Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/31433 https://doi.org/10.1002/tcr.202000167 |
Resumo: | Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained. |
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Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversityisatinspirooxindolesmulticomponent reactionssustainabilitycatalysisoxindoleMulticomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained.The Chemical Society of Japan & Wiley-VCH GmbH2022-03-23T16:16:40Z2022-03-232021-02-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/31433http://hdl.handle.net/10174/31433https://doi.org/10.1002/tcr.202000167enghttps://onlinelibrary.wiley.com/doi/10.1002/tcr.202000167ndcarolsmarq@uevora.ptbetepc@uevora.ptndajb@uevora.pt307Brandão, PedroMarques, Carolina S.Carreiro, Elisabete P.Pineiro, MartaBurke, Anthony J.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:31:13Zoai:dspace.uevora.pt:10174/31433Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:20:39.531789Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity |
title |
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity |
spellingShingle |
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity Brandão, Pedro isatin spirooxindoles multicomponent reactions sustainability catalysis oxindole |
title_short |
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity |
title_full |
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity |
title_fullStr |
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity |
title_full_unstemmed |
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity |
title_sort |
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity |
author |
Brandão, Pedro |
author_facet |
Brandão, Pedro Marques, Carolina S. Carreiro, Elisabete P. Pineiro, Marta Burke, Anthony J. |
author_role |
author |
author2 |
Marques, Carolina S. Carreiro, Elisabete P. Pineiro, Marta Burke, Anthony J. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Brandão, Pedro Marques, Carolina S. Carreiro, Elisabete P. Pineiro, Marta Burke, Anthony J. |
dc.subject.por.fl_str_mv |
isatin spirooxindoles multicomponent reactions sustainability catalysis oxindole |
topic |
isatin spirooxindoles multicomponent reactions sustainability catalysis oxindole |
description |
Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-02-14T00:00:00Z 2022-03-23T16:16:40Z 2022-03-23 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/31433 http://hdl.handle.net/10174/31433 https://doi.org/10.1002/tcr.202000167 |
url |
http://hdl.handle.net/10174/31433 https://doi.org/10.1002/tcr.202000167 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://onlinelibrary.wiley.com/doi/10.1002/tcr.202000167 nd carolsmarq@uevora.pt betepc@uevora.pt nd ajb@uevora.pt 307 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
The Chemical Society of Japan & Wiley-VCH GmbH |
publisher.none.fl_str_mv |
The Chemical Society of Japan & Wiley-VCH GmbH |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136688075702272 |