Engineered living bioassemblies for biomedical and functional material applications

Detalhes bibliográficos
Autor(a) principal: Guimarães, C. F.
Data de Publicação: 2022
Outros Autores: Soto, F., Wang, J., Akin, D., Reis, R. L., Demirci, U.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/79219
Resumo: Recent breakthroughs in biofabrication of bioasemblies, consisting of the engineered structures composed of biological or biosynthetic components into a single construct, have found a wide range of practical applications in medicine and engineering. This review presents an overview of how the bottom-up assembly of living entities could drive advances in medicine, by developing tunable biological models and more precise methods for quantifying biological events. Moreover, we delve into advances beyond biomedical applications, where bioassemblies can be manipulated as functional robots and construction materials. Finally, we address the potential challenges and opportunities in the field of engineering living bioassemblies, toward building new design principles for the next generation of bioengineering applications. 
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spelling Engineered living bioassemblies for biomedical and functional material applicationsassemblybiofabricationBioprintingBiorobotsLab-Grown MeatScience & TechnologyRecent breakthroughs in biofabrication of bioasemblies, consisting of the engineered structures composed of biological or biosynthetic components into a single construct, have found a wide range of practical applications in medicine and engineering. This review presents an overview of how the bottom-up assembly of living entities could drive advances in medicine, by developing tunable biological models and more precise methods for quantifying biological events. Moreover, we delve into advances beyond biomedical applications, where bioassemblies can be manipulated as functional robots and construction materials. Finally, we address the potential challenges and opportunities in the field of engineering living bioassemblies, toward building new design principles for the next generation of bioengineering applications. This work was supported by research funding provided by Stanford RISE COVID-19 Response Faculty Seed Grant and Stanford PHIND Seed Grant programs, Stanford University, United States; F.S. was supported by Schmidt Science Fellows in partnership with the Rhodes Trust. C.F.G acknowledges support from Fundação para a Ciência e Tecnologia, Portugal; (Grant no. PD/BD/135253/2017) and Fundação Luso-Americana para o Desenvolvimento, Portugal(FLAD). The authors thank P.D. Sinawang for helpful discussions and assistance.ElsevierUniversidade do MinhoGuimarães, C. F.Soto, F.Wang, J.Akin, D.Reis, R. L.Demirci, U.2022-082022-08-01T00:00:00Z2024-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/79219engGuimarães C. F., Soto F., Wang J., Akin D., Reis R. L., Demirci U. Engineered living bioassemblies for biomedical and functional material applications, Current Opinion In Biotechnology, Issue 77, pp. 102756, doi:10.1016/j.copbio.2022.102756, 20220958-166910.1016/j.copbio.2022.10275635930844https://www.sciencedirect.com/science/article/pii/S0958166922000908info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:19:55Zoai:repositorium.sdum.uminho.pt:1822/79219Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:12:58.350280Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Engineered living bioassemblies for biomedical and functional material applications
title Engineered living bioassemblies for biomedical and functional material applications
spellingShingle Engineered living bioassemblies for biomedical and functional material applications
Guimarães, C. F.
assembly
biofabrication
Bioprinting
Biorobots
Lab-Grown Meat
Science & Technology
title_short Engineered living bioassemblies for biomedical and functional material applications
title_full Engineered living bioassemblies for biomedical and functional material applications
title_fullStr Engineered living bioassemblies for biomedical and functional material applications
title_full_unstemmed Engineered living bioassemblies for biomedical and functional material applications
title_sort Engineered living bioassemblies for biomedical and functional material applications
author Guimarães, C. F.
author_facet Guimarães, C. F.
Soto, F.
Wang, J.
Akin, D.
Reis, R. L.
Demirci, U.
author_role author
author2 Soto, F.
Wang, J.
Akin, D.
Reis, R. L.
Demirci, U.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Guimarães, C. F.
Soto, F.
Wang, J.
Akin, D.
Reis, R. L.
Demirci, U.
dc.subject.por.fl_str_mv assembly
biofabrication
Bioprinting
Biorobots
Lab-Grown Meat
Science & Technology
topic assembly
biofabrication
Bioprinting
Biorobots
Lab-Grown Meat
Science & Technology
description Recent breakthroughs in biofabrication of bioasemblies, consisting of the engineered structures composed of biological or biosynthetic components into a single construct, have found a wide range of practical applications in medicine and engineering. This review presents an overview of how the bottom-up assembly of living entities could drive advances in medicine, by developing tunable biological models and more precise methods for quantifying biological events. Moreover, we delve into advances beyond biomedical applications, where bioassemblies can be manipulated as functional robots and construction materials. Finally, we address the potential challenges and opportunities in the field of engineering living bioassemblies, toward building new design principles for the next generation of bioengineering applications. 
publishDate 2022
dc.date.none.fl_str_mv 2022-08
2022-08-01T00:00:00Z
2024-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/79219
url https://hdl.handle.net/1822/79219
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Guimarães C. F., Soto F., Wang J., Akin D., Reis R. L., Demirci U. Engineered living bioassemblies for biomedical and functional material applications, Current Opinion In Biotechnology, Issue 77, pp. 102756, doi:10.1016/j.copbio.2022.102756, 2022
0958-1669
10.1016/j.copbio.2022.102756
35930844
https://www.sciencedirect.com/science/article/pii/S0958166922000908
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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