The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19

Detalhes bibliográficos
Autor(a) principal: Sampaio, Samira Costa
Data de Publicação: 2022
Outros Autores: Sacramento, Gabriel Santos, de Almeida, Jessica Bomfim
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Revista Ciências em Saúde
Texto Completo: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1275
Resumo: SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) emerged in China exponentially and is recognized as a multisystem disease that gradually elevates markers associated with iron metabolism as the infection becomes more intense, becoming a critical factor in the investigation of prognosis. We review the latest scientific findings on the behavior of iron and ferritin in pathophysiology and as laboratory markers in COVID-19 (Coronavirus Disease 2019).The findings showed that iron and ferritin play a key role in the pathogenesis of COVID-19, contributing to the worsening of the disease. Therefore, iron dysmetabolism, marked by hyperferritinemia, is associated with inflammatory states in SARS-CoV-2 infection, and ferritin measurement has been shown to be a useful laboratory marker with a clinical and discriminatory potential to define the severity and mortality during COVID-19.
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spelling The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19O papel do ferro e da ferritina na fisiopatologia e como marcador laboratorial na COVID-19BiomarkerCOVID-19FerritinIronPrognosisSARS-CoV-2BiomarcadorCOVID-19FerritinaFerroPrognósticoSARS-CoV-2SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) emerged in China exponentially and is recognized as a multisystem disease that gradually elevates markers associated with iron metabolism as the infection becomes more intense, becoming a critical factor in the investigation of prognosis. We review the latest scientific findings on the behavior of iron and ferritin in pathophysiology and as laboratory markers in COVID-19 (Coronavirus Disease 2019).The findings showed that iron and ferritin play a key role in the pathogenesis of COVID-19, contributing to the worsening of the disease. Therefore, iron dysmetabolism, marked by hyperferritinemia, is associated with inflammatory states in SARS-CoV-2 infection, and ferritin measurement has been shown to be a useful laboratory marker with a clinical and discriminatory potential to define the severity and mortality during COVID-19.O SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) surgiu na China, de maneira exponencial e foi reconhecida como uma doença multissistêmica que eleva gradativamente marcadores associados ao metabolismo do ferro à medida que a infecção se torna mais intensa, sendo fator chave na investigação de prognóstico. Analisamos as últimas descobertas científicas sobre o comportamento do ferro e da ferritina na fisiopatologia e como marcador laboratorial na COVID-19 (Coronavirus Disease 2019). As descobertas evidenciaram que o ferro e a ferritina tem papel chave na patogênese da COVID-19 contribuindo para o agravamento da doença. Portanto, o dismetabolismo do ferro, marcado pela hiperferritinemia, está associado a estados inflamatórios na infecção por SARS-CoV-2 e a dosagem de ferritina mostrou ser um marcador laboratorial útil, com um potencial clínico e discriminatório para definir a gravidade e mortalidade durante o curso do COVID-19.AISI/HCI2022-08-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos parestextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/127510.21876/rcshci.v12i3.1275Revista Ciências em Saúde; v. 12 n. 3 (2022): Julho a Setembro de 2022; 12-21Health Sciences Journal; Vol 12 No 3 (2022): July to September 2022; 12-212236-378510.21876/rcshci.v12i3reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIengporhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1275/819https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1275/820Copyright (c) 2022 Revista Ciências em Saúdehttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessSampaio, Samira CostaSacramento, Gabriel Santosde Almeida, Jessica Bomfim2022-09-15T18:27:35Zoai:ojs.portalrcs.hcitajuba.org.br:article/1275Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2022-09-15T18:27:35Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse
dc.title.none.fl_str_mv The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19
O papel do ferro e da ferritina na fisiopatologia e como marcador laboratorial na COVID-19
title The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19
spellingShingle The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19
Sampaio, Samira Costa
Biomarker
COVID-19
Ferritin
Iron
Prognosis
SARS-CoV-2
Biomarcador
COVID-19
Ferritina
Ferro
Prognóstico
SARS-CoV-2
title_short The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19
title_full The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19
title_fullStr The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19
title_full_unstemmed The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19
title_sort The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19
author Sampaio, Samira Costa
author_facet Sampaio, Samira Costa
Sacramento, Gabriel Santos
de Almeida, Jessica Bomfim
author_role author
author2 Sacramento, Gabriel Santos
de Almeida, Jessica Bomfim
author2_role author
author
dc.contributor.author.fl_str_mv Sampaio, Samira Costa
Sacramento, Gabriel Santos
de Almeida, Jessica Bomfim
dc.subject.por.fl_str_mv Biomarker
COVID-19
Ferritin
Iron
Prognosis
SARS-CoV-2
Biomarcador
COVID-19
Ferritina
Ferro
Prognóstico
SARS-CoV-2
topic Biomarker
COVID-19
Ferritin
Iron
Prognosis
SARS-CoV-2
Biomarcador
COVID-19
Ferritina
Ferro
Prognóstico
SARS-CoV-2
description SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) emerged in China exponentially and is recognized as a multisystem disease that gradually elevates markers associated with iron metabolism as the infection becomes more intense, becoming a critical factor in the investigation of prognosis. We review the latest scientific findings on the behavior of iron and ferritin in pathophysiology and as laboratory markers in COVID-19 (Coronavirus Disease 2019).The findings showed that iron and ferritin play a key role in the pathogenesis of COVID-19, contributing to the worsening of the disease. Therefore, iron dysmetabolism, marked by hyperferritinemia, is associated with inflammatory states in SARS-CoV-2 infection, and ferritin measurement has been shown to be a useful laboratory marker with a clinical and discriminatory potential to define the severity and mortality during COVID-19.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer reviewed
Avaliado pelos pares
texto
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1275
10.21876/rcshci.v12i3.1275
url https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1275
identifier_str_mv 10.21876/rcshci.v12i3.1275
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1275/819
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1275/820
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Ciências em Saúde
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Ciências em Saúde
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AISI/HCI
publisher.none.fl_str_mv AISI/HCI
dc.source.none.fl_str_mv Revista Ciências em Saúde; v. 12 n. 3 (2022): Julho a Setembro de 2022; 12-21
Health Sciences Journal; Vol 12 No 3 (2022): July to September 2022; 12-21
2236-3785
10.21876/rcshci.v12i3
reponame:Revista Ciências em Saúde
instname:Hospital de Clínicas de Itajubá
instacron:HCI
instname_str Hospital de Clínicas de Itajubá
instacron_str HCI
institution HCI
reponame_str Revista Ciências em Saúde
collection Revista Ciências em Saúde
repository.name.fl_str_mv Revista Ciências em Saúde - Hospital de Clínicas de Itajubá
repository.mail.fl_str_mv rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br
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