Maternal risk factors for the VACTERL association: a EUROCAT case-control study
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/7350 |
Resumo: | The data that support the findings of this study are available from the EUROCAT registries. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Maternal risk factors for the VACTERL association: a EUROCAT case-control studyAssisted Reproductive TechniquesEtiologyMaternal FactorsPregestational DiabetesRespiratory DisordersAnomalias CongénitasEstados de Saúde e de DoençaObservação em Saúde e VigilânciaRegisto Nacional de Anomalias CongénitasRENACEuropean Surveillance of Congenital AnomaliesEUROCATRegistos EpidemiológicosEuropePortugalThe data that support the findings of this study are available from the EUROCAT registries.Background: The VACTERL association (VACTERL) is the nonrandom occurrence of at least three of these congenital anomalies: vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies. Despite suggestions for involvement of several genes and nongenetic risk factors from small studies, the etiology of VACTERL remains largely unknown. Objective: To identify maternal risk factors for VACTERL in offspring in a large European study. Methods: A case-control study was performed using data from 28 EUROCAT registries over the period 1997-2015 with case and control ascertainment through hospital records, birth and death certificates, questionnaires, and/or postmortem examinations. Cases were diagnosed with VACTERL, while controls had a genetic syndrome and/or chromosomal abnormality. Data collected included type of birth defect and maternal characteristics, such as age, use of assisted reproductive techniques (ART), and chronic illnesses. Multivariable logistic regression analyses were performed to estimate confounder adjusted odds ratios (aOR) with 95% confidence intervals (95% CI). Results: The study population consisted of 329 VACTERL cases and 49,724 controls with recognized syndromes or chromosomal abnormality. For couples who conceived through ART, we found an increased risk of VACTERL (aOR 2.3 [95% CI 1.3, 3.9]) in offspring. Pregestational diabetes (aOR 3.1 [95% CI 1.1, 8.6]) and chronic lower obstructive pulmonary diseases (aOR 3.9 [95% CI 2.2, 6.7]) also increased the risk of having a child with VACTERL. Twin pregnancies were not associated with VACTERL (aOR 0.6 [95% CI 0.3, 1.4]). Conclusion: We identified several maternal risk factors for VACTERL in offspring befitting a multifactorial etiology.WileyRepositório Científico do Instituto Nacional de Saúdevan de Putte, Romyvan Rooij, Iris A.L.M.Haanappel, Cynthia P.Marcelis, Carlo L.M.Brunner, Han G.Addor, Marie‐ClaudeCavero‐Carbonell, ClaraMatias Dias, CarlosDraper, Elizabeth S.Etxebarriarteun, LarraitzGatt, MiriamKhoshnood, BabakKinsner‐Ovaskainen, AgnieszkaKlungsoyr, KariKurinczuk, Jenny J.Latos‐Bielenska, AnnaLuyt, KarenO'Mahony, Mary T.Miller, NicolaMullaney, CarmelNelen, VeraNeville, Amanda J.Perthus, IsabellePierini, AnnaRandrianaivo, HanitraRankin, JudithRissmann, AnkeRouget, FlorenceSchaub, BrunoTucker, DavidWellesley, DianaWiesel, AwiZymak‐Zakutnia, NatalyaLoane, MariaBarisic, IngeborgWalle, Hermien E.K.Bergman, Jorieke E.H.Roeleveld, Nel2021-03-06T16:26:41Z2020-05-152020-05-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7350engBirth Defects Res. 2020 May 15;112(9):688-698. doi: 10.1002/bdr2.1686. Epub 2020 Apr 22.2472-172710.1002/bdr2.1686info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:54Zoai:repositorio.insa.pt:10400.18/7350Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:56.299366Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Maternal risk factors for the VACTERL association: a EUROCAT case-control study |
| title |
Maternal risk factors for the VACTERL association: a EUROCAT case-control study |
| spellingShingle |
Maternal risk factors for the VACTERL association: a EUROCAT case-control study van de Putte, Romy Assisted Reproductive Techniques Etiology Maternal Factors Pregestational Diabetes Respiratory Disorders Anomalias Congénitas Estados de Saúde e de Doença Observação em Saúde e Vigilância Registo Nacional de Anomalias Congénitas RENAC European Surveillance of Congenital Anomalies EUROCAT Registos Epidemiológicos Europe Portugal |
| title_short |
Maternal risk factors for the VACTERL association: a EUROCAT case-control study |
| title_full |
Maternal risk factors for the VACTERL association: a EUROCAT case-control study |
| title_fullStr |
Maternal risk factors for the VACTERL association: a EUROCAT case-control study |
| title_full_unstemmed |
Maternal risk factors for the VACTERL association: a EUROCAT case-control study |
| title_sort |
Maternal risk factors for the VACTERL association: a EUROCAT case-control study |
| author |
van de Putte, Romy |
| author_facet |
van de Putte, Romy van Rooij, Iris A.L.M. Haanappel, Cynthia P. Marcelis, Carlo L.M. Brunner, Han G. Addor, Marie‐Claude Cavero‐Carbonell, Clara Matias Dias, Carlos Draper, Elizabeth S. Etxebarriarteun, Larraitz Gatt, Miriam Khoshnood, Babak Kinsner‐Ovaskainen, Agnieszka Klungsoyr, Kari Kurinczuk, Jenny J. Latos‐Bielenska, Anna Luyt, Karen O'Mahony, Mary T. Miller, Nicola Mullaney, Carmel Nelen, Vera Neville, Amanda J. Perthus, Isabelle Pierini, Anna Randrianaivo, Hanitra Rankin, Judith Rissmann, Anke Rouget, Florence Schaub, Bruno Tucker, David Wellesley, Diana Wiesel, Awi Zymak‐Zakutnia, Natalya Loane, Maria Barisic, Ingeborg Walle, Hermien E.K. Bergman, Jorieke E.H. Roeleveld, Nel |
| author_role |
author |
| author2 |
van Rooij, Iris A.L.M. Haanappel, Cynthia P. Marcelis, Carlo L.M. Brunner, Han G. Addor, Marie‐Claude Cavero‐Carbonell, Clara Matias Dias, Carlos Draper, Elizabeth S. Etxebarriarteun, Larraitz Gatt, Miriam Khoshnood, Babak Kinsner‐Ovaskainen, Agnieszka Klungsoyr, Kari Kurinczuk, Jenny J. Latos‐Bielenska, Anna Luyt, Karen O'Mahony, Mary T. Miller, Nicola Mullaney, Carmel Nelen, Vera Neville, Amanda J. Perthus, Isabelle Pierini, Anna Randrianaivo, Hanitra Rankin, Judith Rissmann, Anke Rouget, Florence Schaub, Bruno Tucker, David Wellesley, Diana Wiesel, Awi Zymak‐Zakutnia, Natalya Loane, Maria Barisic, Ingeborg Walle, Hermien E.K. Bergman, Jorieke E.H. Roeleveld, Nel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
van de Putte, Romy van Rooij, Iris A.L.M. Haanappel, Cynthia P. Marcelis, Carlo L.M. Brunner, Han G. Addor, Marie‐Claude Cavero‐Carbonell, Clara Matias Dias, Carlos Draper, Elizabeth S. Etxebarriarteun, Larraitz Gatt, Miriam Khoshnood, Babak Kinsner‐Ovaskainen, Agnieszka Klungsoyr, Kari Kurinczuk, Jenny J. Latos‐Bielenska, Anna Luyt, Karen O'Mahony, Mary T. Miller, Nicola Mullaney, Carmel Nelen, Vera Neville, Amanda J. Perthus, Isabelle Pierini, Anna Randrianaivo, Hanitra Rankin, Judith Rissmann, Anke Rouget, Florence Schaub, Bruno Tucker, David Wellesley, Diana Wiesel, Awi Zymak‐Zakutnia, Natalya Loane, Maria Barisic, Ingeborg Walle, Hermien E.K. Bergman, Jorieke E.H. Roeleveld, Nel |
| dc.subject.por.fl_str_mv |
Assisted Reproductive Techniques Etiology Maternal Factors Pregestational Diabetes Respiratory Disorders Anomalias Congénitas Estados de Saúde e de Doença Observação em Saúde e Vigilância Registo Nacional de Anomalias Congénitas RENAC European Surveillance of Congenital Anomalies EUROCAT Registos Epidemiológicos Europe Portugal |
| topic |
Assisted Reproductive Techniques Etiology Maternal Factors Pregestational Diabetes Respiratory Disorders Anomalias Congénitas Estados de Saúde e de Doença Observação em Saúde e Vigilância Registo Nacional de Anomalias Congénitas RENAC European Surveillance of Congenital Anomalies EUROCAT Registos Epidemiológicos Europe Portugal |
| description |
The data that support the findings of this study are available from the EUROCAT registries. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-05-15 2020-05-15T00:00:00Z 2021-03-06T16:26:41Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/7350 |
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http://hdl.handle.net/10400.18/7350 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Birth Defects Res. 2020 May 15;112(9):688-698. doi: 10.1002/bdr2.1686. Epub 2020 Apr 22. 2472-1727 10.1002/bdr2.1686 |
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embargoedAccess |
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application/pdf |
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Wiley |
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Wiley |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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