Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects

Detalhes bibliográficos
Autor(a) principal: Machado,Gustavo Uzêda
Data de Publicação: 2019
Outros Autores: Prates,Fernanda Ventin, Machado,Paulo Roberto Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000100002
Resumo: Abstract: Disseminated leishmaniasis is a severe and emerging form of American tegumentary leishmaniasis. Disseminated leishmaniasis is defined by the presence of more than 10 polymorphic cutaneous lesions, distributed over more than two noncontiguous parts of the body. Nasal mucosal involvement is observed in almost half of cases. Disseminated leishmaniasis patients present with a decreased production of Th1 cytokines in the peripheral blood due to the attraction of leishmania- activated T cells to the multiple cutaneous lesions. Disseminated leishmaniasis development is poorly understood and is related to a complex network involving environmental, host immune response, and parasite factors, in which L. braziliensis polymorphism plays an important role. Disseminated leishmaniasis is a challenging disease to cure, presenting a high failure rate of 75% to pentavalent antimony therapy. Despite its importance and severity, this form of American tegumentary leishmaniasis has been poorly studied and documented, deserving greater attention from professionals working in endemic areas.
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spelling Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspectsAmphotericin BLeishmania braziliensisLeishmaniasis, cutaneousAbstract: Disseminated leishmaniasis is a severe and emerging form of American tegumentary leishmaniasis. Disseminated leishmaniasis is defined by the presence of more than 10 polymorphic cutaneous lesions, distributed over more than two noncontiguous parts of the body. Nasal mucosal involvement is observed in almost half of cases. Disseminated leishmaniasis patients present with a decreased production of Th1 cytokines in the peripheral blood due to the attraction of leishmania- activated T cells to the multiple cutaneous lesions. Disseminated leishmaniasis development is poorly understood and is related to a complex network involving environmental, host immune response, and parasite factors, in which L. braziliensis polymorphism plays an important role. Disseminated leishmaniasis is a challenging disease to cure, presenting a high failure rate of 75% to pentavalent antimony therapy. Despite its importance and severity, this form of American tegumentary leishmaniasis has been poorly studied and documented, deserving greater attention from professionals working in endemic areas.Sociedade Brasileira de Dermatologia2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000100002Anais Brasileiros de Dermatologia v.94 n.1 2019reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20198775info:eu-repo/semantics/openAccessMachado,Gustavo UzêdaPrates,Fernanda VentinMachado,Paulo Roberto Limaeng2019-12-18T00:00:00Zoai:scielo:S0365-05962019000100002Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2019-12-18T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects
title Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects
spellingShingle Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects
Machado,Gustavo Uzêda
Amphotericin B
Leishmania braziliensis
Leishmaniasis, cutaneous
title_short Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects
title_full Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects
title_fullStr Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects
title_full_unstemmed Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects
title_sort Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects
author Machado,Gustavo Uzêda
author_facet Machado,Gustavo Uzêda
Prates,Fernanda Ventin
Machado,Paulo Roberto Lima
author_role author
author2 Prates,Fernanda Ventin
Machado,Paulo Roberto Lima
author2_role author
author
dc.contributor.author.fl_str_mv Machado,Gustavo Uzêda
Prates,Fernanda Ventin
Machado,Paulo Roberto Lima
dc.subject.por.fl_str_mv Amphotericin B
Leishmania braziliensis
Leishmaniasis, cutaneous
topic Amphotericin B
Leishmania braziliensis
Leishmaniasis, cutaneous
description Abstract: Disseminated leishmaniasis is a severe and emerging form of American tegumentary leishmaniasis. Disseminated leishmaniasis is defined by the presence of more than 10 polymorphic cutaneous lesions, distributed over more than two noncontiguous parts of the body. Nasal mucosal involvement is observed in almost half of cases. Disseminated leishmaniasis patients present with a decreased production of Th1 cytokines in the peripheral blood due to the attraction of leishmania- activated T cells to the multiple cutaneous lesions. Disseminated leishmaniasis development is poorly understood and is related to a complex network involving environmental, host immune response, and parasite factors, in which L. braziliensis polymorphism plays an important role. Disseminated leishmaniasis is a challenging disease to cure, presenting a high failure rate of 75% to pentavalent antimony therapy. Despite its importance and severity, this form of American tegumentary leishmaniasis has been poorly studied and documented, deserving greater attention from professionals working in endemic areas.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000100002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000100002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20198775
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.94 n.1 2019
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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