Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism

Detalhes bibliográficos
Autor(a) principal: Cerqueira,Nereide Freire
Data de Publicação: 2005
Outros Autores: Yoshida,Winston Bonetti, Müller,Sérgio Swain, Sequeira,Júlio Lopes, Rodrigues,Antônio de Castro, Padovani,Carlos Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000300004
Resumo: PURPOSE: To assess the influence of experimental chronic alcoholism in the morphology and biomechanics of the aorta, in a rat model. METHODS: Forty-four Wistar rats were randomly divided into two groups of 22 animals each: in the alcoholism group, the rats received water mixed to increasing concentrations of ethyl alcohol; and control group: the rats received pure water for 180 days. The animals were then killed by an overdose of pentobarbital and the abdominal aortas were excised for histological (hematoxylin-eosin, Masson, Calleja, and Picrosirius red stain), histomorphometrical, and biomechanical analysis. RESULTS: Histology and histomorphometry did not show differences in aorta morphology of both groups. Biomechanical analysis showed a significantly greater yield point elongation in the alcoholic rat group (p<0.05). CONCLUSION: Chronic alcoholism did not cause morphological alterations in the aortic wall but increased elongation, without modifying any other mechanical properties.
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spelling Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholismAlcoholismEthanolAortaElasticityPURPOSE: To assess the influence of experimental chronic alcoholism in the morphology and biomechanics of the aorta, in a rat model. METHODS: Forty-four Wistar rats were randomly divided into two groups of 22 animals each: in the alcoholism group, the rats received water mixed to increasing concentrations of ethyl alcohol; and control group: the rats received pure water for 180 days. The animals were then killed by an overdose of pentobarbital and the abdominal aortas were excised for histological (hematoxylin-eosin, Masson, Calleja, and Picrosirius red stain), histomorphometrical, and biomechanical analysis. RESULTS: Histology and histomorphometry did not show differences in aorta morphology of both groups. Biomechanical analysis showed a significantly greater yield point elongation in the alcoholic rat group (p<0.05). CONCLUSION: Chronic alcoholism did not cause morphological alterations in the aortic wall but increased elongation, without modifying any other mechanical properties.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000300004Acta Cirúrgica Brasileira v.20 n.3 2005reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502005000300004info:eu-repo/semantics/openAccessCerqueira,Nereide FreireYoshida,Winston BonettiMüller,Sérgio SwainSequeira,Júlio LopesRodrigues,Antônio de CastroPadovani,Carlos Robertoeng2005-06-16T00:00:00Zoai:scielo:S0102-86502005000300004Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2005-06-16T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism
title Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism
spellingShingle Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism
Cerqueira,Nereide Freire
Alcoholism
Ethanol
Aorta
Elasticity
title_short Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism
title_full Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism
title_fullStr Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism
title_full_unstemmed Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism
title_sort Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism
author Cerqueira,Nereide Freire
author_facet Cerqueira,Nereide Freire
Yoshida,Winston Bonetti
Müller,Sérgio Swain
Sequeira,Júlio Lopes
Rodrigues,Antônio de Castro
Padovani,Carlos Roberto
author_role author
author2 Yoshida,Winston Bonetti
Müller,Sérgio Swain
Sequeira,Júlio Lopes
Rodrigues,Antônio de Castro
Padovani,Carlos Roberto
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cerqueira,Nereide Freire
Yoshida,Winston Bonetti
Müller,Sérgio Swain
Sequeira,Júlio Lopes
Rodrigues,Antônio de Castro
Padovani,Carlos Roberto
dc.subject.por.fl_str_mv Alcoholism
Ethanol
Aorta
Elasticity
topic Alcoholism
Ethanol
Aorta
Elasticity
description PURPOSE: To assess the influence of experimental chronic alcoholism in the morphology and biomechanics of the aorta, in a rat model. METHODS: Forty-four Wistar rats were randomly divided into two groups of 22 animals each: in the alcoholism group, the rats received water mixed to increasing concentrations of ethyl alcohol; and control group: the rats received pure water for 180 days. The animals were then killed by an overdose of pentobarbital and the abdominal aortas were excised for histological (hematoxylin-eosin, Masson, Calleja, and Picrosirius red stain), histomorphometrical, and biomechanical analysis. RESULTS: Histology and histomorphometry did not show differences in aorta morphology of both groups. Biomechanical analysis showed a significantly greater yield point elongation in the alcoholic rat group (p<0.05). CONCLUSION: Chronic alcoholism did not cause morphological alterations in the aortic wall but increased elongation, without modifying any other mechanical properties.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000300004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000300004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502005000300004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.20 n.3 2005
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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