Synthesis and characterization of self-assembled nanogels made of pullulan
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/16782 |
Resumo: | Self-assembled nanogels made of hydrophobized pullulan were obtained using a versatile, simple, reproducible and low-cost method. In a first reaction pullulan was modified with hydroxyethyl methacrylate or vinyl methacrylate, further modified in the second step with hydrophobic 1-hexadecanethiol, resulting as an amphiphilic material, which self-assembles in water via the hydrophobic interaction among alkyl chains. Structural features, size, shape, surface charge and stability of the nanogels were studied using hydrogen nuclear magnetic resonance, fluorescence spectroscopy, cryo-field emission scanning electron microscopy and dynamic light scattering. Above the critical aggregation concentration spherical polydisperse macromolecular micelles revealed long-term colloidal stability in aqueous medium, with a nearly neutral negative surface charge and mean hydrodynamic diameter in the range 100-400 nm, depending on the polymer degree of substitution. Good size stability was observed when nanogels were exposed to potential destabilizing conditions of pH. While the size stability of the nanogel made of pullulan with vinyl methacrylate and more hydrophobic chains grafted was affected by the ionic strength and urea, nanogel made of pullulan with hydroxyethyl methacrylate and fewer hydrophobic chains grafted remained stable. |
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Synthesis and characterization of self-assembled nanogels made of pullulanPullulanSynthetic nanogelsSelf-assemblyAmphiphilic macromolecular micellesMichael additionHydrophobic domainsScience & TechnologySelf-assembled nanogels made of hydrophobized pullulan were obtained using a versatile, simple, reproducible and low-cost method. In a first reaction pullulan was modified with hydroxyethyl methacrylate or vinyl methacrylate, further modified in the second step with hydrophobic 1-hexadecanethiol, resulting as an amphiphilic material, which self-assembles in water via the hydrophobic interaction among alkyl chains. Structural features, size, shape, surface charge and stability of the nanogels were studied using hydrogen nuclear magnetic resonance, fluorescence spectroscopy, cryo-field emission scanning electron microscopy and dynamic light scattering. Above the critical aggregation concentration spherical polydisperse macromolecular micelles revealed long-term colloidal stability in aqueous medium, with a nearly neutral negative surface charge and mean hydrodynamic diameter in the range 100-400 nm, depending on the polymer degree of substitution. Good size stability was observed when nanogels were exposed to potential destabilizing conditions of pH. While the size stability of the nanogel made of pullulan with vinyl methacrylate and more hydrophobic chains grafted was affected by the ionic strength and urea, nanogel made of pullulan with hydroxyethyl methacrylate and fewer hydrophobic chains grafted remained stable.We thank for the financial support by International Iberian Nanotechnology Laboratory (INL) and FCT through POCTI.MDPI PublishingUniversidade do MinhoFerreira, Sílvia A.Coutinho, Paulo J. G.Gama, F. M.2011-032011-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/16782eng1996-194410.3390/ma4040601info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:07:30Zoai:repositorium.sdum.uminho.pt:1822/16782Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:58:29.943593Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Synthesis and characterization of self-assembled nanogels made of pullulan |
title |
Synthesis and characterization of self-assembled nanogels made of pullulan |
spellingShingle |
Synthesis and characterization of self-assembled nanogels made of pullulan Ferreira, Sílvia A. Pullulan Synthetic nanogels Self-assembly Amphiphilic macromolecular micelles Michael addition Hydrophobic domains Science & Technology |
title_short |
Synthesis and characterization of self-assembled nanogels made of pullulan |
title_full |
Synthesis and characterization of self-assembled nanogels made of pullulan |
title_fullStr |
Synthesis and characterization of self-assembled nanogels made of pullulan |
title_full_unstemmed |
Synthesis and characterization of self-assembled nanogels made of pullulan |
title_sort |
Synthesis and characterization of self-assembled nanogels made of pullulan |
author |
Ferreira, Sílvia A. |
author_facet |
Ferreira, Sílvia A. Coutinho, Paulo J. G. Gama, F. M. |
author_role |
author |
author2 |
Coutinho, Paulo J. G. Gama, F. M. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ferreira, Sílvia A. Coutinho, Paulo J. G. Gama, F. M. |
dc.subject.por.fl_str_mv |
Pullulan Synthetic nanogels Self-assembly Amphiphilic macromolecular micelles Michael addition Hydrophobic domains Science & Technology |
topic |
Pullulan Synthetic nanogels Self-assembly Amphiphilic macromolecular micelles Michael addition Hydrophobic domains Science & Technology |
description |
Self-assembled nanogels made of hydrophobized pullulan were obtained using a versatile, simple, reproducible and low-cost method. In a first reaction pullulan was modified with hydroxyethyl methacrylate or vinyl methacrylate, further modified in the second step with hydrophobic 1-hexadecanethiol, resulting as an amphiphilic material, which self-assembles in water via the hydrophobic interaction among alkyl chains. Structural features, size, shape, surface charge and stability of the nanogels were studied using hydrogen nuclear magnetic resonance, fluorescence spectroscopy, cryo-field emission scanning electron microscopy and dynamic light scattering. Above the critical aggregation concentration spherical polydisperse macromolecular micelles revealed long-term colloidal stability in aqueous medium, with a nearly neutral negative surface charge and mean hydrodynamic diameter in the range 100-400 nm, depending on the polymer degree of substitution. Good size stability was observed when nanogels were exposed to potential destabilizing conditions of pH. While the size stability of the nanogel made of pullulan with vinyl methacrylate and more hydrophobic chains grafted was affected by the ionic strength and urea, nanogel made of pullulan with hydroxyethyl methacrylate and fewer hydrophobic chains grafted remained stable. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-03 2011-03-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/16782 |
url |
http://hdl.handle.net/1822/16782 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1996-1944 10.3390/ma4040601 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI Publishing |
publisher.none.fl_str_mv |
MDPI Publishing |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132374775103488 |