SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Food Science and Technology (Campinas) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100730 |
Resumo: | Abstract Accumulating data has indicated that long noncoding RNAs (lncRNAs) play critical roles in multiple cancers including gastric cancer (GC). However, the functional role of SNHG17 in gastric cancer (GC) development and related biological mechanisms remain unknown. In the study, our results demonstrated that SNHG17 expression was higher in tumor tissues compared to adjacent normal tissues in 99 cases of patients with GC. Higher SNHG17 expression positively associated with lymph node metastasis, advanced TNM stage and predicted a worse prognosis in GC patients. Functionally, we showed that overexpression of SNHG17 promoted cell proliferation, cell colony formation and cell invasion in vitro. However, SNHG17 knockdown significantly inhibited cell proliferation and invasion of GC. Furthermore, we demonstrated that SNHG17 promoted cell proliferation and invasion by regulating RUNX3 via interacting with EZH2 in GC cells. In addition, overexpression of SNHG17 reversed the cell proliferation and invasion induced by SNHG17 in GC. Thus, these results indicated that SNHG17 could serve as a prognostic biomarker and target of GC treatment. |
id |
SBCTA-1_01d5a92048a26ee7aa10665fcaf32428 |
---|---|
oai_identifier_str |
oai:scielo:S0101-20612022000100730 |
network_acronym_str |
SBCTA-1 |
network_name_str |
Food Science and Technology (Campinas) |
repository_id_str |
|
spelling |
SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2gastric cancerlong noncoding RNAsSNHG17EZH2RUNX3Abstract Accumulating data has indicated that long noncoding RNAs (lncRNAs) play critical roles in multiple cancers including gastric cancer (GC). However, the functional role of SNHG17 in gastric cancer (GC) development and related biological mechanisms remain unknown. In the study, our results demonstrated that SNHG17 expression was higher in tumor tissues compared to adjacent normal tissues in 99 cases of patients with GC. Higher SNHG17 expression positively associated with lymph node metastasis, advanced TNM stage and predicted a worse prognosis in GC patients. Functionally, we showed that overexpression of SNHG17 promoted cell proliferation, cell colony formation and cell invasion in vitro. However, SNHG17 knockdown significantly inhibited cell proliferation and invasion of GC. Furthermore, we demonstrated that SNHG17 promoted cell proliferation and invasion by regulating RUNX3 via interacting with EZH2 in GC cells. In addition, overexpression of SNHG17 reversed the cell proliferation and invasion induced by SNHG17 in GC. Thus, these results indicated that SNHG17 could serve as a prognostic biomarker and target of GC treatment.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100730Food Science and Technology v.42 2022reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.53521info:eu-repo/semantics/openAccessZHANG,XinmeiFAN,GuofangZHAN,JianghongGUAN,Zihuaeng2022-02-23T00:00:00Zoai:scielo:S0101-20612022000100730Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2022-02-23T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false |
dc.title.none.fl_str_mv |
SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2 |
title |
SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2 |
spellingShingle |
SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2 ZHANG,Xinmei gastric cancer long noncoding RNAs SNHG17 EZH2 RUNX3 |
title_short |
SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2 |
title_full |
SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2 |
title_fullStr |
SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2 |
title_full_unstemmed |
SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2 |
title_sort |
SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2 |
author |
ZHANG,Xinmei |
author_facet |
ZHANG,Xinmei FAN,Guofang ZHAN,Jianghong GUAN,Zihua |
author_role |
author |
author2 |
FAN,Guofang ZHAN,Jianghong GUAN,Zihua |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
ZHANG,Xinmei FAN,Guofang ZHAN,Jianghong GUAN,Zihua |
dc.subject.por.fl_str_mv |
gastric cancer long noncoding RNAs SNHG17 EZH2 RUNX3 |
topic |
gastric cancer long noncoding RNAs SNHG17 EZH2 RUNX3 |
description |
Abstract Accumulating data has indicated that long noncoding RNAs (lncRNAs) play critical roles in multiple cancers including gastric cancer (GC). However, the functional role of SNHG17 in gastric cancer (GC) development and related biological mechanisms remain unknown. In the study, our results demonstrated that SNHG17 expression was higher in tumor tissues compared to adjacent normal tissues in 99 cases of patients with GC. Higher SNHG17 expression positively associated with lymph node metastasis, advanced TNM stage and predicted a worse prognosis in GC patients. Functionally, we showed that overexpression of SNHG17 promoted cell proliferation, cell colony formation and cell invasion in vitro. However, SNHG17 knockdown significantly inhibited cell proliferation and invasion of GC. Furthermore, we demonstrated that SNHG17 promoted cell proliferation and invasion by regulating RUNX3 via interacting with EZH2 in GC cells. In addition, overexpression of SNHG17 reversed the cell proliferation and invasion induced by SNHG17 in GC. Thus, these results indicated that SNHG17 could serve as a prognostic biomarker and target of GC treatment. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100730 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100730 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/fst.53521 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
dc.source.none.fl_str_mv |
Food Science and Technology v.42 2022 reponame:Food Science and Technology (Campinas) instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA |
instname_str |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
instacron_str |
SBCTA |
institution |
SBCTA |
reponame_str |
Food Science and Technology (Campinas) |
collection |
Food Science and Technology (Campinas) |
repository.name.fl_str_mv |
Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
repository.mail.fl_str_mv |
||revista@sbcta.org.br |
_version_ |
1752126332794306560 |