Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve

Detalhes bibliográficos
Autor(a) principal: Costantini,Costantino Roberto Frack
Data de Publicação: 2017
Outros Autores: Ramires,Jose Antonio, Costantini,Costantino Ortiz, Denk,Marcos Antonio, Tarbine,Sergio Gustavo, Santos,Marcelo de Freitas, Zanuttini,Daniel Aníbal, Silveira,Carmen Weigert, Souza,Admar Moraes de, Macedo,Rafael Michel de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000100038
Resumo: Abstract Background: Functional assessment of coronary artery obstruction is used in cardiology practice to correlate anatomic obstructions with flow decrease. Among such assessments, the study of the coronary fractional flow reserve (FFR) has become the most widely used. Objective: To evaluate the correlation between FFR and findings of ischemia obtained by noninvasive methods including stress echocardiography and nuclear medicine and the presence of critical coronary artery obstruction. Methods: Retrospective study of cases treated with systematized and standardized procedures for coronary disease between March 2011 and August 2014. We included 96 patients with 107 critical coronary obstructions (> 50% in the coronary trunk and/or ≥ 70% in other segments) estimated by quantitative coronary angiography (QCA) and intracoronary ultrasound (ICUS). All cases presented ischemia in one of the noninvasive studies. Results: All 96 patients presented ischemia (100%) in one of the functional tests. On FFR study with adenosine 140 g/kg/min, 52% of the cases had values ≤ 0.80. On correlation analysis for FFR ≤ 0.80, the evaluation of sensitivity, specificity, positive and negative predictive values, accuracy, and ROC curve in relation to the stenosis degree and length, and presence of ischemia, no significant values or strong correlation were observed. Conclusion: Coronary FFR using a cut-off value of 0.80 showed no correlation with noninvasive ischemia tests in patients with severe coronary artery obstructions on QCA and ICUS.
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spelling Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow ReserveCoronary Artery Disease / mortalityPercutaneous Coronary InterventionMyocardial IschemiaFractional Flow Reserve, Myocardial / physiologyAbstract Background: Functional assessment of coronary artery obstruction is used in cardiology practice to correlate anatomic obstructions with flow decrease. Among such assessments, the study of the coronary fractional flow reserve (FFR) has become the most widely used. Objective: To evaluate the correlation between FFR and findings of ischemia obtained by noninvasive methods including stress echocardiography and nuclear medicine and the presence of critical coronary artery obstruction. Methods: Retrospective study of cases treated with systematized and standardized procedures for coronary disease between March 2011 and August 2014. We included 96 patients with 107 critical coronary obstructions (> 50% in the coronary trunk and/or ≥ 70% in other segments) estimated by quantitative coronary angiography (QCA) and intracoronary ultrasound (ICUS). All cases presented ischemia in one of the noninvasive studies. Results: All 96 patients presented ischemia (100%) in one of the functional tests. On FFR study with adenosine 140 g/kg/min, 52% of the cases had values ≤ 0.80. On correlation analysis for FFR ≤ 0.80, the evaluation of sensitivity, specificity, positive and negative predictive values, accuracy, and ROC curve in relation to the stenosis degree and length, and presence of ischemia, no significant values or strong correlation were observed. Conclusion: Coronary FFR using a cut-off value of 0.80 showed no correlation with noninvasive ischemia tests in patients with severe coronary artery obstructions on QCA and ICUS.Sociedade Brasileira de Cardiologia - SBC2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000100038Arquivos Brasileiros de Cardiologia v.108 n.1 2017reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20160184info:eu-repo/semantics/openAccessCostantini,Costantino Roberto FrackRamires,Jose AntonioCostantini,Costantino OrtizDenk,Marcos AntonioTarbine,Sergio GustavoSantos,Marcelo de FreitasZanuttini,Daniel AníbalSilveira,Carmen WeigertSouza,Admar Moraes deMacedo,Rafael Michel deeng2017-01-23T00:00:00Zoai:scielo:S0066-782X2017000100038Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2017-01-23T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve
title Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve
spellingShingle Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve
Costantini,Costantino Roberto Frack
Coronary Artery Disease / mortality
Percutaneous Coronary Intervention
Myocardial Ischemia
Fractional Flow Reserve, Myocardial / physiology
title_short Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve
title_full Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve
title_fullStr Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve
title_full_unstemmed Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve
title_sort Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve
author Costantini,Costantino Roberto Frack
author_facet Costantini,Costantino Roberto Frack
Ramires,Jose Antonio
Costantini,Costantino Ortiz
Denk,Marcos Antonio
Tarbine,Sergio Gustavo
Santos,Marcelo de Freitas
Zanuttini,Daniel Aníbal
Silveira,Carmen Weigert
Souza,Admar Moraes de
Macedo,Rafael Michel de
author_role author
author2 Ramires,Jose Antonio
Costantini,Costantino Ortiz
Denk,Marcos Antonio
Tarbine,Sergio Gustavo
Santos,Marcelo de Freitas
Zanuttini,Daniel Aníbal
Silveira,Carmen Weigert
Souza,Admar Moraes de
Macedo,Rafael Michel de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costantini,Costantino Roberto Frack
Ramires,Jose Antonio
Costantini,Costantino Ortiz
Denk,Marcos Antonio
Tarbine,Sergio Gustavo
Santos,Marcelo de Freitas
Zanuttini,Daniel Aníbal
Silveira,Carmen Weigert
Souza,Admar Moraes de
Macedo,Rafael Michel de
dc.subject.por.fl_str_mv Coronary Artery Disease / mortality
Percutaneous Coronary Intervention
Myocardial Ischemia
Fractional Flow Reserve, Myocardial / physiology
topic Coronary Artery Disease / mortality
Percutaneous Coronary Intervention
Myocardial Ischemia
Fractional Flow Reserve, Myocardial / physiology
description Abstract Background: Functional assessment of coronary artery obstruction is used in cardiology practice to correlate anatomic obstructions with flow decrease. Among such assessments, the study of the coronary fractional flow reserve (FFR) has become the most widely used. Objective: To evaluate the correlation between FFR and findings of ischemia obtained by noninvasive methods including stress echocardiography and nuclear medicine and the presence of critical coronary artery obstruction. Methods: Retrospective study of cases treated with systematized and standardized procedures for coronary disease between March 2011 and August 2014. We included 96 patients with 107 critical coronary obstructions (> 50% in the coronary trunk and/or ≥ 70% in other segments) estimated by quantitative coronary angiography (QCA) and intracoronary ultrasound (ICUS). All cases presented ischemia in one of the noninvasive studies. Results: All 96 patients presented ischemia (100%) in one of the functional tests. On FFR study with adenosine 140 g/kg/min, 52% of the cases had values ≤ 0.80. On correlation analysis for FFR ≤ 0.80, the evaluation of sensitivity, specificity, positive and negative predictive values, accuracy, and ROC curve in relation to the stenosis degree and length, and presence of ischemia, no significant values or strong correlation were observed. Conclusion: Coronary FFR using a cut-off value of 0.80 showed no correlation with noninvasive ischemia tests in patients with severe coronary artery obstructions on QCA and ICUS.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000100038
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20160184
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.108 n.1 2017
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
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reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv ||arquivos@cardiol.br
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