The behavior of Troponin I and CKMB mass in children who underwent surgical correction of congenital heart malformations

• Autor(a) principal: Salerno,Pedro Rafael
• Data de Publicação: 2003
• Outros Autores: Jatene,Fabio Biscegli, Figueiredo,Patrícia Elias, Bosisio,Ieda Jatene, Jatene,Marcelo Biscegli, Santos,Magaly Arraes dos, Souza,Luís Carlos Bento de, Jatene,Adib Domingos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Cardiovascular Surgery (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382003000300008
• topic: Troponin I/blood; Creatine kinase/blood; Heart defects, congenital/surgery; Magnesium sulfate/therapeutic use; Cardioplegic solutions/chemistry

OBJECTIVE: To analyze the behavior of troponin (TROP I) and CKMB mass (CKMBm) in regards to the addition of magnesium in cardioplegic solutions; and also the influence of per-operative factors. METHOD: A total of 28 children with ages ranging from 3 to 108 months were studied. The mean weight was 11.8 kg. Eighteen were male. The patients were divided into two groups. Sixteen children in group I (GI) and 12 in group II (GII). The patients in GI received cold blood cardioplegic solution with magnesium (12 mEq/L) and potassium chloride (20 mEq/L) at 20 mL/kg. The patients in GII received the same solution without magnesium. Six blood samples were collected for serum analysis of the concentration of TROP I and CKMBm. The blood samples were collected before clamping the aorta and at 1, 6, 24, 48 and 72 hours after aorta clamping termination. RESULTS: There were no statistical differences in the TROP I and CKMBm levels between the two groups. Among the per-operative factors cyanosis influenced the TROP I and CKMBm levels. Additionally, the aorta clamping time influenced the TROP I levels. CONCLUSIONS: The addition of magnesium in the cardioplegic solution was not associated with different levels of TROP I and CKMBm. Cyanosis and aorta clamping time interfered with peak TROP I levels.