Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/33566 https://doi.org/Venâncio C, Monteiro B, Francisco R, Neves MC, Freire MG, Sousa ACA, Lopes I (2022) "Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization." Medical Sciences Forum 14(1): 101. https://doi.org/10.3390/ECMC2022-13246 https://doi.org/10.3390/ECMC2022-13246 |
Resumo: | Given the growing number of cancer diseases, new cytostatic drugs are approved daily, often with concomitant development, or refinement of some of these drugs aimed at decreasing patient discomfort during the administration period (e.g., prodrugs). Classified as highly toxic, they represent a major environmental problem that may potentiate disease occurrences. For newer cytostatic and prodrugs there are no (or few) reported effects to aquatic organisms; therefore, their prioritization is constrained. In light of the points raised, the IonCytDevice project intended to bridge some of these knowledge gaps and has delivered important benchmarks. Predictions have been obtained on the environmental impacts of three cytostatics (cyclophosphamide: CYP; 5-fluoroucil: 5-FU; and mycophenolic acid: MPA) and one prodrug (capecitabine: CAP) on freshwater biota, with a focus on new species and endpoints likely to be also framed in meta-analysis studies. The results reveal that, for now, CYP, 5-FU, and CAP (prodrug) pose no risk, whilst MPA was flagged as a high environmental risk. |
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Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug PrioritizationantineoplasticsalgaecancerzebrafishhydraGiven the growing number of cancer diseases, new cytostatic drugs are approved daily, often with concomitant development, or refinement of some of these drugs aimed at decreasing patient discomfort during the administration period (e.g., prodrugs). Classified as highly toxic, they represent a major environmental problem that may potentiate disease occurrences. For newer cytostatic and prodrugs there are no (or few) reported effects to aquatic organisms; therefore, their prioritization is constrained. In light of the points raised, the IonCytDevice project intended to bridge some of these knowledge gaps and has delivered important benchmarks. Predictions have been obtained on the environmental impacts of three cytostatics (cyclophosphamide: CYP; 5-fluoroucil: 5-FU; and mycophenolic acid: MPA) and one prodrug (capecitabine: CAP) on freshwater biota, with a focus on new species and endpoints likely to be also framed in meta-analysis studies. The results reveal that, for now, CYP, 5-FU, and CAP (prodrug) pose no risk, whilst MPA was flagged as a high environmental risk.Medical Sciences Forum (MDPI)2023-01-23T14:37:01Z2023-01-232022-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/33566https://doi.org/Venâncio C, Monteiro B, Francisco R, Neves MC, Freire MG, Sousa ACA, Lopes I (2022) "Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization." Medical Sciences Forum 14(1): 101. https://doi.org/10.3390/ECMC2022-13246http://hdl.handle.net/10174/33566https://doi.org/10.3390/ECMC2022-13246porhttps://www.mdpi.com/2673-9992/14/1/101CHRCcatiavenancio@gmail.comndndmcneves@ua.ptmgfreire@ua.ptacsousa@uevora.ptilopes@ua.pt592Venâncio, CátiaMonteiro, BrunaFrancisco, RafaelNeves, Márcia CFreire, Mara GSousa, Ana C ALopes, Isabelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-08T04:49:10ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization |
title |
Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization |
spellingShingle |
Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization Venâncio, Cátia antineoplastics algae cancer zebrafish hydra |
title_short |
Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization |
title_full |
Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization |
title_fullStr |
Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization |
title_full_unstemmed |
Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization |
title_sort |
Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization |
author |
Venâncio, Cátia |
author_facet |
Venâncio, Cátia Monteiro, Bruna Francisco, Rafael Neves, Márcia C Freire, Mara G Sousa, Ana C A Lopes, Isabel |
author_role |
author |
author2 |
Monteiro, Bruna Francisco, Rafael Neves, Márcia C Freire, Mara G Sousa, Ana C A Lopes, Isabel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Venâncio, Cátia Monteiro, Bruna Francisco, Rafael Neves, Márcia C Freire, Mara G Sousa, Ana C A Lopes, Isabel |
dc.subject.por.fl_str_mv |
antineoplastics algae cancer zebrafish hydra |
topic |
antineoplastics algae cancer zebrafish hydra |
description |
Given the growing number of cancer diseases, new cytostatic drugs are approved daily, often with concomitant development, or refinement of some of these drugs aimed at decreasing patient discomfort during the administration period (e.g., prodrugs). Classified as highly toxic, they represent a major environmental problem that may potentiate disease occurrences. For newer cytostatic and prodrugs there are no (or few) reported effects to aquatic organisms; therefore, their prioritization is constrained. In light of the points raised, the IonCytDevice project intended to bridge some of these knowledge gaps and has delivered important benchmarks. Predictions have been obtained on the environmental impacts of three cytostatics (cyclophosphamide: CYP; 5-fluoroucil: 5-FU; and mycophenolic acid: MPA) and one prodrug (capecitabine: CAP) on freshwater biota, with a focus on new species and endpoints likely to be also framed in meta-analysis studies. The results reveal that, for now, CYP, 5-FU, and CAP (prodrug) pose no risk, whilst MPA was flagged as a high environmental risk. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-01T00:00:00Z 2023-01-23T14:37:01Z 2023-01-23 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/33566 https://doi.org/Venâncio C, Monteiro B, Francisco R, Neves MC, Freire MG, Sousa ACA, Lopes I (2022) "Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization." Medical Sciences Forum 14(1): 101. https://doi.org/10.3390/ECMC2022-13246 http://hdl.handle.net/10174/33566 https://doi.org/10.3390/ECMC2022-13246 |
url |
http://hdl.handle.net/10174/33566 https://doi.org/Venâncio C, Monteiro B, Francisco R, Neves MC, Freire MG, Sousa ACA, Lopes I (2022) "Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization." Medical Sciences Forum 14(1): 101. https://doi.org/10.3390/ECMC2022-13246 https://doi.org/10.3390/ECMC2022-13246 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.mdpi.com/2673-9992/14/1/101 CHRC catiavenancio@gmail.com nd nd mcneves@ua.pt mgfreire@ua.pt acsousa@uevora.pt ilopes@ua.pt 592 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Medical Sciences Forum (MDPI) |
publisher.none.fl_str_mv |
Medical Sciences Forum (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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