Skin barrier in atopic dermatitis: beyond filaggrin

Detalhes bibliográficos
Autor(a) principal: Zaniboni,Mariana Colombini
Data de Publicação: 2016
Outros Autores: Samorano,Luciana Paula, Orfali,Raquel Leão, Aoki,Valéria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000400472
Resumo: Abstract: Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical trauma. Main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ) and components of the innate immune system. Recent data involving skin barrier reveal new information regarding its structure and its role in the mechanic-immunological defense; atopic dermatitis (AD) is an example of a disease related to dysfunctions associated with this complex.
id SBD-1_e0e942b994931c8ec41e840ff8716ecd
oai_identifier_str oai:scielo:S0365-05962016000400472
network_acronym_str SBD-1
network_name_str Anais brasileiros de dermatologia (Online)
repository_id_str
spelling Skin barrier in atopic dermatitis: beyond filaggrinAntimicrobial cationic peptidesClaudinsDermatitis, atopicImmunity, innateAbstract: Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical trauma. Main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ) and components of the innate immune system. Recent data involving skin barrier reveal new information regarding its structure and its role in the mechanic-immunological defense; atopic dermatitis (AD) is an example of a disease related to dysfunctions associated with this complex.Sociedade Brasileira de Dermatologia2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000400472Anais Brasileiros de Dermatologia v.91 n.4 2016reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20164412info:eu-repo/semantics/openAccessZaniboni,Mariana ColombiniSamorano,Luciana PaulaOrfali,Raquel LeãoAoki,Valériaeng2016-08-26T00:00:00Zoai:scielo:S0365-05962016000400472Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2016-08-26T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Skin barrier in atopic dermatitis: beyond filaggrin
title Skin barrier in atopic dermatitis: beyond filaggrin
spellingShingle Skin barrier in atopic dermatitis: beyond filaggrin
Zaniboni,Mariana Colombini
Antimicrobial cationic peptides
Claudins
Dermatitis, atopic
Immunity, innate
title_short Skin barrier in atopic dermatitis: beyond filaggrin
title_full Skin barrier in atopic dermatitis: beyond filaggrin
title_fullStr Skin barrier in atopic dermatitis: beyond filaggrin
title_full_unstemmed Skin barrier in atopic dermatitis: beyond filaggrin
title_sort Skin barrier in atopic dermatitis: beyond filaggrin
author Zaniboni,Mariana Colombini
author_facet Zaniboni,Mariana Colombini
Samorano,Luciana Paula
Orfali,Raquel Leão
Aoki,Valéria
author_role author
author2 Samorano,Luciana Paula
Orfali,Raquel Leão
Aoki,Valéria
author2_role author
author
author
dc.contributor.author.fl_str_mv Zaniboni,Mariana Colombini
Samorano,Luciana Paula
Orfali,Raquel Leão
Aoki,Valéria
dc.subject.por.fl_str_mv Antimicrobial cationic peptides
Claudins
Dermatitis, atopic
Immunity, innate
topic Antimicrobial cationic peptides
Claudins
Dermatitis, atopic
Immunity, innate
description Abstract: Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical trauma. Main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ) and components of the innate immune system. Recent data involving skin barrier reveal new information regarding its structure and its role in the mechanic-immunological defense; atopic dermatitis (AD) is an example of a disease related to dysfunctions associated with this complex.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000400472
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000400472
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20164412
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.91 n.4 2016
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
_version_ 1752126421098037248

Registros relacionados