Propranolol therapy for cerebral cavernous malformations
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/137780 |
Resumo: | Funding Information: The present study was funded by IPOLFG EPE and by iNOVA4Health (UID/Multi/04462/2019) a program finan‑ cially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Educação e Ciência, through national funds. The PhD fellowship of FLC was funded by FCT (PD/BD/128337/2017). |
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Propranolol therapy for cerebral cavernous malformationsangiogenesiscerebral cavernous malformationendothelial cellsmonocytespropranololMedicine(all)Biochemistry, Genetics and Molecular Biology(all)Immunology and Microbiology(all)Funding Information: The present study was funded by IPOLFG EPE and by iNOVA4Health (UID/Multi/04462/2019) a program finan‑ cially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Educação e Ciência, through national funds. The PhD fellowship of FLC was funded by FCT (PD/BD/128337/2017).Cerebral cavernous malformations (CCMs) are vascular malformations characterized by the abnormal growth of vascular structures in the central nervous system. However, the precise mechanism(s) responsible for the development of CCM vascular abnormalities remain poorly understood. Although the mechanisms of action of propranolol in CCM have not yet been fully explored it is not commonly prescribed, it has been shown to be effective in children and appears to play a protective role in the prevention of CCM-derived hemorrhage in adults. The present study performed in vitro and ex vivo assays in order to examine the effects of propranolol on endothelial cells (ECs). The percentage of CD14+/CD31+ cells and the levels of VEGF in the peripheral blood (PB) of a child patient with CCM, with recurrent seizures and hemorrhages, who was maintained under propranolol therapy, were also analyzed. In addition to the effects of propranolol on differentiated ECs, and the decrease angiogenic-related features in vitro and ex vivo, it was observed that in the PB of this patient, propranolol administration decreased the percentage of circulating cells sharing monocytic and EC features (CD14+/CD31+ cells), as well as the VEGF levels; this was concomitant with a good prognosis and with the reversion of CCM lesions. A decrease in VEGF levels by propranolol may also be involved in the impairment of the recruitment of CD14+/CD31+ monocytes functioning as endothelial progenitor cells to sustain the vascular lesion. On the whole, the present study demonstrates that propranolol impairs angiogenesis in vitro and may thus be a useful tool for the clinical management of CCM. Moreover, the present study highlights the monitorization of the levels of CD14+/CD31+ monocytes and VEGF levels as a useful tool for predicting the clinical efficacy of propranolol in patients with CCM.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNLopes-Coelho, FilipaNunes, SofiaMartins, FilipaHipolito, AnaGouveia-Fernandes, SofiaDomingues, GermanaMelo, Bernardete F.Sacramento, Joana F.Conde, Sílvia V.Pereira, Sofia A.Vinhais, SofiaSalgado, DuarteSerpa, Jacinta2022-05-11T22:48:19Z2022-04-062022-04-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/137780eng2632-2900PURE: 43678743https://doi.org/10.3892/wasj.2022.158info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:15:13Zoai:run.unl.pt:10362/137780Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:53.502022Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Propranolol therapy for cerebral cavernous malformations |
| title |
Propranolol therapy for cerebral cavernous malformations |
| spellingShingle |
Propranolol therapy for cerebral cavernous malformations Lopes-Coelho, Filipa angiogenesis cerebral cavernous malformation endothelial cells monocytes propranolol Medicine(all) Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) |
| title_short |
Propranolol therapy for cerebral cavernous malformations |
| title_full |
Propranolol therapy for cerebral cavernous malformations |
| title_fullStr |
Propranolol therapy for cerebral cavernous malformations |
| title_full_unstemmed |
Propranolol therapy for cerebral cavernous malformations |
| title_sort |
Propranolol therapy for cerebral cavernous malformations |
| author |
Lopes-Coelho, Filipa |
| author_facet |
Lopes-Coelho, Filipa Nunes, Sofia Martins, Filipa Hipolito, Ana Gouveia-Fernandes, Sofia Domingues, Germana Melo, Bernardete F. Sacramento, Joana F. Conde, Sílvia V. Pereira, Sofia A. Vinhais, Sofia Salgado, Duarte Serpa, Jacinta |
| author_role |
author |
| author2 |
Nunes, Sofia Martins, Filipa Hipolito, Ana Gouveia-Fernandes, Sofia Domingues, Germana Melo, Bernardete F. Sacramento, Joana F. Conde, Sílvia V. Pereira, Sofia A. Vinhais, Sofia Salgado, Duarte Serpa, Jacinta |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
| dc.contributor.author.fl_str_mv |
Lopes-Coelho, Filipa Nunes, Sofia Martins, Filipa Hipolito, Ana Gouveia-Fernandes, Sofia Domingues, Germana Melo, Bernardete F. Sacramento, Joana F. Conde, Sílvia V. Pereira, Sofia A. Vinhais, Sofia Salgado, Duarte Serpa, Jacinta |
| dc.subject.por.fl_str_mv |
angiogenesis cerebral cavernous malformation endothelial cells monocytes propranolol Medicine(all) Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) |
| topic |
angiogenesis cerebral cavernous malformation endothelial cells monocytes propranolol Medicine(all) Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) |
| description |
Funding Information: The present study was funded by IPOLFG EPE and by iNOVA4Health (UID/Multi/04462/2019) a program finan‑ cially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Educação e Ciência, through national funds. The PhD fellowship of FLC was funded by FCT (PD/BD/128337/2017). |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-05-11T22:48:19Z 2022-04-06 2022-04-06T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/137780 |
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http://hdl.handle.net/10362/137780 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2632-2900 PURE: 43678743 https://doi.org/10.3892/wasj.2022.158 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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