Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000100010 |
Resumo: | PURPOSE: To compare the hemodynamic repercussions following a toxic dose of levobupivacaine and bupivacaine intravascularly injected in swines. Methods: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus injection of 4 mg/kg of either agent for intoxication. Hemodynamic results were then evaluated at 1, 5, 10, 15, 20 and 30 minutes. RESULTS: Levobupivacaine had greater hemodynamic repercussions than racemic bupivacaine. These results disagree with those found when the levorotatory isomer of bupivacaine was used in humans, but are in agreement with recently reported findings in animals. CONCLUSION: Levobupivacaine was shown to be more toxic in pigs than racemic bupivacaine when large doses are injected intravenously. |
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Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaineBupivacaineAnesthesia, LocalSwinePURPOSE: To compare the hemodynamic repercussions following a toxic dose of levobupivacaine and bupivacaine intravascularly injected in swines. Methods: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus injection of 4 mg/kg of either agent for intoxication. Hemodynamic results were then evaluated at 1, 5, 10, 15, 20 and 30 minutes. RESULTS: Levobupivacaine had greater hemodynamic repercussions than racemic bupivacaine. These results disagree with those found when the levorotatory isomer of bupivacaine was used in humans, but are in agreement with recently reported findings in animals. CONCLUSION: Levobupivacaine was shown to be more toxic in pigs than racemic bupivacaine when large doses are injected intravenously.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2008-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000100010Acta Cirúrgica Brasileira v.23 n.1 2008reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502008000100010info:eu-repo/semantics/openAccessUdelsmann,ArturLorena,Sílvia Elaine Rodolfo de SáGirioli,Samira UbaidSilva,William AdalbertoMoraes,Ana Cristina deAndreollo,Nelson Adamieng2008-03-27T00:00:00Zoai:scielo:S0102-86502008000100010Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-03-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine |
title |
Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine |
spellingShingle |
Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine Udelsmann,Artur Bupivacaine Anesthesia, Local Swine |
title_short |
Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine |
title_full |
Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine |
title_fullStr |
Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine |
title_full_unstemmed |
Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine |
title_sort |
Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine |
author |
Udelsmann,Artur |
author_facet |
Udelsmann,Artur Lorena,Sílvia Elaine Rodolfo de Sá Girioli,Samira Ubaid Silva,William Adalberto Moraes,Ana Cristina de Andreollo,Nelson Adami |
author_role |
author |
author2 |
Lorena,Sílvia Elaine Rodolfo de Sá Girioli,Samira Ubaid Silva,William Adalberto Moraes,Ana Cristina de Andreollo,Nelson Adami |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Udelsmann,Artur Lorena,Sílvia Elaine Rodolfo de Sá Girioli,Samira Ubaid Silva,William Adalberto Moraes,Ana Cristina de Andreollo,Nelson Adami |
dc.subject.por.fl_str_mv |
Bupivacaine Anesthesia, Local Swine |
topic |
Bupivacaine Anesthesia, Local Swine |
description |
PURPOSE: To compare the hemodynamic repercussions following a toxic dose of levobupivacaine and bupivacaine intravascularly injected in swines. Methods: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus injection of 4 mg/kg of either agent for intoxication. Hemodynamic results were then evaluated at 1, 5, 10, 15, 20 and 30 minutes. RESULTS: Levobupivacaine had greater hemodynamic repercussions than racemic bupivacaine. These results disagree with those found when the levorotatory isomer of bupivacaine was used in humans, but are in agreement with recently reported findings in animals. CONCLUSION: Levobupivacaine was shown to be more toxic in pigs than racemic bupivacaine when large doses are injected intravenously. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000100010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000100010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502008000100010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.23 n.1 2008 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126439059095552 |