Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Cardiovascular Surgery (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382003000300006 |
Resumo: | OBJECTIVE: Inflammatory response and metabolic disturbances in coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and without (OFF-PUMP) have been researched. Apoptosis in ischemic reperfusion and chronic disease models has been shown in recent studies. The objective of this study is to compare the apoptosis intensity detected in cardiac myocytes before and after CABG with and without cardiopulmonary bypass. METHOD: Eighteen patients undergoing elective CABG were divided in two groups: the first group underwent cardiopulmonary bypasses and the second group did not. Auricle myocardial samples were obtained at the beginning and at the end of the surgery. Specimens were examined for apoptosis using the TUNEL method. RESULTS: There was no significant difference between the two groups in the surgical, demographic and postoperative data. The number of grafts was statistically different. There was no significant difference between the numbers of cells undergoing apoptosis in the two groups at the beginning of the procedure. There was no significant difference in the number of cells undergoing apoptosis from the beginning to the end of CABG in the OFF-PUMP group. There was a significant difference between the number of cells undergoing apoptosis at the beginning and the end of the CABG in the CPB group (p<0.01). CONCLUSION: The smaller number of cells undergoing apoptosis in the OFF-PUMP group is in accordance with published data that suggest CPB is capable of promoting cell lesion. Having shown that, another favorable argument can be added to the indication of the CABG without CPB. |
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Brazilian Journal of Cardiovascular Surgery (Online) |
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Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypassApoptosisCardiopulmonary bypassCoronary artery bypass graftingOBJECTIVE: Inflammatory response and metabolic disturbances in coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and without (OFF-PUMP) have been researched. Apoptosis in ischemic reperfusion and chronic disease models has been shown in recent studies. The objective of this study is to compare the apoptosis intensity detected in cardiac myocytes before and after CABG with and without cardiopulmonary bypass. METHOD: Eighteen patients undergoing elective CABG were divided in two groups: the first group underwent cardiopulmonary bypasses and the second group did not. Auricle myocardial samples were obtained at the beginning and at the end of the surgery. Specimens were examined for apoptosis using the TUNEL method. RESULTS: There was no significant difference between the two groups in the surgical, demographic and postoperative data. The number of grafts was statistically different. There was no significant difference between the numbers of cells undergoing apoptosis in the two groups at the beginning of the procedure. There was no significant difference in the number of cells undergoing apoptosis from the beginning to the end of CABG in the OFF-PUMP group. There was a significant difference between the number of cells undergoing apoptosis at the beginning and the end of the CABG in the CPB group (p<0.01). CONCLUSION: The smaller number of cells undergoing apoptosis in the OFF-PUMP group is in accordance with published data that suggest CPB is capable of promoting cell lesion. Having shown that, another favorable argument can be added to the indication of the CABG without CPB.Sociedade Brasileira de Cirurgia Cardiovascular2003-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382003000300006Brazilian Journal of Cardiovascular Surgery v.18 n.3 2003reponame:Brazilian Journal of Cardiovascular Surgery (Online)instname:Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)instacron:SBCCV10.1590/S0102-76382003000300006info:eu-repo/semantics/openAccessGaia,Diego FelipeMoreira,Rafael SavioloArrais,MagalyVinhola,Nivia Cristina TotBuffolo,EnioSmith,Ricardo Luizeng2003-12-22T00:00:00Zoai:scielo:S0102-76382003000300006Revistahttp://www.rbccv.org.br/https://old.scielo.br/oai/scielo-oai.php||rosangela.monteiro@incor.usp.br|| domingo@braile.com.br|| brandau@braile.com.br1678-97410102-7638opendoar:2003-12-22T00:00Brazilian Journal of Cardiovascular Surgery (Online) - Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)false |
dc.title.none.fl_str_mv |
Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass |
title |
Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass |
spellingShingle |
Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass Gaia,Diego Felipe Apoptosis Cardiopulmonary bypass Coronary artery bypass grafting |
title_short |
Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass |
title_full |
Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass |
title_fullStr |
Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass |
title_full_unstemmed |
Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass |
title_sort |
Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass |
author |
Gaia,Diego Felipe |
author_facet |
Gaia,Diego Felipe Moreira,Rafael Saviolo Arrais,Magaly Vinhola,Nivia Cristina Tot Buffolo,Enio Smith,Ricardo Luiz |
author_role |
author |
author2 |
Moreira,Rafael Saviolo Arrais,Magaly Vinhola,Nivia Cristina Tot Buffolo,Enio Smith,Ricardo Luiz |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gaia,Diego Felipe Moreira,Rafael Saviolo Arrais,Magaly Vinhola,Nivia Cristina Tot Buffolo,Enio Smith,Ricardo Luiz |
dc.subject.por.fl_str_mv |
Apoptosis Cardiopulmonary bypass Coronary artery bypass grafting |
topic |
Apoptosis Cardiopulmonary bypass Coronary artery bypass grafting |
description |
OBJECTIVE: Inflammatory response and metabolic disturbances in coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and without (OFF-PUMP) have been researched. Apoptosis in ischemic reperfusion and chronic disease models has been shown in recent studies. The objective of this study is to compare the apoptosis intensity detected in cardiac myocytes before and after CABG with and without cardiopulmonary bypass. METHOD: Eighteen patients undergoing elective CABG were divided in two groups: the first group underwent cardiopulmonary bypasses and the second group did not. Auricle myocardial samples were obtained at the beginning and at the end of the surgery. Specimens were examined for apoptosis using the TUNEL method. RESULTS: There was no significant difference between the two groups in the surgical, demographic and postoperative data. The number of grafts was statistically different. There was no significant difference between the numbers of cells undergoing apoptosis in the two groups at the beginning of the procedure. There was no significant difference in the number of cells undergoing apoptosis from the beginning to the end of CABG in the OFF-PUMP group. There was a significant difference between the number of cells undergoing apoptosis at the beginning and the end of the CABG in the CPB group (p<0.01). CONCLUSION: The smaller number of cells undergoing apoptosis in the OFF-PUMP group is in accordance with published data that suggest CPB is capable of promoting cell lesion. Having shown that, another favorable argument can be added to the indication of the CABG without CPB. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382003000300006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382003000300006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-76382003000300006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cirurgia Cardiovascular |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cirurgia Cardiovascular |
dc.source.none.fl_str_mv |
Brazilian Journal of Cardiovascular Surgery v.18 n.3 2003 reponame:Brazilian Journal of Cardiovascular Surgery (Online) instname:Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV) instacron:SBCCV |
instname_str |
Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV) |
instacron_str |
SBCCV |
institution |
SBCCV |
reponame_str |
Brazilian Journal of Cardiovascular Surgery (Online) |
collection |
Brazilian Journal of Cardiovascular Surgery (Online) |
repository.name.fl_str_mv |
Brazilian Journal of Cardiovascular Surgery (Online) - Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV) |
repository.mail.fl_str_mv |
||rosangela.monteiro@incor.usp.br|| domingo@braile.com.br|| brandau@braile.com.br |
_version_ |
1752126595042115584 |