Non-cancerous prognostic factors of hepatocellular carcinoma after liver transplantation

• Autor(a) principal: Batista,Thales Paulo
• Data de Publicação: 2012
• Outros Autores: Miranda,Luiz Eduardo Correia, Sabat,Bernardo David, Melo,Paulo Sérgio Vieira de, Fonseca Neto,Olival Cirilo Lucena da, Amorim,Américo Gusmão, Lacerda,Cláudio Moura
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000600007
• topic: Organ Transplantation; Liver Neoplasms; Carcinoma, Hepatocellular; Survival Analysis; Prognosis

PURPOSE: To explore non-cancerous factors that may be related with medium-term survival (24 months) after liver transplantation (LT) in this data from northeast Brazil. METHODS: A cross-sectional study was carried out in patients who underwent deceased-donor orthotopic LT because hepatocellular carcinoma (HCC) at the University of Pernambuco, Brazil. Non-cancerous factors (i.e.: donor-, receptor-, surgery- and center-related variables) were explored as prognostic factors of medium-term survival using univariate and multivariate approachs. RESULTS: Sixty-one patients were included for analysis. Their three, six, 12 and 24-month overall cumulative survivals were 88.5%, 80.3%, 73.8% and 65.6%, respectively. Our univariate analysis identified red blood cell transfusion (Exp[b]=1.26; p<0.01) and hepato-venous reconstruction technique (84.6% vs. 51.4%, p<0.01; respectively for piggyback and conventional approaches) as significantly related to post-LT survival. The multivariate analysis confirmed the hepato-venous reconstruction technique was an independent prognostic factor. CONCLUSION: The piggyback technique was related to improved medium-term survival of hepatocellular carcinoma patients after liver transplantation in this northeast Brazilian sample.