Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/55412 |
Resumo: | Copyright © 2022, Paiva et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License. |
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Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcriptionEpigeneticsMemoryNeurosciencePharmacologyCopyright © 2022, Paiva et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.Caffeine is the most widely consumed psychoactive substance in the world. Strikingly, the molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumption in the mouse hippocampus using untargeted orthogonal omics techniques. Our results revealed that chronic caffeine exerts concerted pleiotropic effects in the hippocampus at the epigenomic, proteomic, and metabolomic levels. Caffeine lowered metabolism-related processes (e.g., at the level of metabolomics and gene expression) in bulk tissue, while it induced neuron-specific epigenetic changes at synaptic transmission/plasticity-related genes and increased experience-driven transcriptional activity. Altogether, these findings suggest that regular caffeine intake improves the signal-to-noise ratio during information encoding, in part through fine-tuning of metabolic genes, while boosting the salience of information processing during learning in neuronal circuits.This work was supported by grants from Hauts-de-France (PARTEN-AIRR, COGNADORA; START-AIRR, INS-SPECT) and Programme d’Investissements d’Avenir LabEx (excellence laboratory) DISTALZ (Development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer’s disease) and EGID (European Genomic Institute for Diabetes, ANR-10-LABX-46). Our laboratories are also supported by ANR (GRAND to LB; ADORATAU, ADORASTrAU, METABOTAU to DB; and BETAPLASTICITY to JSA), COEN (no. 5008), Fondation pour la Recherche Médicale, France Alzheimer/Fondation de France, FHU VasCog Research Network (Lille), Fondation Vaincre Alzheimer (ADOMEMOTAU), European Foundation for the Study of Diabetes (EFSD; to JSA), Fondation Plan Alzheimer; as well as Inserm, CNRS, Université Lille, Lille Métropole Communauté Urbaine, and DN2M. KC holds a doctoral grant from Lille University. VGM was supported by Fondation pour la Recherche Médicale (SPF20160936000). CM was supported by Région Hauts-de-France. ALB is supported by CNRS, Unistra (Strasbourg), ANR-16-CE92-0031 (EPIFUS), ANR-18-CE16-0008-02 (ADORASTrAU), Alsace Alzheimer 67, and France Alzheimer (AAP SM 2017 1664). IP is supported by Fondation pour la Recherche Médicale (SPF201909009162). CEM is grateful for support by the Alzheimer Forschung Initiative e.V. (AFI; Düsseldorf). LC was funded by SIF Italian Society of Pharmacology. RAC was supported by La Caixa Foundation (LCF/PR/HP17/52190001) and FCT (POCI-01-0145-FEDER-03127); Santa Casa da Misericórdia (MB-7-2018) and CEECIND/01497/2017 to LVL.American Society for Clinical InvestigationRepositório da Universidade de LisboaPaiva, IsabelCellai, LucreziaMeriaux, CélinePoncelet, LauranneNebie, OuadaSaliou, Jean-MichelLacoste, Anne-SophiePapegaey, AnthonyDrobecq, HervéLe Gras, StéphanieSchneider, MarionMalik, Enas M.Müller, Christa E.Faivre, EmilieCarvalho, KevinGomez-Murcia, VictoriaVieau, DidierThiroux, BryanEddarkaoui, SabihaLebouvier, ThibaudSchueller, EstelleTzeplaeff, LauraGrgurina, IrisSeguin, JonathanStauber, JonathanLopes, Luisa V.Buée, LucBuée-Scherrer, ValérieCunha, Rodrigo A.Ait-Belkacem, RimaSergeant, NicolasAnnicotte, Jean-SébastienBoutillier, Anne-LaurenceBlum, David2022-12-15T11:50:22Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55412engJ Clin Invest. 2022 Jun 15;132(12):e1493710021-973810.1172/JCI1493711558-8238info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-14T15:41:58ZPortal AgregadorONG |
| dc.title.none.fl_str_mv |
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription |
| title |
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription |
| spellingShingle |
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription Paiva, Isabel Epigenetics Memory Neuroscience Pharmacology |
| title_short |
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription |
| title_full |
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription |
| title_fullStr |
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription |
| title_full_unstemmed |
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription |
| title_sort |
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription |
| author |
Paiva, Isabel |
| author_facet |
Paiva, Isabel Cellai, Lucrezia Meriaux, Céline Poncelet, Lauranne Nebie, Ouada Saliou, Jean-Michel Lacoste, Anne-Sophie Papegaey, Anthony Drobecq, Hervé Le Gras, Stéphanie Schneider, Marion Malik, Enas M. Müller, Christa E. Faivre, Emilie Carvalho, Kevin Gomez-Murcia, Victoria Vieau, Didier Thiroux, Bryan Eddarkaoui, Sabiha Lebouvier, Thibaud Schueller, Estelle Tzeplaeff, Laura Grgurina, Iris Seguin, Jonathan Stauber, Jonathan Lopes, Luisa V. Buée, Luc Buée-Scherrer, Valérie Cunha, Rodrigo A. Ait-Belkacem, Rima Sergeant, Nicolas Annicotte, Jean-Sébastien Boutillier, Anne-Laurence Blum, David |
| author_role |
author |
| author2 |
Cellai, Lucrezia Meriaux, Céline Poncelet, Lauranne Nebie, Ouada Saliou, Jean-Michel Lacoste, Anne-Sophie Papegaey, Anthony Drobecq, Hervé Le Gras, Stéphanie Schneider, Marion Malik, Enas M. Müller, Christa E. Faivre, Emilie Carvalho, Kevin Gomez-Murcia, Victoria Vieau, Didier Thiroux, Bryan Eddarkaoui, Sabiha Lebouvier, Thibaud Schueller, Estelle Tzeplaeff, Laura Grgurina, Iris Seguin, Jonathan Stauber, Jonathan Lopes, Luisa V. Buée, Luc Buée-Scherrer, Valérie Cunha, Rodrigo A. Ait-Belkacem, Rima Sergeant, Nicolas Annicotte, Jean-Sébastien Boutillier, Anne-Laurence Blum, David |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Paiva, Isabel Cellai, Lucrezia Meriaux, Céline Poncelet, Lauranne Nebie, Ouada Saliou, Jean-Michel Lacoste, Anne-Sophie Papegaey, Anthony Drobecq, Hervé Le Gras, Stéphanie Schneider, Marion Malik, Enas M. Müller, Christa E. Faivre, Emilie Carvalho, Kevin Gomez-Murcia, Victoria Vieau, Didier Thiroux, Bryan Eddarkaoui, Sabiha Lebouvier, Thibaud Schueller, Estelle Tzeplaeff, Laura Grgurina, Iris Seguin, Jonathan Stauber, Jonathan Lopes, Luisa V. Buée, Luc Buée-Scherrer, Valérie Cunha, Rodrigo A. Ait-Belkacem, Rima Sergeant, Nicolas Annicotte, Jean-Sébastien Boutillier, Anne-Laurence Blum, David |
| dc.subject.por.fl_str_mv |
Epigenetics Memory Neuroscience Pharmacology |
| topic |
Epigenetics Memory Neuroscience Pharmacology |
| description |
Copyright © 2022, Paiva et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-12-15T11:50:22Z 2022 2022-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/55412 |
| url |
http://hdl.handle.net/10451/55412 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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J Clin Invest. 2022 Jun 15;132(12):e149371 0021-9738 10.1172/JCI149371 1558-8238 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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American Society for Clinical Investigation |
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American Society for Clinical Investigation |
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