Lúpus eritematoso sistiémico e anemia.

• Autor(a) principal: Falcão, S.
• Data de Publicação: 2007
• Outros Autores: Barros, R. C., Mateus, M, Nero, P., De Matos, A. P Alves, Pimentão, José Bravo, Ribeiro, I., Weigert, André, Branco, Jaime
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://www.scopus.com/inward/record.url?scp=34250630105&partnerID=8YFLogxK
• topic: systemic lupus erythematosus; myelodysplastic syndrome; anemia; Rheumatology

The authors report the case of a 48-years-old Caucasian women, with a previous diagnosis of systemic lupus erythematosus characterized by asthenia, fever, skin rash, alopecia, Raynaud's phenomenon, arthritis, pericardial effusion, interstitial pulmonary involvement, diffuse proliferative glomerulonephritis with crescents and anemia. The presence of severe anemia refractory to high doses of glucocorticoids (1 mg/ /Kg/day), iron therapy and blood transfusions, associated with a low reticulocyte count determined the execution of a bone marrow aspiration, biopsy and immunophenotyping, which were compatible with the diagnosis of Myelodysplastic Syndrome. The treatment with erythropoietin (5.000U 3x/week) and cyclophosphamide pulses (1 gr/m(2) month) induced complete regression of morphologic bone marrow changes and anemia. The main causes of anemia in lupus patients are discussed.