Effects of chitosan on healing and strength of colonic anastomosis in rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007 |
Resumo: | PURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing. |
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Acta Cirúrgica Brasileira (Online) |
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Effects of chitosan on healing and strength of colonic anastomosis in ratsChitosanAnastomosis, SurgicalTensile StrengthWound HealingRatsPURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007Acta Cirúrgica Brasileira v.27 n.10 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012001000007info:eu-repo/semantics/openAccessCitgez,BulentCengiz,Ahmet NurettinAkgun,IsmailUludag,MehmetYetkin,GurkanBahat,NeslihanOzcan,OmerPolat,NedimAkcakaya,AdemKaratepe,Oguzhaneng2012-09-27T00:00:00Zoai:scielo:S0102-86502012001000007Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-09-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Effects of chitosan on healing and strength of colonic anastomosis in rats |
title |
Effects of chitosan on healing and strength of colonic anastomosis in rats |
spellingShingle |
Effects of chitosan on healing and strength of colonic anastomosis in rats Citgez,Bulent Chitosan Anastomosis, Surgical Tensile Strength Wound Healing Rats |
title_short |
Effects of chitosan on healing and strength of colonic anastomosis in rats |
title_full |
Effects of chitosan on healing and strength of colonic anastomosis in rats |
title_fullStr |
Effects of chitosan on healing and strength of colonic anastomosis in rats |
title_full_unstemmed |
Effects of chitosan on healing and strength of colonic anastomosis in rats |
title_sort |
Effects of chitosan on healing and strength of colonic anastomosis in rats |
author |
Citgez,Bulent |
author_facet |
Citgez,Bulent Cengiz,Ahmet Nurettin Akgun,Ismail Uludag,Mehmet Yetkin,Gurkan Bahat,Neslihan Ozcan,Omer Polat,Nedim Akcakaya,Adem Karatepe,Oguzhan |
author_role |
author |
author2 |
Cengiz,Ahmet Nurettin Akgun,Ismail Uludag,Mehmet Yetkin,Gurkan Bahat,Neslihan Ozcan,Omer Polat,Nedim Akcakaya,Adem Karatepe,Oguzhan |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Citgez,Bulent Cengiz,Ahmet Nurettin Akgun,Ismail Uludag,Mehmet Yetkin,Gurkan Bahat,Neslihan Ozcan,Omer Polat,Nedim Akcakaya,Adem Karatepe,Oguzhan |
dc.subject.por.fl_str_mv |
Chitosan Anastomosis, Surgical Tensile Strength Wound Healing Rats |
topic |
Chitosan Anastomosis, Surgical Tensile Strength Wound Healing Rats |
description |
PURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502012001000007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.27 n.10 2012 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126441343942656 |