Pediatric Nephrotoxicity: How Aware Are We?

Detalhes bibliográficos
Autor(a) principal: Figueiredo,Cátia Raquel
Data de Publicação: 2023
Outros Autores: Durão,Filipa, Zagalo,Ana, Sandes,Ana Rita, Silva,José Eduardo, Stone,Rosário
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057
Resumo: ABSTRACT Vancomycin and aminoglycosides are potentially nephrotoxic broad-spectrum antibiotics, which can be used both in the treatment of severe infections and in surgical prophylaxis, in pediatric patients. Prolonged antibiotic therapy and high trough concentrations are associated with toxicity. Additionally, several individual factors contribute to nephrotoxicity increasing the risk of acute kidney injury (AKI) and consequente chronic kidney disease in the future. We developed a retrospective and observational study in the Pediatrics Department of a tertiary hospital in Portugal, to analyze clinical practice regarding monitoring and surveillance of vancomycin and aminoglycosides. The results showed low rates of monitoring, which reinforces the importance of raising awareness about this issue, recognizing its importance, and adopting preventive measures that may mitigate the risk of toxicity and improve children’s renal prognosis in adult life.
id RCAP_f6f4c1ba3287a1aa8ba2182ae6e16f63
oai_identifier_str oai:scielo:S0872-01692023000200057
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Pediatric Nephrotoxicity: How Aware Are We?Acute Kidney Injury/complicationsAminoglycosides/adverse effectsChildKidney/drug effectsKidney Diseases/chemically inducedRenal Insufficiency, Chronic/chemically inducedVancomycin/adverse effectsABSTRACT Vancomycin and aminoglycosides are potentially nephrotoxic broad-spectrum antibiotics, which can be used both in the treatment of severe infections and in surgical prophylaxis, in pediatric patients. Prolonged antibiotic therapy and high trough concentrations are associated with toxicity. Additionally, several individual factors contribute to nephrotoxicity increasing the risk of acute kidney injury (AKI) and consequente chronic kidney disease in the future. We developed a retrospective and observational study in the Pediatrics Department of a tertiary hospital in Portugal, to analyze clinical practice regarding monitoring and surveillance of vancomycin and aminoglycosides. The results showed low rates of monitoring, which reinforces the importance of raising awareness about this issue, recognizing its importance, and adopting preventive measures that may mitigate the risk of toxicity and improve children’s renal prognosis in adult life.Sociedade Portuguesa de Nefrologia2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057Portuguese Journal of Nephrology & Hypertension v.37 n.2 2023reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057Figueiredo,Cátia RaquelDurão,FilipaZagalo,AnaSandes,Ana RitaSilva,José EduardoStone,Rosárioinfo:eu-repo/semantics/openAccess2024-02-06T17:05:16Zoai:scielo:S0872-01692023000200057Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:09.489806Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pediatric Nephrotoxicity: How Aware Are We?
title Pediatric Nephrotoxicity: How Aware Are We?
spellingShingle Pediatric Nephrotoxicity: How Aware Are We?
Figueiredo,Cátia Raquel
Acute Kidney Injury/complications
Aminoglycosides/adverse effects
Child
Kidney/drug effects
Kidney Diseases/chemically induced
Renal Insufficiency, Chronic/chemically induced
Vancomycin/adverse effects
title_short Pediatric Nephrotoxicity: How Aware Are We?
title_full Pediatric Nephrotoxicity: How Aware Are We?
title_fullStr Pediatric Nephrotoxicity: How Aware Are We?
title_full_unstemmed Pediatric Nephrotoxicity: How Aware Are We?
title_sort Pediatric Nephrotoxicity: How Aware Are We?
author Figueiredo,Cátia Raquel
author_facet Figueiredo,Cátia Raquel
Durão,Filipa
Zagalo,Ana
Sandes,Ana Rita
Silva,José Eduardo
Stone,Rosário
author_role author
author2 Durão,Filipa
Zagalo,Ana
Sandes,Ana Rita
Silva,José Eduardo
Stone,Rosário
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Figueiredo,Cátia Raquel
Durão,Filipa
Zagalo,Ana
Sandes,Ana Rita
Silva,José Eduardo
Stone,Rosário
dc.subject.por.fl_str_mv Acute Kidney Injury/complications
Aminoglycosides/adverse effects
Child
Kidney/drug effects
Kidney Diseases/chemically induced
Renal Insufficiency, Chronic/chemically induced
Vancomycin/adverse effects
topic Acute Kidney Injury/complications
Aminoglycosides/adverse effects
Child
Kidney/drug effects
Kidney Diseases/chemically induced
Renal Insufficiency, Chronic/chemically induced
Vancomycin/adverse effects
description ABSTRACT Vancomycin and aminoglycosides are potentially nephrotoxic broad-spectrum antibiotics, which can be used both in the treatment of severe infections and in surgical prophylaxis, in pediatric patients. Prolonged antibiotic therapy and high trough concentrations are associated with toxicity. Additionally, several individual factors contribute to nephrotoxicity increasing the risk of acute kidney injury (AKI) and consequente chronic kidney disease in the future. We developed a retrospective and observational study in the Pediatrics Department of a tertiary hospital in Portugal, to analyze clinical practice regarding monitoring and surveillance of vancomycin and aminoglycosides. The results showed low rates of monitoring, which reinforces the importance of raising awareness about this issue, recognizing its importance, and adopting preventive measures that may mitigate the risk of toxicity and improve children’s renal prognosis in adult life.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200057
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.37 n.2 2023
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137280896532480