Combined therapy in non-insulin-dependent diabetes mellitus.
Autor(a) principal: | |
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Data de Publicação: | 1993 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3087 |
Resumo: | In recent years an improved understanding of potential complications associated with hyperinsulinemia has led to a growing interest in alternatives to insulin monotherapy for patients with non-insulin-dependent diabetes mellitus, who have failed on a regimen of diet and sulphonylureas. These patients typically present normal or elevated levels of insulin. This problem which has been attributed to insulin resistance, is superimposed on the peripheral hyperinsulinemia resulting from subcutaneous insulin delivery. A plethora of clinical trials have reported on the efficacy of combining therapy in limiting insulin requirements while achieving better glycemic control. This paper attempts a critical review of the pros and cons with respect to combining therapy and provides guidelines for its practical use. |
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Combined therapy in non-insulin-dependent diabetes mellitus.Terapêutica combinada na diabetes mellitus não insulino-dependente.In recent years an improved understanding of potential complications associated with hyperinsulinemia has led to a growing interest in alternatives to insulin monotherapy for patients with non-insulin-dependent diabetes mellitus, who have failed on a regimen of diet and sulphonylureas. These patients typically present normal or elevated levels of insulin. This problem which has been attributed to insulin resistance, is superimposed on the peripheral hyperinsulinemia resulting from subcutaneous insulin delivery. A plethora of clinical trials have reported on the efficacy of combining therapy in limiting insulin requirements while achieving better glycemic control. This paper attempts a critical review of the pros and cons with respect to combining therapy and provides guidelines for its practical use.In recent years an improved understanding of potential complications associated with hyperinsulinemia has led to a growing interest in alternatives to insulin monotherapy for patients with non-insulin-dependent diabetes mellitus, who have failed on a regimen of diet and sulphonylureas. These patients typically present normal or elevated levels of insulin. This problem which has been attributed to insulin resistance, is superimposed on the peripheral hyperinsulinemia resulting from subcutaneous insulin delivery. A plethora of clinical trials have reported on the efficacy of combining therapy in limiting insulin requirements while achieving better glycemic control. This paper attempts a critical review of the pros and cons with respect to combining therapy and provides guidelines for its practical use.Ordem dos Médicos1993-06-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3087oai:ojs.www.actamedicaportuguesa.com:article/3087Acta Médica Portuguesa; Vol. 6 No. 6 (1993): Junho; 287-90Acta Médica Portuguesa; Vol. 6 N.º 6 (1993): Junho; 287-901646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3087https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3087/2429Ferreira, FSobrinho, L Ginfo:eu-repo/semantics/openAccess2022-12-20T11:01:37ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Combined therapy in non-insulin-dependent diabetes mellitus. Terapêutica combinada na diabetes mellitus não insulino-dependente. |
title |
Combined therapy in non-insulin-dependent diabetes mellitus. |
spellingShingle |
Combined therapy in non-insulin-dependent diabetes mellitus. Ferreira, F |
title_short |
Combined therapy in non-insulin-dependent diabetes mellitus. |
title_full |
Combined therapy in non-insulin-dependent diabetes mellitus. |
title_fullStr |
Combined therapy in non-insulin-dependent diabetes mellitus. |
title_full_unstemmed |
Combined therapy in non-insulin-dependent diabetes mellitus. |
title_sort |
Combined therapy in non-insulin-dependent diabetes mellitus. |
author |
Ferreira, F |
author_facet |
Ferreira, F Sobrinho, L G |
author_role |
author |
author2 |
Sobrinho, L G |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Ferreira, F Sobrinho, L G |
description |
In recent years an improved understanding of potential complications associated with hyperinsulinemia has led to a growing interest in alternatives to insulin monotherapy for patients with non-insulin-dependent diabetes mellitus, who have failed on a regimen of diet and sulphonylureas. These patients typically present normal or elevated levels of insulin. This problem which has been attributed to insulin resistance, is superimposed on the peripheral hyperinsulinemia resulting from subcutaneous insulin delivery. A plethora of clinical trials have reported on the efficacy of combining therapy in limiting insulin requirements while achieving better glycemic control. This paper attempts a critical review of the pros and cons with respect to combining therapy and provides guidelines for its practical use. |
publishDate |
1993 |
dc.date.none.fl_str_mv |
1993-06-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3087 oai:ojs.www.actamedicaportuguesa.com:article/3087 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3087 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/3087 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3087 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3087/2429 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 6 No. 6 (1993): Junho; 287-90 Acta Médica Portuguesa; Vol. 6 N.º 6 (1993): Junho; 287-90 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777301639383744512 |