Expression of stromal elements of prostatic adenocarcinoma in different gleason scores

Detalhes bibliográficos
Autor(a) principal: Osorio,Clarice Fraga Esteves Maciel
Data de Publicação: 2019
Outros Autores: Costa,Waldemar Silva, Gallo,Carla Braga Mano, Sampaio,Francisco José Barcellos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001000214
Resumo: Abstract Purpose: To quantify and compare the expression of stromal elements in prostate adenocarcinoma of different Gleason scores with non-tumor area (control). Methods: We obtained 132 specimens from samples of prostate peripheral and transition zone. We analyzed the following elements of the extracellular matrix: collagen fibers, elastic system, smooth muscle fibers and blood vessels. The tumor area and non-tumor area (control) of the TMA (tissue microarray) were photographed and analyzed using the ImageJ software. Results: The comparison between the tumor area and the non-tumor area showed significant differences between stromal prostate elements. There was an increase of collagen fibers in the tumor area, mainly in Gleason 7. Elastic system fibers showed similar result, also from the Gleason 7. Blood vessels showed a significant increase occurred in all analyzed groups. The muscle fibers exhibited a different behavior, with a decrease in relation to the tumor area. Conclusions: There is a significant difference between the extracellular matrix in prostate cancer compared to the non-tumor area (control) especially in Gleason 7. Important modifications of the prostatic stromal elements strongly correlate with different Gleason scores and can contribute to predict the pathological staging of prostate cancer.
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spelling Expression of stromal elements of prostatic adenocarcinoma in different gleason scoresProstatic NeoplasmsNeoplasm GradingStromal CellsHistologyAbstract Purpose: To quantify and compare the expression of stromal elements in prostate adenocarcinoma of different Gleason scores with non-tumor area (control). Methods: We obtained 132 specimens from samples of prostate peripheral and transition zone. We analyzed the following elements of the extracellular matrix: collagen fibers, elastic system, smooth muscle fibers and blood vessels. The tumor area and non-tumor area (control) of the TMA (tissue microarray) were photographed and analyzed using the ImageJ software. Results: The comparison between the tumor area and the non-tumor area showed significant differences between stromal prostate elements. There was an increase of collagen fibers in the tumor area, mainly in Gleason 7. Elastic system fibers showed similar result, also from the Gleason 7. Blood vessels showed a significant increase occurred in all analyzed groups. The muscle fibers exhibited a different behavior, with a decrease in relation to the tumor area. Conclusions: There is a significant difference between the extracellular matrix in prostate cancer compared to the non-tumor area (control) especially in Gleason 7. Important modifications of the prostatic stromal elements strongly correlate with different Gleason scores and can contribute to predict the pathological staging of prostate cancer.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2019-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001000214Acta Cirúrgica Brasileira v.34 n.10 2019reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020190100000005info:eu-repo/semantics/openAccessOsorio,Clarice Fraga Esteves MacielCosta,Waldemar SilvaGallo,Carla Braga ManoSampaio,Francisco José Barcelloseng2019-12-10T00:00:00Zoai:scielo:S0102-86502019001000214Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2019-12-10T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Expression of stromal elements of prostatic adenocarcinoma in different gleason scores
title Expression of stromal elements of prostatic adenocarcinoma in different gleason scores
spellingShingle Expression of stromal elements of prostatic adenocarcinoma in different gleason scores
Osorio,Clarice Fraga Esteves Maciel
Prostatic Neoplasms
Neoplasm Grading
Stromal Cells
Histology
title_short Expression of stromal elements of prostatic adenocarcinoma in different gleason scores
title_full Expression of stromal elements of prostatic adenocarcinoma in different gleason scores
title_fullStr Expression of stromal elements of prostatic adenocarcinoma in different gleason scores
title_full_unstemmed Expression of stromal elements of prostatic adenocarcinoma in different gleason scores
title_sort Expression of stromal elements of prostatic adenocarcinoma in different gleason scores
author Osorio,Clarice Fraga Esteves Maciel
author_facet Osorio,Clarice Fraga Esteves Maciel
Costa,Waldemar Silva
Gallo,Carla Braga Mano
Sampaio,Francisco José Barcellos
author_role author
author2 Costa,Waldemar Silva
Gallo,Carla Braga Mano
Sampaio,Francisco José Barcellos
author2_role author
author
author
dc.contributor.author.fl_str_mv Osorio,Clarice Fraga Esteves Maciel
Costa,Waldemar Silva
Gallo,Carla Braga Mano
Sampaio,Francisco José Barcellos
dc.subject.por.fl_str_mv Prostatic Neoplasms
Neoplasm Grading
Stromal Cells
Histology
topic Prostatic Neoplasms
Neoplasm Grading
Stromal Cells
Histology
description Abstract Purpose: To quantify and compare the expression of stromal elements in prostate adenocarcinoma of different Gleason scores with non-tumor area (control). Methods: We obtained 132 specimens from samples of prostate peripheral and transition zone. We analyzed the following elements of the extracellular matrix: collagen fibers, elastic system, smooth muscle fibers and blood vessels. The tumor area and non-tumor area (control) of the TMA (tissue microarray) were photographed and analyzed using the ImageJ software. Results: The comparison between the tumor area and the non-tumor area showed significant differences between stromal prostate elements. There was an increase of collagen fibers in the tumor area, mainly in Gleason 7. Elastic system fibers showed similar result, also from the Gleason 7. Blood vessels showed a significant increase occurred in all analyzed groups. The muscle fibers exhibited a different behavior, with a decrease in relation to the tumor area. Conclusions: There is a significant difference between the extracellular matrix in prostate cancer compared to the non-tumor area (control) especially in Gleason 7. Important modifications of the prostatic stromal elements strongly correlate with different Gleason scores and can contribute to predict the pathological staging of prostate cancer.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001000214
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020190100000005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.34 n.10 2019
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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