Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006001000002 |
Resumo: | PURPOSE: To investigate the effect of oral glutamine alone or combined with short chain fatty acids (SCFA) in the intestinal adaptation of rats submitted to an massive enterectomy. METHODS: After receiving 70% small bowel resection, 30 Wistar rats were randomized to received either standard rat chow (control group, n=10) or the same diet supplemented with 3,05% of glutamine alone (glutamine group, n=10) or combined with a solution containing SCFA (glutamine+SCFA group, n=10). Animals were killed on the 14th postoperative day. Mucosal weight, crypt depth, villus height, wall width, and the mucosal content of DNA, were assessed in basal conditions (resected gut specimen) and compared to the small bowel specimen collected on the postoperative day 14, at both jejunum and ileum sites. RESULTS: All groups presented similar pattern in weight evolution. In all groups, both the morphological findings and the DNA content were significantly higher at the end of the experiment than in basal conditions, at both the jejunum and ileum. Except for the jejunum wall width that was higher in control group (808±95 µ) than in the other two groups (glutamine = 649±88 µ and glutamine+SCFA = 656±92; p<0.01), there was no difference among them in all variables at both intestinal sites after 14 days. CONCLUSION: All groups presented adaptation of the intestinal mucosa in the remnant gut. Glutamine combined or not with short chain fatty acids fails to influence the adaptive response of the small bowel. |
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Acta Cirúrgica Brasileira (Online) |
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Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in ratsGlutamineFatty acidsButyratesIntestinal MucosaIntestine, smallNutritionPURPOSE: To investigate the effect of oral glutamine alone or combined with short chain fatty acids (SCFA) in the intestinal adaptation of rats submitted to an massive enterectomy. METHODS: After receiving 70% small bowel resection, 30 Wistar rats were randomized to received either standard rat chow (control group, n=10) or the same diet supplemented with 3,05% of glutamine alone (glutamine group, n=10) or combined with a solution containing SCFA (glutamine+SCFA group, n=10). Animals were killed on the 14th postoperative day. Mucosal weight, crypt depth, villus height, wall width, and the mucosal content of DNA, were assessed in basal conditions (resected gut specimen) and compared to the small bowel specimen collected on the postoperative day 14, at both jejunum and ileum sites. RESULTS: All groups presented similar pattern in weight evolution. In all groups, both the morphological findings and the DNA content were significantly higher at the end of the experiment than in basal conditions, at both the jejunum and ileum. Except for the jejunum wall width that was higher in control group (808±95 µ) than in the other two groups (glutamine = 649±88 µ and glutamine+SCFA = 656±92; p<0.01), there was no difference among them in all variables at both intestinal sites after 14 days. CONCLUSION: All groups presented adaptation of the intestinal mucosa in the remnant gut. Glutamine combined or not with short chain fatty acids fails to influence the adaptive response of the small bowel.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2006-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006001000002Acta Cirúrgica Brasileira v.21 suppl.4 2006reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502006001000002info:eu-repo/semantics/openAccessNeves,José de SouzaAguilar-Nascimento,José Eduardo deGomes-da-Silva,Maria Helena GaivaCavalcanti,Rosecélia NunesBicudo,Alberto SalomãoNascimento,MarianaNochi Jr.,Rubens Jardimeng2007-02-07T00:00:00Zoai:scielo:S0102-86502006001000002Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2007-02-07T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats |
title |
Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats |
spellingShingle |
Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats Neves,José de Souza Glutamine Fatty acids Butyrates Intestinal Mucosa Intestine, small Nutrition |
title_short |
Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats |
title_full |
Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats |
title_fullStr |
Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats |
title_full_unstemmed |
Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats |
title_sort |
Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats |
author |
Neves,José de Souza |
author_facet |
Neves,José de Souza Aguilar-Nascimento,José Eduardo de Gomes-da-Silva,Maria Helena Gaiva Cavalcanti,Rosecélia Nunes Bicudo,Alberto Salomão Nascimento,Mariana Nochi Jr.,Rubens Jardim |
author_role |
author |
author2 |
Aguilar-Nascimento,José Eduardo de Gomes-da-Silva,Maria Helena Gaiva Cavalcanti,Rosecélia Nunes Bicudo,Alberto Salomão Nascimento,Mariana Nochi Jr.,Rubens Jardim |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Neves,José de Souza Aguilar-Nascimento,José Eduardo de Gomes-da-Silva,Maria Helena Gaiva Cavalcanti,Rosecélia Nunes Bicudo,Alberto Salomão Nascimento,Mariana Nochi Jr.,Rubens Jardim |
dc.subject.por.fl_str_mv |
Glutamine Fatty acids Butyrates Intestinal Mucosa Intestine, small Nutrition |
topic |
Glutamine Fatty acids Butyrates Intestinal Mucosa Intestine, small Nutrition |
description |
PURPOSE: To investigate the effect of oral glutamine alone or combined with short chain fatty acids (SCFA) in the intestinal adaptation of rats submitted to an massive enterectomy. METHODS: After receiving 70% small bowel resection, 30 Wistar rats were randomized to received either standard rat chow (control group, n=10) or the same diet supplemented with 3,05% of glutamine alone (glutamine group, n=10) or combined with a solution containing SCFA (glutamine+SCFA group, n=10). Animals were killed on the 14th postoperative day. Mucosal weight, crypt depth, villus height, wall width, and the mucosal content of DNA, were assessed in basal conditions (resected gut specimen) and compared to the small bowel specimen collected on the postoperative day 14, at both jejunum and ileum sites. RESULTS: All groups presented similar pattern in weight evolution. In all groups, both the morphological findings and the DNA content were significantly higher at the end of the experiment than in basal conditions, at both the jejunum and ileum. Except for the jejunum wall width that was higher in control group (808±95 µ) than in the other two groups (glutamine = 649±88 µ and glutamine+SCFA = 656±92; p<0.01), there was no difference among them in all variables at both intestinal sites after 14 days. CONCLUSION: All groups presented adaptation of the intestinal mucosa in the remnant gut. Glutamine combined or not with short chain fatty acids fails to influence the adaptive response of the small bowel. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006001000002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006001000002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502006001000002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.21 suppl.4 2006 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
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1752126438555779072 |