Abdominal aortic aneurysm model in swine with bovine pericardium patch
Main Author: | |
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Publication Date: | 2021 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Jornal Vascular Brasileiro (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492021000100326 |
Summary: | Abstract Background Aneurysm repair using endovascular techniques has grown in importance as materials have improved. Studies of endovascular prostheses require experimental models that reproduce anatomic and pathophysiological characteristics of human aneurysms. Objectives To describe a porcine model of abdominal aortic aneurysm. Methods This prospective cohort study used eleven Large White female pigs with a mean age of 12 weeks in two study phases. In phase I, the aneurysm was produced with a bovine pericardium patch by retroperitoneal surgery conducted under general anesthesia. In phase II, 15 days later, the animals underwent arteriography and were then euthanized before specimens were removed for histological analysis. Results Formation of parietal thrombus was observed in all animals. Microscopic analysis showed calcifications around thrombus in 82% of the animals. There was lymphoplasmacytic infiltration in the graft and adjacent area, with fibrosis in nine animals. Three pigs had substantial myointimal thickening, and eight had microcalcifications. Mortality was zero, and there were no ruptures, ischemia, or surgery site infections. Conclusions This is a unique model, using inexpensive, biocompatible material. Bovine pericardium is easy for the surgeon to handle and has very similar characteristics to autologous tissue in terms of integration with the cell wall. |
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Abdominal aortic aneurysm model in swine with bovine pericardium patchabdominal aortic aneurysmaortic aneurysmaneurysmAbstract Background Aneurysm repair using endovascular techniques has grown in importance as materials have improved. Studies of endovascular prostheses require experimental models that reproduce anatomic and pathophysiological characteristics of human aneurysms. Objectives To describe a porcine model of abdominal aortic aneurysm. Methods This prospective cohort study used eleven Large White female pigs with a mean age of 12 weeks in two study phases. In phase I, the aneurysm was produced with a bovine pericardium patch by retroperitoneal surgery conducted under general anesthesia. In phase II, 15 days later, the animals underwent arteriography and were then euthanized before specimens were removed for histological analysis. Results Formation of parietal thrombus was observed in all animals. Microscopic analysis showed calcifications around thrombus in 82% of the animals. There was lymphoplasmacytic infiltration in the graft and adjacent area, with fibrosis in nine animals. Three pigs had substantial myointimal thickening, and eight had microcalcifications. Mortality was zero, and there were no ruptures, ischemia, or surgery site infections. Conclusions This is a unique model, using inexpensive, biocompatible material. Bovine pericardium is easy for the surgeon to handle and has very similar characteristics to autologous tissue in terms of integration with the cell wall.Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV)2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492021000100326Jornal Vascular Brasileiro v.20 2021reponame:Jornal Vascular Brasileiro (Online)instname:Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV)instacron:SBACV10.1590/1677-5449.210080info:eu-repo/semantics/openAccessPerini,Sílvio CésarBertolucci,Leonardo HenriqueMartins,Ana Paula DonadelloFrança,Luís Henrique GilAveline,Celso CurcioPereira,Adamastor Humbertoeng2021-08-30T00:00:00Zoai:scielo:S1677-54492021000100326Revistahttp://www.scielo.br/jvbhttps://old.scielo.br/oai/scielo-oai.php||secretaria@sbacv.org.br1677-73011677-5449opendoar:2021-08-30T00:00Jornal Vascular Brasileiro (Online) - Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV)false |
dc.title.none.fl_str_mv |
Abdominal aortic aneurysm model in swine with bovine pericardium patch |
title |
Abdominal aortic aneurysm model in swine with bovine pericardium patch |
spellingShingle |
Abdominal aortic aneurysm model in swine with bovine pericardium patch Perini,Sílvio César abdominal aortic aneurysm aortic aneurysm aneurysm |
title_short |
Abdominal aortic aneurysm model in swine with bovine pericardium patch |
title_full |
Abdominal aortic aneurysm model in swine with bovine pericardium patch |
title_fullStr |
Abdominal aortic aneurysm model in swine with bovine pericardium patch |
title_full_unstemmed |
Abdominal aortic aneurysm model in swine with bovine pericardium patch |
title_sort |
Abdominal aortic aneurysm model in swine with bovine pericardium patch |
author |
Perini,Sílvio César |
author_facet |
Perini,Sílvio César Bertolucci,Leonardo Henrique Martins,Ana Paula Donadello França,Luís Henrique Gil Aveline,Celso Curcio Pereira,Adamastor Humberto |
author_role |
author |
author2 |
Bertolucci,Leonardo Henrique Martins,Ana Paula Donadello França,Luís Henrique Gil Aveline,Celso Curcio Pereira,Adamastor Humberto |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Perini,Sílvio César Bertolucci,Leonardo Henrique Martins,Ana Paula Donadello França,Luís Henrique Gil Aveline,Celso Curcio Pereira,Adamastor Humberto |
dc.subject.por.fl_str_mv |
abdominal aortic aneurysm aortic aneurysm aneurysm |
topic |
abdominal aortic aneurysm aortic aneurysm aneurysm |
description |
Abstract Background Aneurysm repair using endovascular techniques has grown in importance as materials have improved. Studies of endovascular prostheses require experimental models that reproduce anatomic and pathophysiological characteristics of human aneurysms. Objectives To describe a porcine model of abdominal aortic aneurysm. Methods This prospective cohort study used eleven Large White female pigs with a mean age of 12 weeks in two study phases. In phase I, the aneurysm was produced with a bovine pericardium patch by retroperitoneal surgery conducted under general anesthesia. In phase II, 15 days later, the animals underwent arteriography and were then euthanized before specimens were removed for histological analysis. Results Formation of parietal thrombus was observed in all animals. Microscopic analysis showed calcifications around thrombus in 82% of the animals. There was lymphoplasmacytic infiltration in the graft and adjacent area, with fibrosis in nine animals. Three pigs had substantial myointimal thickening, and eight had microcalcifications. Mortality was zero, and there were no ruptures, ischemia, or surgery site infections. Conclusions This is a unique model, using inexpensive, biocompatible material. Bovine pericardium is easy for the surgeon to handle and has very similar characteristics to autologous tissue in terms of integration with the cell wall. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492021000100326 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492021000100326 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1677-5449.210080 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV) |
publisher.none.fl_str_mv |
Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV) |
dc.source.none.fl_str_mv |
Jornal Vascular Brasileiro v.20 2021 reponame:Jornal Vascular Brasileiro (Online) instname:Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV) instacron:SBACV |
instname_str |
Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV) |
instacron_str |
SBACV |
institution |
SBACV |
reponame_str |
Jornal Vascular Brasileiro (Online) |
collection |
Jornal Vascular Brasileiro (Online) |
repository.name.fl_str_mv |
Jornal Vascular Brasileiro (Online) - Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV) |
repository.mail.fl_str_mv |
||secretaria@sbacv.org.br |
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1752126648888590336 |