Changes in bone Pb accumulation: Cause and effect of altered bone turnover
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.26/8157 |
Resumo: | Notice: this is the author’s version of a work that was accepted for publication in Bone. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bone, [Vol 64 (2014 Jul)] DOI 10.1016/j.bone.2014.04.021 |
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Changes in bone Pb accumulation: Cause and effect of altered bone turnoverPb exposureBone turnoverOsteoporosisKinetic modelsNotice: this is the author’s version of a work that was accepted for publication in Bone. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bone, [Vol 64 (2014 Jul)] DOI 10.1016/j.bone.2014.04.021"This paper assesses the magnitude of Pb uptake in cortical and trabecular bones in healthy animals and animals with altered balance in bone turnover, and the impact of exposure to Pb on serum markers of bone formation and resorption. The results reported herein provide physiological evidence that Pb distributes differently in central compartments in Pb metabolism, such as cortical and trabecular bone, in healthy animals and animals with altered balance in bone turnover, and that exposure to Pb does have an impact on bone resorption resulting in OC-dependent osteopenia. These findings show that Pb may play a role in the etiology of osteoporosis and that its concentration in bones varies as a result of altered bone turnover characteristic of this disease, a long standing question in the field. In addition, data collected in this study are consistent with previous observations of increased half-life of Pb in bone at higher exposures. This evidence is relevant for the necessary revision of current physiologically based kinetic models for Pb in humans."ElsevierRepositório ComumBrito, José A.Costa, Isabel M.Silva, Alexandra M. eMarques, José M.Zagalo, Carlos M.Cavaleiro, Inês I.Fernandes, Tânia A.Gonçalves, Luísa L.2015-03-27T16:21:07Z2014-07-01T00:00:00Z2014-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/8157engBone. 2014 Jul;64:228-34. doi: 10.1016/j.bone.2014.04.021.8756-3282info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:51:32Zoai:comum.rcaap.pt:10400.26/8157Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:06:14.193714Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Changes in bone Pb accumulation: Cause and effect of altered bone turnover |
| title |
Changes in bone Pb accumulation: Cause and effect of altered bone turnover |
| spellingShingle |
Changes in bone Pb accumulation: Cause and effect of altered bone turnover Brito, José A. Pb exposure Bone turnover Osteoporosis Kinetic models |
| title_short |
Changes in bone Pb accumulation: Cause and effect of altered bone turnover |
| title_full |
Changes in bone Pb accumulation: Cause and effect of altered bone turnover |
| title_fullStr |
Changes in bone Pb accumulation: Cause and effect of altered bone turnover |
| title_full_unstemmed |
Changes in bone Pb accumulation: Cause and effect of altered bone turnover |
| title_sort |
Changes in bone Pb accumulation: Cause and effect of altered bone turnover |
| author |
Brito, José A. |
| author_facet |
Brito, José A. Costa, Isabel M. Silva, Alexandra M. e Marques, José M. Zagalo, Carlos M. Cavaleiro, Inês I. Fernandes, Tânia A. Gonçalves, Luísa L. |
| author_role |
author |
| author2 |
Costa, Isabel M. Silva, Alexandra M. e Marques, José M. Zagalo, Carlos M. Cavaleiro, Inês I. Fernandes, Tânia A. Gonçalves, Luísa L. |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Comum |
| dc.contributor.author.fl_str_mv |
Brito, José A. Costa, Isabel M. Silva, Alexandra M. e Marques, José M. Zagalo, Carlos M. Cavaleiro, Inês I. Fernandes, Tânia A. Gonçalves, Luísa L. |
| dc.subject.por.fl_str_mv |
Pb exposure Bone turnover Osteoporosis Kinetic models |
| topic |
Pb exposure Bone turnover Osteoporosis Kinetic models |
| description |
Notice: this is the author’s version of a work that was accepted for publication in Bone. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bone, [Vol 64 (2014 Jul)] DOI 10.1016/j.bone.2014.04.021 |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-07-01T00:00:00Z 2014-07-01T00:00:00Z 2015-03-27T16:21:07Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/8157 |
| url |
http://hdl.handle.net/10400.26/8157 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Bone. 2014 Jul;64:228-34. doi: 10.1016/j.bone.2014.04.021. 8756-3282 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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