Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Journal of Cardiovascular Sciences (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000300254 |
Resumo: | Abstract Background: Acute coronary syndrome (ACS) is a cardiovascular disease caused by obstruction of coronary arteries by atheromatous plaque. Susceptibility to this disease may be related to genetic variations, such as single nucleotide polymorphisms (SNPs). Objective: In this study, we evaluated the relationship between SNPs in IL8 (rs4073; -251 A/T) and IL16 (rs11556218; T/G) genes and SCA in a Brazilian population. Materials and Methods: A sample of 200 patients with ACS and 50 non-ACS patients hospitalized at the Real Hospital Português, Recife - PE, Brazil, and 220 blood donors (donors) was used. Genotyping was carried out by polymerase chain reaction, and DNA sequencing. Statistical analyzes were performed using the Williams G, Chi-square and Kruskal Wallis tests, using the BioEstat 5.0 program, and the data with a value of p < 0.05 were considered significant. Results: In the IL8 gene, the AT genotype was the most frequent (p > 0.05) in all three groups. In the IL16 gene, genotypic distributions were different between patients with ACS and the donor group (p = 0.002), with the most frequent G allele in the second group (p = 0.0052). The IL-16 cytokine was higher in donors than in patients with ACS (p = 0.04) and the G (TG + GG) allele had higher values of this cytokine (p = 0.01). Conclusions: The results demonstrate the important role of the rs11556218 SNP in IL16 gene in SCA, evidencing that the G allele may be associated with a decreased risk of the disease. |
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International Journal of Cardiovascular Sciences (Online) |
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Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary SyndromeCardiovascular DiseasesAcute Coronary SyndromeGenotypeDyslipideiaDiabetes MellitusObesitySedentarismAbstract Background: Acute coronary syndrome (ACS) is a cardiovascular disease caused by obstruction of coronary arteries by atheromatous plaque. Susceptibility to this disease may be related to genetic variations, such as single nucleotide polymorphisms (SNPs). Objective: In this study, we evaluated the relationship between SNPs in IL8 (rs4073; -251 A/T) and IL16 (rs11556218; T/G) genes and SCA in a Brazilian population. Materials and Methods: A sample of 200 patients with ACS and 50 non-ACS patients hospitalized at the Real Hospital Português, Recife - PE, Brazil, and 220 blood donors (donors) was used. Genotyping was carried out by polymerase chain reaction, and DNA sequencing. Statistical analyzes were performed using the Williams G, Chi-square and Kruskal Wallis tests, using the BioEstat 5.0 program, and the data with a value of p < 0.05 were considered significant. Results: In the IL8 gene, the AT genotype was the most frequent (p > 0.05) in all three groups. In the IL16 gene, genotypic distributions were different between patients with ACS and the donor group (p = 0.002), with the most frequent G allele in the second group (p = 0.0052). The IL-16 cytokine was higher in donors than in patients with ACS (p = 0.04) and the G (TG + GG) allele had higher values of this cytokine (p = 0.01). Conclusions: The results demonstrate the important role of the rs11556218 SNP in IL16 gene in SCA, evidencing that the G allele may be associated with a decreased risk of the disease.Sociedade Brasileira de Cardiologia2020-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000300254International Journal of Cardiovascular Sciences v.33 n.3 2020reponame:International Journal of Cardiovascular Sciences (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.36660/ijcs.201810080info:eu-repo/semantics/openAccessSilva,Lílian Caroliny AmorimAraújo,Romário MartinsSoares,Fábia Carla SilvaWerkhauser,Roberto PereiraMontenegro,Sergio TavaresTashiro,TetsuoCarvalho,Viviane do Carmo VasconcelosMontenegro,Silvia Maria Lucenaeng2020-05-26T00:00:00Zoai:scielo:S2359-56472020000300254Revistahttp://publicacoes.cardiol.br/portal/ijcshttps://old.scielo.br/oai/scielo-oai.phptailanerodrigues@cardiol.br||revistaijcs@cardiol.br2359-56472359-4802opendoar:2020-05-26T00:00International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome |
title |
Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome |
spellingShingle |
Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome Silva,Lílian Caroliny Amorim Cardiovascular Diseases Acute Coronary Syndrome Genotype Dyslipideia Diabetes Mellitus Obesity Sedentarism |
title_short |
Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome |
title_full |
Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome |
title_fullStr |
Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome |
title_full_unstemmed |
Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome |
title_sort |
Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome |
author |
Silva,Lílian Caroliny Amorim |
author_facet |
Silva,Lílian Caroliny Amorim Araújo,Romário Martins Soares,Fábia Carla Silva Werkhauser,Roberto Pereira Montenegro,Sergio Tavares Tashiro,Tetsuo Carvalho,Viviane do Carmo Vasconcelos Montenegro,Silvia Maria Lucena |
author_role |
author |
author2 |
Araújo,Romário Martins Soares,Fábia Carla Silva Werkhauser,Roberto Pereira Montenegro,Sergio Tavares Tashiro,Tetsuo Carvalho,Viviane do Carmo Vasconcelos Montenegro,Silvia Maria Lucena |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Lílian Caroliny Amorim Araújo,Romário Martins Soares,Fábia Carla Silva Werkhauser,Roberto Pereira Montenegro,Sergio Tavares Tashiro,Tetsuo Carvalho,Viviane do Carmo Vasconcelos Montenegro,Silvia Maria Lucena |
dc.subject.por.fl_str_mv |
Cardiovascular Diseases Acute Coronary Syndrome Genotype Dyslipideia Diabetes Mellitus Obesity Sedentarism |
topic |
Cardiovascular Diseases Acute Coronary Syndrome Genotype Dyslipideia Diabetes Mellitus Obesity Sedentarism |
description |
Abstract Background: Acute coronary syndrome (ACS) is a cardiovascular disease caused by obstruction of coronary arteries by atheromatous plaque. Susceptibility to this disease may be related to genetic variations, such as single nucleotide polymorphisms (SNPs). Objective: In this study, we evaluated the relationship between SNPs in IL8 (rs4073; -251 A/T) and IL16 (rs11556218; T/G) genes and SCA in a Brazilian population. Materials and Methods: A sample of 200 patients with ACS and 50 non-ACS patients hospitalized at the Real Hospital Português, Recife - PE, Brazil, and 220 blood donors (donors) was used. Genotyping was carried out by polymerase chain reaction, and DNA sequencing. Statistical analyzes were performed using the Williams G, Chi-square and Kruskal Wallis tests, using the BioEstat 5.0 program, and the data with a value of p < 0.05 were considered significant. Results: In the IL8 gene, the AT genotype was the most frequent (p > 0.05) in all three groups. In the IL16 gene, genotypic distributions were different between patients with ACS and the donor group (p = 0.002), with the most frequent G allele in the second group (p = 0.0052). The IL-16 cytokine was higher in donors than in patients with ACS (p = 0.04) and the G (TG + GG) allele had higher values of this cytokine (p = 0.01). Conclusions: The results demonstrate the important role of the rs11556218 SNP in IL16 gene in SCA, evidencing that the G allele may be associated with a decreased risk of the disease. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000300254 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000300254 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.36660/ijcs.201810080 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
dc.source.none.fl_str_mv |
International Journal of Cardiovascular Sciences v.33 n.3 2020 reponame:International Journal of Cardiovascular Sciences (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
International Journal of Cardiovascular Sciences (Online) |
collection |
International Journal of Cardiovascular Sciences (Online) |
repository.name.fl_str_mv |
International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
tailanerodrigues@cardiol.br||revistaijcs@cardiol.br |
_version_ |
1754732626532368384 |