Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Journal of Cardiovascular Sciences (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472018000600585 |
Resumo: | Abstract Background: Chagas disease presents in different clinical forms, ranging from asymptomatic to acute, with destruction of heart cells and a possibility of death. In the chronic phase, the parasites can cause serious injuries to different tissues. Objectives: Our objective was to study the effects of physical exercise (swimming) in atrial granules and components of cardiomyocytes in mice with chronic Chagas disease. Methods: In total, 20 male mice were divided into four different groups: untrained control (UC), trained control (TC), untrained infected (UI), and trained infected (TI). In the UI and TI groups, 1,000 forms of Trypanosoma cruzi (Y strain) were inoculated intraperitoneally. After 40 days of infection and proof of chronic phase, the exercise protocol began. The UC and UI groups performed exercise for 10 min/day, and the TC and TI groups followed a training protocol five times a week for 30 minutes during 8 weeks. Ultrathin sections were subjected to morphometric and stereological analyses using electron photomicrographs (x15000) obtained by transmission electron microscopy. Results: The TI group showed the lowest percentage of small granules (58%), while the UI group presented 80% of these granules. The volume density of the Golgi complex and myofibrils in the TI group were reduced compared with those in the UI group, while the parameters of atrial granules and mitochondria increased. Conclusion: Our results suggest that mild physical exercise changes the morphological and morphometric parameters of granules and organelles in the cardiac atrium of mice infected with T. cruzi, and produces moderate beneficial effects on the cardiovascular system. |
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International Journal of Cardiovascular Sciences (Online) |
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Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas DiseaseChagas DiseaseExerciseAtrial Natriuretic FactorMiceAbstract Background: Chagas disease presents in different clinical forms, ranging from asymptomatic to acute, with destruction of heart cells and a possibility of death. In the chronic phase, the parasites can cause serious injuries to different tissues. Objectives: Our objective was to study the effects of physical exercise (swimming) in atrial granules and components of cardiomyocytes in mice with chronic Chagas disease. Methods: In total, 20 male mice were divided into four different groups: untrained control (UC), trained control (TC), untrained infected (UI), and trained infected (TI). In the UI and TI groups, 1,000 forms of Trypanosoma cruzi (Y strain) were inoculated intraperitoneally. After 40 days of infection and proof of chronic phase, the exercise protocol began. The UC and UI groups performed exercise for 10 min/day, and the TC and TI groups followed a training protocol five times a week for 30 minutes during 8 weeks. Ultrathin sections were subjected to morphometric and stereological analyses using electron photomicrographs (x15000) obtained by transmission electron microscopy. Results: The TI group showed the lowest percentage of small granules (58%), while the UI group presented 80% of these granules. The volume density of the Golgi complex and myofibrils in the TI group were reduced compared with those in the UI group, while the parameters of atrial granules and mitochondria increased. Conclusion: Our results suggest that mild physical exercise changes the morphological and morphometric parameters of granules and organelles in the cardiac atrium of mice infected with T. cruzi, and produces moderate beneficial effects on the cardiovascular system.Sociedade Brasileira de Cardiologia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472018000600585International Journal of Cardiovascular Sciences v.31 n.6 2018reponame:International Journal of Cardiovascular Sciences (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/2359-4802.20180060info:eu-repo/semantics/openAccessFerraboli,RobertoOrnelas,Elisabete De MarcoFonseca,Fernando Luiz AffonsoVeiga,Glaucia Luciano daCardoso,Clever GomesMarques,Mara RubiaMaifrino,Laura Beatriz Mesianoeng2018-11-13T00:00:00Zoai:scielo:S2359-56472018000600585Revistahttp://publicacoes.cardiol.br/portal/ijcshttps://old.scielo.br/oai/scielo-oai.phptailanerodrigues@cardiol.br||revistaijcs@cardiol.br2359-56472359-4802opendoar:2018-11-13T00:00International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease |
title |
Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease |
spellingShingle |
Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease Ferraboli,Roberto Chagas Disease Exercise Atrial Natriuretic Factor Mice |
title_short |
Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease |
title_full |
Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease |
title_fullStr |
Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease |
title_full_unstemmed |
Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease |
title_sort |
Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease |
author |
Ferraboli,Roberto |
author_facet |
Ferraboli,Roberto Ornelas,Elisabete De Marco Fonseca,Fernando Luiz Affonso Veiga,Glaucia Luciano da Cardoso,Clever Gomes Marques,Mara Rubia Maifrino,Laura Beatriz Mesiano |
author_role |
author |
author2 |
Ornelas,Elisabete De Marco Fonseca,Fernando Luiz Affonso Veiga,Glaucia Luciano da Cardoso,Clever Gomes Marques,Mara Rubia Maifrino,Laura Beatriz Mesiano |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Ferraboli,Roberto Ornelas,Elisabete De Marco Fonseca,Fernando Luiz Affonso Veiga,Glaucia Luciano da Cardoso,Clever Gomes Marques,Mara Rubia Maifrino,Laura Beatriz Mesiano |
dc.subject.por.fl_str_mv |
Chagas Disease Exercise Atrial Natriuretic Factor Mice |
topic |
Chagas Disease Exercise Atrial Natriuretic Factor Mice |
description |
Abstract Background: Chagas disease presents in different clinical forms, ranging from asymptomatic to acute, with destruction of heart cells and a possibility of death. In the chronic phase, the parasites can cause serious injuries to different tissues. Objectives: Our objective was to study the effects of physical exercise (swimming) in atrial granules and components of cardiomyocytes in mice with chronic Chagas disease. Methods: In total, 20 male mice were divided into four different groups: untrained control (UC), trained control (TC), untrained infected (UI), and trained infected (TI). In the UI and TI groups, 1,000 forms of Trypanosoma cruzi (Y strain) were inoculated intraperitoneally. After 40 days of infection and proof of chronic phase, the exercise protocol began. The UC and UI groups performed exercise for 10 min/day, and the TC and TI groups followed a training protocol five times a week for 30 minutes during 8 weeks. Ultrathin sections were subjected to morphometric and stereological analyses using electron photomicrographs (x15000) obtained by transmission electron microscopy. Results: The TI group showed the lowest percentage of small granules (58%), while the UI group presented 80% of these granules. The volume density of the Golgi complex and myofibrils in the TI group were reduced compared with those in the UI group, while the parameters of atrial granules and mitochondria increased. Conclusion: Our results suggest that mild physical exercise changes the morphological and morphometric parameters of granules and organelles in the cardiac atrium of mice infected with T. cruzi, and produces moderate beneficial effects on the cardiovascular system. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472018000600585 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472018000600585 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/2359-4802.20180060 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
dc.source.none.fl_str_mv |
International Journal of Cardiovascular Sciences v.31 n.6 2018 reponame:International Journal of Cardiovascular Sciences (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
International Journal of Cardiovascular Sciences (Online) |
collection |
International Journal of Cardiovascular Sciences (Online) |
repository.name.fl_str_mv |
International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
tailanerodrigues@cardiol.br||revistaijcs@cardiol.br |
_version_ |
1754732625316020224 |