Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Cardiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001500364 |
Resumo: | Abstract Background: Chagas Disease (CD) is an important cause of morbimortality due to heart failure and malignant arrhythmias worldwide, especially in Latin America. Objective: To investigate the association of obstructive sleep apnea (OSA) with heart remodeling and cardiac arrhythmias in patients CD. Methods: Consecutive patients with CD, aged between 30 to 65 years old were enrolled. Participants underwent clinical evaluation, sleep study, 24-hour Holter monitoring, echocardiogram and ambulatory blood pressure monitoring. Results: We evaluated 135 patients [age: 56 (45-62) years; 30% men; BMI: 26 ± 4 kg/m2, Chagas cardiomyopathy: 70%]. Moderate to severe OSA (apnea-hypopnea index, AHI, ≥ 15 events/h) was present in 21% of the patients. OSA was not associated with arrhythmias in this population. As compared to patients with mild or no OSA, patients with moderate to severe OSA had higher frequency of hypertension (79% vs. 72% vs. 44%, p < 0.01) higher nocturnal systolic blood pressure: 119 ± 17 vs. 113 ± 13 vs. 110 ± 11 mmHg, p = 0.01; larger left atrial diameter [37 (33-42) vs. 35 (33-39) vs. 33 (30-36) mm, p < 0.01]; and a greater proportion of left ventricular dysfunction [LVEF < 50% (39% vs. 28% vs. 11%), p < 0.01], respectively. Predictor of left atrial dimension was Log10 (AHI) (b = 3.86, 95% CI: 1.91 to 5.81; p < 0.01). Predictors of ventricular dysfunction were AHI > 15 events/h (OR = 3.61, 95% CI: 1.31 - 9.98; p = 0.01), systolic blood pressure (OR = 1.06, 95% CI: 1.02 - 1.10; p < 0.01) and male gender (OR = 3.24, 95% CI: 1.31 - 8.01; p = 0.01). Conclusions: OSA is independently associated with atrial and ventricular remodeling in patients with CD. |
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Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas DiseaseChagas DiseaseSleep Apnea, ObstructiveVentricular RemodelingArrhythmias, CardiacAbstract Background: Chagas Disease (CD) is an important cause of morbimortality due to heart failure and malignant arrhythmias worldwide, especially in Latin America. Objective: To investigate the association of obstructive sleep apnea (OSA) with heart remodeling and cardiac arrhythmias in patients CD. Methods: Consecutive patients with CD, aged between 30 to 65 years old were enrolled. Participants underwent clinical evaluation, sleep study, 24-hour Holter monitoring, echocardiogram and ambulatory blood pressure monitoring. Results: We evaluated 135 patients [age: 56 (45-62) years; 30% men; BMI: 26 ± 4 kg/m2, Chagas cardiomyopathy: 70%]. Moderate to severe OSA (apnea-hypopnea index, AHI, ≥ 15 events/h) was present in 21% of the patients. OSA was not associated with arrhythmias in this population. As compared to patients with mild or no OSA, patients with moderate to severe OSA had higher frequency of hypertension (79% vs. 72% vs. 44%, p < 0.01) higher nocturnal systolic blood pressure: 119 ± 17 vs. 113 ± 13 vs. 110 ± 11 mmHg, p = 0.01; larger left atrial diameter [37 (33-42) vs. 35 (33-39) vs. 33 (30-36) mm, p < 0.01]; and a greater proportion of left ventricular dysfunction [LVEF < 50% (39% vs. 28% vs. 11%), p < 0.01], respectively. Predictor of left atrial dimension was Log10 (AHI) (b = 3.86, 95% CI: 1.91 to 5.81; p < 0.01). Predictors of ventricular dysfunction were AHI > 15 events/h (OR = 3.61, 95% CI: 1.31 - 9.98; p = 0.01), systolic blood pressure (OR = 1.06, 95% CI: 1.02 - 1.10; p < 0.01) and male gender (OR = 3.24, 95% CI: 1.31 - 8.01; p = 0.01). Conclusions: OSA is independently associated with atrial and ventricular remodeling in patients with CD.Sociedade Brasileira de Cardiologia - SBC2018-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001500364Arquivos Brasileiros de Cardiologia v.111 n.3 2018reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20180131info:eu-repo/semantics/openAccessMedeiros,Carolina de AraújoSecundo,Isaac VieiraSilveira,Carlos Antônio da MotaCastilho,José Maria delAlbuquerque,Afonso Luiz Tavares deMartins,Sílvia MarinhoOliveira Júnior,Wilson deLorenzi-Filho,GeraldoDrager,Luciano F.Pedrosa,Rodrigo Pintoeng2019-04-18T00:00:00Zoai:scielo:S0066-782X2018001500364Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2019-04-18T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease |
title |
Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease |
spellingShingle |
Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease Medeiros,Carolina de Araújo Chagas Disease Sleep Apnea, Obstructive Ventricular Remodeling Arrhythmias, Cardiac |
title_short |
Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease |
title_full |
Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease |
title_fullStr |
Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease |
title_full_unstemmed |
Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease |
title_sort |
Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease |
author |
Medeiros,Carolina de Araújo |
author_facet |
Medeiros,Carolina de Araújo Secundo,Isaac Vieira Silveira,Carlos Antônio da Mota Castilho,José Maria del Albuquerque,Afonso Luiz Tavares de Martins,Sílvia Marinho Oliveira Júnior,Wilson de Lorenzi-Filho,Geraldo Drager,Luciano F. Pedrosa,Rodrigo Pinto |
author_role |
author |
author2 |
Secundo,Isaac Vieira Silveira,Carlos Antônio da Mota Castilho,José Maria del Albuquerque,Afonso Luiz Tavares de Martins,Sílvia Marinho Oliveira Júnior,Wilson de Lorenzi-Filho,Geraldo Drager,Luciano F. Pedrosa,Rodrigo Pinto |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Medeiros,Carolina de Araújo Secundo,Isaac Vieira Silveira,Carlos Antônio da Mota Castilho,José Maria del Albuquerque,Afonso Luiz Tavares de Martins,Sílvia Marinho Oliveira Júnior,Wilson de Lorenzi-Filho,Geraldo Drager,Luciano F. Pedrosa,Rodrigo Pinto |
dc.subject.por.fl_str_mv |
Chagas Disease Sleep Apnea, Obstructive Ventricular Remodeling Arrhythmias, Cardiac |
topic |
Chagas Disease Sleep Apnea, Obstructive Ventricular Remodeling Arrhythmias, Cardiac |
description |
Abstract Background: Chagas Disease (CD) is an important cause of morbimortality due to heart failure and malignant arrhythmias worldwide, especially in Latin America. Objective: To investigate the association of obstructive sleep apnea (OSA) with heart remodeling and cardiac arrhythmias in patients CD. Methods: Consecutive patients with CD, aged between 30 to 65 years old were enrolled. Participants underwent clinical evaluation, sleep study, 24-hour Holter monitoring, echocardiogram and ambulatory blood pressure monitoring. Results: We evaluated 135 patients [age: 56 (45-62) years; 30% men; BMI: 26 ± 4 kg/m2, Chagas cardiomyopathy: 70%]. Moderate to severe OSA (apnea-hypopnea index, AHI, ≥ 15 events/h) was present in 21% of the patients. OSA was not associated with arrhythmias in this population. As compared to patients with mild or no OSA, patients with moderate to severe OSA had higher frequency of hypertension (79% vs. 72% vs. 44%, p < 0.01) higher nocturnal systolic blood pressure: 119 ± 17 vs. 113 ± 13 vs. 110 ± 11 mmHg, p = 0.01; larger left atrial diameter [37 (33-42) vs. 35 (33-39) vs. 33 (30-36) mm, p < 0.01]; and a greater proportion of left ventricular dysfunction [LVEF < 50% (39% vs. 28% vs. 11%), p < 0.01], respectively. Predictor of left atrial dimension was Log10 (AHI) (b = 3.86, 95% CI: 1.91 to 5.81; p < 0.01). Predictors of ventricular dysfunction were AHI > 15 events/h (OR = 3.61, 95% CI: 1.31 - 9.98; p = 0.01), systolic blood pressure (OR = 1.06, 95% CI: 1.02 - 1.10; p < 0.01) and male gender (OR = 3.24, 95% CI: 1.31 - 8.01; p = 0.01). Conclusions: OSA is independently associated with atrial and ventricular remodeling in patients with CD. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001500364 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001500364 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/abc.20180131 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia v.111 n.3 2018 reponame:Arquivos Brasileiros de Cardiologia (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
Arquivos Brasileiros de Cardiologia (Online) |
collection |
Arquivos Brasileiros de Cardiologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
||arquivos@cardiol.br |
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1752126568728100864 |