Pediatric Nephrotoxicity: How Aware Are We?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057 |
Resumo: | ABSTRACT Vancomycin and aminoglycosides are potentially nephrotoxic broad-spectrum antibiotics, which can be used both in the treatment of severe infections and in surgical prophylaxis, in pediatric patients. Prolonged antibiotic therapy and high trough concentrations are associated with toxicity. Additionally, several individual factors contribute to nephrotoxicity increasing the risk of acute kidney injury (AKI) and consequente chronic kidney disease in the future. We developed a retrospective and observational study in the Pediatrics Department of a tertiary hospital in Portugal, to analyze clinical practice regarding monitoring and surveillance of vancomycin and aminoglycosides. The results showed low rates of monitoring, which reinforces the importance of raising awareness about this issue, recognizing its importance, and adopting preventive measures that may mitigate the risk of toxicity and improve children’s renal prognosis in adult life. |
id |
RCAP_f6f4c1ba3287a1aa8ba2182ae6e16f63 |
---|---|
oai_identifier_str |
oai:scielo:S0872-01692023000200057 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Pediatric Nephrotoxicity: How Aware Are We?Acute Kidney Injury/complicationsAminoglycosides/adverse effectsChildKidney/drug effectsKidney Diseases/chemically inducedRenal Insufficiency, Chronic/chemically inducedVancomycin/adverse effectsABSTRACT Vancomycin and aminoglycosides are potentially nephrotoxic broad-spectrum antibiotics, which can be used both in the treatment of severe infections and in surgical prophylaxis, in pediatric patients. Prolonged antibiotic therapy and high trough concentrations are associated with toxicity. Additionally, several individual factors contribute to nephrotoxicity increasing the risk of acute kidney injury (AKI) and consequente chronic kidney disease in the future. We developed a retrospective and observational study in the Pediatrics Department of a tertiary hospital in Portugal, to analyze clinical practice regarding monitoring and surveillance of vancomycin and aminoglycosides. The results showed low rates of monitoring, which reinforces the importance of raising awareness about this issue, recognizing its importance, and adopting preventive measures that may mitigate the risk of toxicity and improve children’s renal prognosis in adult life.Sociedade Portuguesa de Nefrologia2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057Portuguese Journal of Nephrology & Hypertension v.37 n.2 2023reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057Figueiredo,Cátia RaquelDurão,FilipaZagalo,AnaSandes,Ana RitaSilva,José EduardoStone,Rosárioinfo:eu-repo/semantics/openAccess2024-02-06T17:05:16Zoai:scielo:S0872-01692023000200057Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:09.489806Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Pediatric Nephrotoxicity: How Aware Are We? |
title |
Pediatric Nephrotoxicity: How Aware Are We? |
spellingShingle |
Pediatric Nephrotoxicity: How Aware Are We? Figueiredo,Cátia Raquel Acute Kidney Injury/complications Aminoglycosides/adverse effects Child Kidney/drug effects Kidney Diseases/chemically induced Renal Insufficiency, Chronic/chemically induced Vancomycin/adverse effects |
title_short |
Pediatric Nephrotoxicity: How Aware Are We? |
title_full |
Pediatric Nephrotoxicity: How Aware Are We? |
title_fullStr |
Pediatric Nephrotoxicity: How Aware Are We? |
title_full_unstemmed |
Pediatric Nephrotoxicity: How Aware Are We? |
title_sort |
Pediatric Nephrotoxicity: How Aware Are We? |
author |
Figueiredo,Cátia Raquel |
author_facet |
Figueiredo,Cátia Raquel Durão,Filipa Zagalo,Ana Sandes,Ana Rita Silva,José Eduardo Stone,Rosário |
author_role |
author |
author2 |
Durão,Filipa Zagalo,Ana Sandes,Ana Rita Silva,José Eduardo Stone,Rosário |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Figueiredo,Cátia Raquel Durão,Filipa Zagalo,Ana Sandes,Ana Rita Silva,José Eduardo Stone,Rosário |
dc.subject.por.fl_str_mv |
Acute Kidney Injury/complications Aminoglycosides/adverse effects Child Kidney/drug effects Kidney Diseases/chemically induced Renal Insufficiency, Chronic/chemically induced Vancomycin/adverse effects |
topic |
Acute Kidney Injury/complications Aminoglycosides/adverse effects Child Kidney/drug effects Kidney Diseases/chemically induced Renal Insufficiency, Chronic/chemically induced Vancomycin/adverse effects |
description |
ABSTRACT Vancomycin and aminoglycosides are potentially nephrotoxic broad-spectrum antibiotics, which can be used both in the treatment of severe infections and in surgical prophylaxis, in pediatric patients. Prolonged antibiotic therapy and high trough concentrations are associated with toxicity. Additionally, several individual factors contribute to nephrotoxicity increasing the risk of acute kidney injury (AKI) and consequente chronic kidney disease in the future. We developed a retrospective and observational study in the Pediatrics Department of a tertiary hospital in Portugal, to analyze clinical practice regarding monitoring and surveillance of vancomycin and aminoglycosides. The results showed low rates of monitoring, which reinforces the importance of raising awareness about this issue, recognizing its importance, and adopting preventive measures that may mitigate the risk of toxicity and improve children’s renal prognosis in adult life. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
dc.source.none.fl_str_mv |
Portuguese Journal of Nephrology & Hypertension v.37 n.2 2023 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137280896532480 |