Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000200245 |
Resumo: | BACKGROUND: Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain. OBJECTIVE: The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. METHOD: Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis. RESULTS: The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them. A cutoff point of 3 cells/square inch was established to differentiate pityriasis alba from atopic dermatitis, with 80% sensibility and 90% specificity. CONCLUSION: We believe that pityriasis alba and atopic dermatitis should be considered different clinical forms within the spectrum of atopic disease, in which sun radiation plays an important role by modulating the progression of the disease. |
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Anais brasileiros de dermatologia (Online) |
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Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesionsDermatitis, atopicFactor XIIIaPityriasis BACKGROUND: Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain. OBJECTIVE: The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. METHOD: Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis. RESULTS: The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them. A cutoff point of 3 cells/square inch was established to differentiate pityriasis alba from atopic dermatitis, with 80% sensibility and 90% specificity. CONCLUSION: We believe that pityriasis alba and atopic dermatitis should be considered different clinical forms within the spectrum of atopic disease, in which sun radiation plays an important role by modulating the progression of the disease. Sociedade Brasileira de Dermatologia2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000200245Anais Brasileiros de Dermatologia v.89 n.2 2014reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20142201info:eu-repo/semantics/openAccessCarneiro,Francisca Regina OliveiraAmaral,Gabriela Borborema doMendes,Maiana DarwichQuaresma,Juarez Antônio Simõeseng2014-06-11T00:00:00Zoai:scielo:S0365-05962014000200245Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2014-06-11T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions |
title |
Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions |
spellingShingle |
Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions Carneiro,Francisca Regina Oliveira Dermatitis, atopic Factor XIIIa Pityriasis |
title_short |
Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions |
title_full |
Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions |
title_fullStr |
Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions |
title_full_unstemmed |
Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions |
title_sort |
Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions |
author |
Carneiro,Francisca Regina Oliveira |
author_facet |
Carneiro,Francisca Regina Oliveira Amaral,Gabriela Borborema do Mendes,Maiana Darwich Quaresma,Juarez Antônio Simões |
author_role |
author |
author2 |
Amaral,Gabriela Borborema do Mendes,Maiana Darwich Quaresma,Juarez Antônio Simões |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Carneiro,Francisca Regina Oliveira Amaral,Gabriela Borborema do Mendes,Maiana Darwich Quaresma,Juarez Antônio Simões |
dc.subject.por.fl_str_mv |
Dermatitis, atopic Factor XIIIa Pityriasis |
topic |
Dermatitis, atopic Factor XIIIa Pityriasis |
description |
BACKGROUND: Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain. OBJECTIVE: The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. METHOD: Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis. RESULTS: The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them. A cutoff point of 3 cells/square inch was established to differentiate pityriasis alba from atopic dermatitis, with 80% sensibility and 90% specificity. CONCLUSION: We believe that pityriasis alba and atopic dermatitis should be considered different clinical forms within the spectrum of atopic disease, in which sun radiation plays an important role by modulating the progression of the disease. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000200245 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000200245 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/abd1806-4841.20142201 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.89 n.2 2014 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126419486375936 |