Genetic risk factors for human susceptibility to infections of relevance in dermatology
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962011000400013 |
Resumo: | BACKGROUND: In the pre-microbiological era, it was widely accepted that diseases, today known to be infectious, were hereditary. With the discovery of microorganisms and their role in the pathogenesis of several diseases, it was suggested that exposure to the pathogen was enough to explain infection. Nowadays, it is clear that infection is the result of a complex interplay between pathogen and host, therefore dependant on the genetic make-up of the two organisms. Dermatology offers several examples of infectious diseases in different stages of understanding of their molecular basis. In this review, we summarize the main advances towards dissecting the genetic component controlling human susceptibility to infectious diseases of interest in dermatology. Widely investigated diseases such as leprosy and leishmaniasis are discussed from the genetic perspective of both host and pathogen. Others, such as rare mycobacterioses, fungal infections and syphilis, are presented as good opportunities for research in the field of genetics of infection. |
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Genetic risk factors for human susceptibility to infections of relevance in dermatologyDermatologyInfectionPolymorphism, geneticBACKGROUND: In the pre-microbiological era, it was widely accepted that diseases, today known to be infectious, were hereditary. With the discovery of microorganisms and their role in the pathogenesis of several diseases, it was suggested that exposure to the pathogen was enough to explain infection. Nowadays, it is clear that infection is the result of a complex interplay between pathogen and host, therefore dependant on the genetic make-up of the two organisms. Dermatology offers several examples of infectious diseases in different stages of understanding of their molecular basis. In this review, we summarize the main advances towards dissecting the genetic component controlling human susceptibility to infectious diseases of interest in dermatology. Widely investigated diseases such as leprosy and leishmaniasis are discussed from the genetic perspective of both host and pathogen. Others, such as rare mycobacterioses, fungal infections and syphilis, are presented as good opportunities for research in the field of genetics of infection.Sociedade Brasileira de Dermatologia2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962011000400013Anais Brasileiros de Dermatologia v.86 n.4 2011reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/S0365-05962011000400013info:eu-repo/semantics/openAccessSardinha,José Felipe JardimTarlé,Roberto GomesFava,Vinícius MedeirosFrancio,Angela SchneiderRamos,Geovana BrottoFerreira,Luiz Carlos de LimaSchriefer,Nicolaus Albert BorgesMira,Marcelo TávoraTalhari,Sinésioeng2011-09-27T00:00:00Zoai:scielo:S0365-05962011000400013Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2011-09-27T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
Genetic risk factors for human susceptibility to infections of relevance in dermatology |
title |
Genetic risk factors for human susceptibility to infections of relevance in dermatology |
spellingShingle |
Genetic risk factors for human susceptibility to infections of relevance in dermatology Sardinha,José Felipe Jardim Dermatology Infection Polymorphism, genetic |
title_short |
Genetic risk factors for human susceptibility to infections of relevance in dermatology |
title_full |
Genetic risk factors for human susceptibility to infections of relevance in dermatology |
title_fullStr |
Genetic risk factors for human susceptibility to infections of relevance in dermatology |
title_full_unstemmed |
Genetic risk factors for human susceptibility to infections of relevance in dermatology |
title_sort |
Genetic risk factors for human susceptibility to infections of relevance in dermatology |
author |
Sardinha,José Felipe Jardim |
author_facet |
Sardinha,José Felipe Jardim Tarlé,Roberto Gomes Fava,Vinícius Medeiros Francio,Angela Schneider Ramos,Geovana Brotto Ferreira,Luiz Carlos de Lima Schriefer,Nicolaus Albert Borges Mira,Marcelo Távora Talhari,Sinésio |
author_role |
author |
author2 |
Tarlé,Roberto Gomes Fava,Vinícius Medeiros Francio,Angela Schneider Ramos,Geovana Brotto Ferreira,Luiz Carlos de Lima Schriefer,Nicolaus Albert Borges Mira,Marcelo Távora Talhari,Sinésio |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sardinha,José Felipe Jardim Tarlé,Roberto Gomes Fava,Vinícius Medeiros Francio,Angela Schneider Ramos,Geovana Brotto Ferreira,Luiz Carlos de Lima Schriefer,Nicolaus Albert Borges Mira,Marcelo Távora Talhari,Sinésio |
dc.subject.por.fl_str_mv |
Dermatology Infection Polymorphism, genetic |
topic |
Dermatology Infection Polymorphism, genetic |
description |
BACKGROUND: In the pre-microbiological era, it was widely accepted that diseases, today known to be infectious, were hereditary. With the discovery of microorganisms and their role in the pathogenesis of several diseases, it was suggested that exposure to the pathogen was enough to explain infection. Nowadays, it is clear that infection is the result of a complex interplay between pathogen and host, therefore dependant on the genetic make-up of the two organisms. Dermatology offers several examples of infectious diseases in different stages of understanding of their molecular basis. In this review, we summarize the main advances towards dissecting the genetic component controlling human susceptibility to infectious diseases of interest in dermatology. Widely investigated diseases such as leprosy and leishmaniasis are discussed from the genetic perspective of both host and pathogen. Others, such as rare mycobacterioses, fungal infections and syphilis, are presented as good opportunities for research in the field of genetics of infection. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962011000400013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962011000400013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0365-05962011000400013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.86 n.4 2011 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126417430118400 |