Local treatments for metastases of renal cell carcinoma: a systematic review
Main Author: | |
---|---|
Publication Date: | 2014 |
Other Authors: | , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.4/1819 |
Summary: | Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across all studies. Although the findings presented here should be interpreted with caution, they and the identified gaps in knowledge should provide guidance for clinicians and researchers, and directions for further research. |
id |
RCAP_f81ba01714d360d7321df3b9c41f3768 |
---|---|
oai_identifier_str |
oai:rihuc.huc.min-saude.pt:10400.4/1819 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Local treatments for metastases of renal cell carcinoma: a systematic reviewCarcinoma de Células RenaisMetástasesLocal treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across all studies. Although the findings presented here should be interpreted with caution, they and the identified gaps in knowledge should provide guidance for clinicians and researchers, and directions for further research.RIHUCDabestani, SMarconi, LHofmann, FStewart, FLamb, TBCanfield, SEStaehler, MPowles, TLjungberg, BBex, A2015-06-23T15:35:32Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/1819engLancet Oncol. 2014 Nov;15(12):e549-61info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:23:06Zoai:rihuc.huc.min-saude.pt:10400.4/1819Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:04:16.613642Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Local treatments for metastases of renal cell carcinoma: a systematic review |
title |
Local treatments for metastases of renal cell carcinoma: a systematic review |
spellingShingle |
Local treatments for metastases of renal cell carcinoma: a systematic review Dabestani, S Carcinoma de Células Renais Metástases |
title_short |
Local treatments for metastases of renal cell carcinoma: a systematic review |
title_full |
Local treatments for metastases of renal cell carcinoma: a systematic review |
title_fullStr |
Local treatments for metastases of renal cell carcinoma: a systematic review |
title_full_unstemmed |
Local treatments for metastases of renal cell carcinoma: a systematic review |
title_sort |
Local treatments for metastases of renal cell carcinoma: a systematic review |
author |
Dabestani, S |
author_facet |
Dabestani, S Marconi, L Hofmann, F Stewart, F Lamb, TB Canfield, SE Staehler, M Powles, T Ljungberg, B Bex, A |
author_role |
author |
author2 |
Marconi, L Hofmann, F Stewart, F Lamb, TB Canfield, SE Staehler, M Powles, T Ljungberg, B Bex, A |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
RIHUC |
dc.contributor.author.fl_str_mv |
Dabestani, S Marconi, L Hofmann, F Stewart, F Lamb, TB Canfield, SE Staehler, M Powles, T Ljungberg, B Bex, A |
dc.subject.por.fl_str_mv |
Carcinoma de Células Renais Metástases |
topic |
Carcinoma de Células Renais Metástases |
description |
Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across all studies. Although the findings presented here should be interpreted with caution, they and the identified gaps in knowledge should provide guidance for clinicians and researchers, and directions for further research. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z 2015-06-23T15:35:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.4/1819 |
url |
http://hdl.handle.net/10400.4/1819 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lancet Oncol. 2014 Nov;15(12):e549-61 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131705880084480 |