marc Reiche, Janine Otero-Barrós, María Teresa Lovrić Makarić, Zvjezdana Bruijning-Verhagen, Patricia C.J.L. Gómez, Verónica Lesieur, Zineb Barbezange, Cyril Van Nedervelde, Els Borg, Maria-Louise Castilla, Jesús Lazar, Mihaela O’Donnell, Joan Jonikaitė, Indrė Demlová, Regina Amerali, Marina Wirtz, Gil Tolksdorf, Kristin Valenciano, Marta Bacci, Sabrina Kissling, Esther I-MOVE-COVID-19 Hospital Study Team VEBIS Hospital Study Team |
| author_role |
author |
| author2 |
Nicolay, Nathalie Sandonis Martín, Virginia Mazagatos, Clara Petrović, Goranka Niessen, F Annabel Machado, Ausenda Launay, Odile Denayer, Sarah Seyler, Lucie Baruch, Joaquin Burgui, Cristina Loghin, Isabela I. Domegan, Lisa Vaikutytė, Roberta Husa, Petr Panagiotakopoulos, George Aouali, Nassera Dürrwald, Ralf Howard, Jennifer Pozo, Francisco Sastre-Palou, Bartolomé Nonković, Diana Knol, Mirjam J. Kislaya, Irina Luong Nguyen, Liem binh Bossuyt, Nathalie Demuyser, Thomas Džiugytė, Aušra Martínez-Baz, Iván Popescu, Corneliu Duffy, Róisín Kuliešė, Monika Součková, Lenka Michelaki, Stella Simon, Marc Reiche, Janine Otero-Barrós, María Teresa Lovrić Makarić, Zvjezdana Bruijning-Verhagen, Patricia C.J.L. Gómez, Verónica Lesieur, Zineb Barbezange, Cyril Van Nedervelde, Els Borg, Maria-Louise Castilla, Jesús Lazar, Mihaela O’Donnell, Joan Jonikaitė, Indrė Demlová, Regina Amerali, Marina Wirtz, Gil Tolksdorf, Kristin Valenciano, Marta Bacci, Sabrina Kissling, Esther I-MOVE-COVID-19 Hospital Study Team VEBIS Hospital Study Team |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Rose, Angela M.C. Nicolay, Nathalie Sandonis Martín, Virginia Mazagatos, Clara Petrović, Goranka Niessen, F Annabel Machado, Ausenda Launay, Odile Denayer, Sarah Seyler, Lucie Baruch, Joaquin Burgui, Cristina Loghin, Isabela I. Domegan, Lisa Vaikutytė, Roberta Husa, Petr Panagiotakopoulos, George Aouali, Nassera Dürrwald, Ralf Howard, Jennifer Pozo, Francisco Sastre-Palou, Bartolomé Nonković, Diana Knol, Mirjam J. Kislaya, Irina Luong Nguyen, Liem binh Bossuyt, Nathalie Demuyser, Thomas Džiugytė, Aušra Martínez-Baz, Iván Popescu, Corneliu Duffy, Róisín Kuliešė, Monika Součková, Lenka Michelaki, Stella Simon, Marc Reiche, Janine Otero-Barrós, María Teresa Lovrić Makarić, Zvjezdana Bruijning-Verhagen, Patricia C.J.L. Gómez, Verónica Lesieur, Zineb Barbezange, Cyril Van Nedervelde, Els Borg, Maria-Louise Castilla, Jesús Lazar, Mihaela O’Donnell, Joan Jonikaitė, Indrė Demlová, Regina Amerali, Marina Wirtz, Gil Tolksdorf, Kristin Valenciano, Marta Bacci, Sabrina Kissling, Esther I-MOVE-COVID-19 Hospital Study Team VEBIS Hospital Study Team |
| dc.subject.por.fl_str_mv |
COVID-19 SARS-CoV-2 Alpha Delta Vaccine Effectiveness Hospitalisation Europe Vacina Efetividade IMOVE-COVID19 Cuidados de Saúde |
| topic |
COVID-19 SARS-CoV-2 Alpha Delta Vaccine Effectiveness Hospitalisation Europe Vacina Efetividade IMOVE-COVID19 Cuidados de Saúde |
| description |
Members of the I-MOVE-COVID-19 and VEBIS hospital study teams (in addition to the named authors): Svjetlana Karabuva, Petra Tomaš Petrić, Marija Marković, Sandra Ljubičić, Bojana Mahmutović, Irena Tabain, Petra Smoljo, Iva Pem Novosel, Tanya Melillo, John Paul Cauchi, Benédicte Lissoir, Xavier Holemans, Marc Hainaut, Nicolas Dauby, Benedicte Delaere, Marc Bourgeois, Evelyn Petit, Marijke Reynders, Door Jouck, Koen Magerman, Marieke Bleyen, Melissa Vermeulen, Sébastien Fierens, François Dufrasne, Siel Daelemans, Ala’a Al Kerwi, Francoise Berthet, Guy Fagherazzi, Myriam Alexandre, Charlene Bennett, Jim Christle, Jeff Connell, Peter Doran, Laura Feeney, Binita Maharjan, Sinead McDermott, Rosa McNamara, Nadra Nurdin, Salif Mamadou Cissé, Anne-Sophie L'Honneur, Xavier Duval, Yolande Costa, Fidouh Nadhira, Florence Galtier, Laura Crantelle, Vincent Foulongne, Phillipe Vanhems, Sélilah Amour, Bruno Lina, Fabrice Lainé, Laetitia Gallais, Gisèle Lagathu, Anna Maisa, Yacine Saidi, Christine Durier, Rebecca Bauer, Ana Paula Rodrigues, Adriana Silva, Raquel Guiomar, Margarida Tavares, Débora Pereira, Maria José Manata, Heidi Gruner, André Almeida, Paula Pinto, Cristina Bárbara, Itziar Casado, Ana Miqueleiz, Ana Navascués, Camino Trobajo-Sanmartín, Miguel Fernández-Huerta, María Eugenia Portillo, Carmen Ezpeleta, Nerea Egüés, Manuel García Cenoz, Eva Ardanaz, Marcela Guevara, Conchi Moreno-Iribas, Hana Orlíková, Carmen Mihaela Dorobat, Carmen Manciuc, Simin Aysel Florescu, Alexandru Marin, Sorin Dinu, Catalina Pascu, Alina Ivanciuc, Iulia Bistriceanu, Mihaela Oprea, Maria Elena Mihai, Silke Buda, Ute Preuss, Marianne Wedde, Auksė Mickienė, Giedrė Gefenaitė, Alain Moren, Anthony Nardone |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11 2023-11-01T00:00:00Z 2024-02-14T11:25:10Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/9106 |
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http://hdl.handle.net/10400.18/9106 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Euro Surveill. 2023 Nov;28(47):2300186. doi: 10.2807/1560-7917.ES.2023.28.47.2300186 1560-7917 10.2807/1560-7917.ES.2023.28.47.2300186 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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European Centre for Disease Prevention and Control |
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European Centre for Disease Prevention and Control |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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