USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHY
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Data de Publicação: | 2015 |
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Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Ensino de Bioquímica |
Texto Completo: | http://bioquimica.org.br/revista/ojs/index.php/REB/article/view/574 |
Resumo: | Introduction The X-linked adrenoleukodystrophy (X-ALD) is characterized by mutations in very long chain fatty acids (VLCFA) peroxisome transporter, leading to VLCFA accumulation in myelin sheath. In the 70’s and 80’s it was hypothesized that X-ALD is caused by enzymatic deficits in FA-coenzyme A connection, VLCFA degradation or FA elongation. The latter enabled Lorenzo’s oil (LO) treatment, which became famous by the homonym movie. The apparent initial therapy effectiveness lead to LO administration in many patients, although with biochemical knowledge progress its relevance has been questioned.Objectives Our aim was to discuss X-ALD researches in “Lipids Metabolism” classes during 2014 Biochemistry courses to Biology and Biomedicine undergraduate students at Fluminense Federal University to illustrate how scientific knowledge is constructed.Materials and MethodsIn order to contrast the recent scientific advances with the information spread to society through “Lorenzo’s Oil”, the movie in edited version was presented to students followed by a questionnaire with Likert scale to evaluate the perception of scientific knowledge exposed by the movie. Afterwards, a Guided Study containing a brief history and discursive questions based upon a paper (Wiesingner et.al, J. Biol. Chem. 288:19269, 2013) was applied in class.Results and DiscussionFrom 58 students who filled in the questionnaire,72,4% considered the movie shows that X-ALD biochemical knowledge has been achieved. This notion was confirmed since 84,5% agreed LO is an effective alternative treatment if X-ALD is early detected. The same percentage agreed that based on the movie the biochemical deficiency relies on an enzyme involved in VLCFA degradation. Although the movie transmits the idea that the cure has been found, 67,2% believed X-ALD biochemical mechanisms are not fully comprehended. ConclusionsThe Guided Study/movie application was very effective because allowed the understanding of mechanisms completely unknown by the time of LO development and also the comprehension of scientific knowledge construction through a playful and participative activity.AcknowledgementsWe thank Prograd-UFF for scholarship supply.Key wordsAdrenoleukodystrophy; Biochemistry teaching; scientific knowledge |
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USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHYAdrenoleukodystrophy; Biochemistry teaching; scientific knowledgeIntroduction The X-linked adrenoleukodystrophy (X-ALD) is characterized by mutations in very long chain fatty acids (VLCFA) peroxisome transporter, leading to VLCFA accumulation in myelin sheath. In the 70’s and 80’s it was hypothesized that X-ALD is caused by enzymatic deficits in FA-coenzyme A connection, VLCFA degradation or FA elongation. The latter enabled Lorenzo’s oil (LO) treatment, which became famous by the homonym movie. The apparent initial therapy effectiveness lead to LO administration in many patients, although with biochemical knowledge progress its relevance has been questioned.Objectives Our aim was to discuss X-ALD researches in “Lipids Metabolism” classes during 2014 Biochemistry courses to Biology and Biomedicine undergraduate students at Fluminense Federal University to illustrate how scientific knowledge is constructed.Materials and MethodsIn order to contrast the recent scientific advances with the information spread to society through “Lorenzo’s Oil”, the movie in edited version was presented to students followed by a questionnaire with Likert scale to evaluate the perception of scientific knowledge exposed by the movie. Afterwards, a Guided Study containing a brief history and discursive questions based upon a paper (Wiesingner et.al, J. Biol. Chem. 288:19269, 2013) was applied in class.Results and DiscussionFrom 58 students who filled in the questionnaire,72,4% considered the movie shows that X-ALD biochemical knowledge has been achieved. This notion was confirmed since 84,5% agreed LO is an effective alternative treatment if X-ALD is early detected. The same percentage agreed that based on the movie the biochemical deficiency relies on an enzyme involved in VLCFA degradation. Although the movie transmits the idea that the cure has been found, 67,2% believed X-ALD biochemical mechanisms are not fully comprehended. ConclusionsThe Guided Study/movie application was very effective because allowed the understanding of mechanisms completely unknown by the time of LO development and also the comprehension of scientific knowledge construction through a playful and participative activity.AcknowledgementsWe thank Prograd-UFF for scholarship supply.Key wordsAdrenoleukodystrophy; Biochemistry teaching; scientific knowledgeSociedade Brasileira de Bioquímica e Biologia Molecular - SBBqPrograd-UFFGagianone, R. B.Ribeiro, M. G.L.2015-08-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionResumos SBBq - avaliados pelos paresSBBq resúmenes - revisada por paresSBBq abstracts / peer-reviewedapplication/pdfhttp://bioquimica.org.br/revista/ojs/index.php/REB/article/view/57410.16923/reb.v13i2.574Revista de Ensino de Bioquímica; v. 13 (2015): Especial eventos; 6Revista de Enseñanza de Bioquímica; v. 13 (2015): Especial eventos; 6Journal of Biochemistry Education; v. 13 (2015): Especial eventos; 6Revista de Ensino de Bioquímica; v. 13 (2015): Especial eventos; 62318-8790reponame:Revista de Ensino de Bioquímicainstname:Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq)instacron:SBBQMporhttp://bioquimica.org.br/revista/ojs/index.php/REB/article/view/574/474Direitos autorais 2015 Revista de Ensino de Bioquímicahttp://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccess2022-03-25T17:25:03Zoai:ojs.bioquimica.org.br:article/574Revistahttp://bioquimica.org.br/revista/ojs/index.php/REBONGhttp://bioquimica.org.br/revista/ojs/index.php/REB/oaicontato@bioquimica.org.br||ensinodebioquimica@gmail.com2318-87901677-2318opendoar:2022-03-25T17:25:03Revista de Ensino de Bioquímica - Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq)false |
dc.title.none.fl_str_mv |
USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHY |
title |
USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHY |
spellingShingle |
USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHY Gagianone, R. B. Adrenoleukodystrophy; Biochemistry teaching; scientific knowledge |
title_short |
USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHY |
title_full |
USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHY |
title_fullStr |
USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHY |
title_full_unstemmed |
USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHY |
title_sort |
USING SCIENTIFIC PAPERS TO STIMULATE THE STUDY OF BIOCHEMISTRY AND THE UNDERSTANDING OF SCIENTIFIC KNOWLEDGE CONSTRUCTION: THE RESEARCH ON ADRENOLEUKODYSTROPHY |
author |
Gagianone, R. B. |
author_facet |
Gagianone, R. B. Ribeiro, M. G.L. |
author_role |
author |
author2 |
Ribeiro, M. G.L. |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Prograd-UFF |
dc.contributor.author.fl_str_mv |
Gagianone, R. B. Ribeiro, M. G.L. |
dc.subject.none.fl_str_mv |
|
dc.subject.por.fl_str_mv |
Adrenoleukodystrophy; Biochemistry teaching; scientific knowledge |
topic |
Adrenoleukodystrophy; Biochemistry teaching; scientific knowledge |
description |
Introduction The X-linked adrenoleukodystrophy (X-ALD) is characterized by mutations in very long chain fatty acids (VLCFA) peroxisome transporter, leading to VLCFA accumulation in myelin sheath. In the 70’s and 80’s it was hypothesized that X-ALD is caused by enzymatic deficits in FA-coenzyme A connection, VLCFA degradation or FA elongation. The latter enabled Lorenzo’s oil (LO) treatment, which became famous by the homonym movie. The apparent initial therapy effectiveness lead to LO administration in many patients, although with biochemical knowledge progress its relevance has been questioned.Objectives Our aim was to discuss X-ALD researches in “Lipids Metabolism” classes during 2014 Biochemistry courses to Biology and Biomedicine undergraduate students at Fluminense Federal University to illustrate how scientific knowledge is constructed.Materials and MethodsIn order to contrast the recent scientific advances with the information spread to society through “Lorenzo’s Oil”, the movie in edited version was presented to students followed by a questionnaire with Likert scale to evaluate the perception of scientific knowledge exposed by the movie. Afterwards, a Guided Study containing a brief history and discursive questions based upon a paper (Wiesingner et.al, J. Biol. Chem. 288:19269, 2013) was applied in class.Results and DiscussionFrom 58 students who filled in the questionnaire,72,4% considered the movie shows that X-ALD biochemical knowledge has been achieved. This notion was confirmed since 84,5% agreed LO is an effective alternative treatment if X-ALD is early detected. The same percentage agreed that based on the movie the biochemical deficiency relies on an enzyme involved in VLCFA degradation. Although the movie transmits the idea that the cure has been found, 67,2% believed X-ALD biochemical mechanisms are not fully comprehended. ConclusionsThe Guided Study/movie application was very effective because allowed the understanding of mechanisms completely unknown by the time of LO development and also the comprehension of scientific knowledge construction through a playful and participative activity.AcknowledgementsWe thank Prograd-UFF for scholarship supply.Key wordsAdrenoleukodystrophy; Biochemistry teaching; scientific knowledge |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-24 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Resumos SBBq - avaliados pelos pares SBBq resúmenes - revisada por pares SBBq abstracts / peer-reviewed |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://bioquimica.org.br/revista/ojs/index.php/REB/article/view/574 10.16923/reb.v13i2.574 |
url |
http://bioquimica.org.br/revista/ojs/index.php/REB/article/view/574 |
identifier_str_mv |
10.16923/reb.v13i2.574 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
http://bioquimica.org.br/revista/ojs/index.php/REB/article/view/574/474 |
dc.rights.driver.fl_str_mv |
Direitos autorais 2015 Revista de Ensino de Bioquímica http://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos autorais 2015 Revista de Ensino de Bioquímica http://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.coverage.none.fl_str_mv |
|
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq |
publisher.none.fl_str_mv |
Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq |
dc.source.none.fl_str_mv |
Revista de Ensino de Bioquímica; v. 13 (2015): Especial eventos; 6 Revista de Enseñanza de Bioquímica; v. 13 (2015): Especial eventos; 6 Journal of Biochemistry Education; v. 13 (2015): Especial eventos; 6 Revista de Ensino de Bioquímica; v. 13 (2015): Especial eventos; 6 2318-8790 reponame:Revista de Ensino de Bioquímica instname:Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq) instacron:SBBQM |
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Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq) |
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SBBQM |
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SBBQM |
reponame_str |
Revista de Ensino de Bioquímica |
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Revista de Ensino de Bioquímica |
repository.name.fl_str_mv |
Revista de Ensino de Bioquímica - Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq) |
repository.mail.fl_str_mv |
contato@bioquimica.org.br||ensinodebioquimica@gmail.com |
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