AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOS
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000100006 |
Resumo: | The effect of the diclofenac sodium (DS) on the healing of anastomosis carried- out in the ileum of rats was studied. Five- hundred and nineteen Wistar rats were randomly assigned to the 4 experimental groups: Group I included 52 rats treated with 3 mg/kg/day of saline, administered intramusculary during 4 days, group II included 110 rats submitted to ileal anastomosis and treated with saline as described previously, group III included 52 rats treated with DS in a dose of 3 mg/kg/day, administered IM during 4 days, and group IV included 295 rats submitted to ileal anastomosis and treated with DS as prior described. In all rats from the 4 experimental groups clinical parameters and measurements of tensile strength, tissue collagen and histological analyses were documented at 4, 7, 14, and 21 postoperative days. There are no clinical alterations in group I rats all over the study. Diarrhoea was observed in 8 rats (15,4%) from group III. In this group both tensile strenght and tissue collagen were descrease when compared with group I rats. Mortality in DS treated rats submitted to ileal anastomosis was higher than those of control groups. In group IV we also observed reard in the healing, with intense PMN inflamatory response, decrease of macrophages and of tissue collagen, and mucosae regeneration. We concluded that DS is deleterious on the healing of anastomosis performed in the ileum of rats |
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AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOSDiclofenaco de SódioAnastomose CirúrgicaIntestino DelgadoThe effect of the diclofenac sodium (DS) on the healing of anastomosis carried- out in the ileum of rats was studied. Five- hundred and nineteen Wistar rats were randomly assigned to the 4 experimental groups: Group I included 52 rats treated with 3 mg/kg/day of saline, administered intramusculary during 4 days, group II included 110 rats submitted to ileal anastomosis and treated with saline as described previously, group III included 52 rats treated with DS in a dose of 3 mg/kg/day, administered IM during 4 days, and group IV included 295 rats submitted to ileal anastomosis and treated with DS as prior described. In all rats from the 4 experimental groups clinical parameters and measurements of tensile strength, tissue collagen and histological analyses were documented at 4, 7, 14, and 21 postoperative days. There are no clinical alterations in group I rats all over the study. Diarrhoea was observed in 8 rats (15,4%) from group III. In this group both tensile strenght and tissue collagen were descrease when compared with group I rats. Mortality in DS treated rats submitted to ileal anastomosis was higher than those of control groups. In group IV we also observed reard in the healing, with intense PMN inflamatory response, decrease of macrophages and of tissue collagen, and mucosae regeneration. We concluded that DS is deleterious on the healing of anastomosis performed in the ileum of ratsSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia1998-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000100006Acta Cirúrgica Brasileira v.13 n.1 1998reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86501998000100006info:eu-repo/semantics/openAccessMinossi,José GuilhermeLeite,Celso Vieira de SouzaNaresse,Luiz EduardoRodrigues,Maria Aparecida M.Curi,Paulo RobertoKobayasi,Shoitieng1998-11-18T00:00:00Zoai:scielo:S0102-86501998000100006Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:1998-11-18T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOS |
title |
AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOS |
spellingShingle |
AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOS Minossi,José Guilherme Diclofenaco de Sódio Anastomose Cirúrgica Intestino Delgado |
title_short |
AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOS |
title_full |
AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOS |
title_fullStr |
AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOS |
title_full_unstemmed |
AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOS |
title_sort |
AÇÃO DO DICLOFENACO DE SÓDIO EM ANASTOMOSES REALIZADAS NO INTESTINO DELGADO DE RATOS |
author |
Minossi,José Guilherme |
author_facet |
Minossi,José Guilherme Leite,Celso Vieira de Souza Naresse,Luiz Eduardo Rodrigues,Maria Aparecida M. Curi,Paulo Roberto Kobayasi,Shoiti |
author_role |
author |
author2 |
Leite,Celso Vieira de Souza Naresse,Luiz Eduardo Rodrigues,Maria Aparecida M. Curi,Paulo Roberto Kobayasi,Shoiti |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Minossi,José Guilherme Leite,Celso Vieira de Souza Naresse,Luiz Eduardo Rodrigues,Maria Aparecida M. Curi,Paulo Roberto Kobayasi,Shoiti |
dc.subject.por.fl_str_mv |
Diclofenaco de Sódio Anastomose Cirúrgica Intestino Delgado |
topic |
Diclofenaco de Sódio Anastomose Cirúrgica Intestino Delgado |
description |
The effect of the diclofenac sodium (DS) on the healing of anastomosis carried- out in the ileum of rats was studied. Five- hundred and nineteen Wistar rats were randomly assigned to the 4 experimental groups: Group I included 52 rats treated with 3 mg/kg/day of saline, administered intramusculary during 4 days, group II included 110 rats submitted to ileal anastomosis and treated with saline as described previously, group III included 52 rats treated with DS in a dose of 3 mg/kg/day, administered IM during 4 days, and group IV included 295 rats submitted to ileal anastomosis and treated with DS as prior described. In all rats from the 4 experimental groups clinical parameters and measurements of tensile strength, tissue collagen and histological analyses were documented at 4, 7, 14, and 21 postoperative days. There are no clinical alterations in group I rats all over the study. Diarrhoea was observed in 8 rats (15,4%) from group III. In this group both tensile strenght and tissue collagen were descrease when compared with group I rats. Mortality in DS treated rats submitted to ileal anastomosis was higher than those of control groups. In group IV we also observed reard in the healing, with intense PMN inflamatory response, decrease of macrophages and of tissue collagen, and mucosae regeneration. We concluded that DS is deleterious on the healing of anastomosis performed in the ileum of rats |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000100006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000100006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86501998000100006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.13 n.1 1998 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126435065069568 |