Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study

Detalhes bibliográficos
Autor(a) principal: Silva,Marcello Henrique Araújo da
Data de Publicação: 2021
Outros Autores: Estrada,João Henrique Duque, Gregório,Bianca Martins, Sampaio,Francisco José Barcellos, Souza,Diogo Benchimol de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000700206
Resumo: ABSTRACT Purpose: To investigate whether renal modifications occur following treatment with dutasteride or finasteride. Methods: Twenty-four male rats were divided into three groups: control (that received distilled water), dutasteride (0.5 mg/kg/day), and finasteride (5 mg/kg/day) groups. All administrations were given by gavage for 40 consecutive days. After inducing euthanasia, blood was collected for urea and creatinine analyses, and both the kidneys were collected for stereological analyses of kidney morphology. Results: Serum urea and creatinine levels were increased in both the finasteride and the dutasteride groups compared with those in the control group. In addition, kidney weight, kidney volume, cortical volume, glomerular volumetric density, and mean glomerular volume were reduced in both treatment groups. Finally, the number of glomeruli per kidney was reduced by 26.8% in the finasteride group and by 51.6% in the dutasteride group compared with that in the control group. Conclusions: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.
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spelling Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental studyProstatic HyperplasiaDutasterideFinasterideKidneyModelsAnimalABSTRACT Purpose: To investigate whether renal modifications occur following treatment with dutasteride or finasteride. Methods: Twenty-four male rats were divided into three groups: control (that received distilled water), dutasteride (0.5 mg/kg/day), and finasteride (5 mg/kg/day) groups. All administrations were given by gavage for 40 consecutive days. After inducing euthanasia, blood was collected for urea and creatinine analyses, and both the kidneys were collected for stereological analyses of kidney morphology. Results: Serum urea and creatinine levels were increased in both the finasteride and the dutasteride groups compared with those in the control group. In addition, kidney weight, kidney volume, cortical volume, glomerular volumetric density, and mean glomerular volume were reduced in both treatment groups. Finally, the number of glomeruli per kidney was reduced by 26.8% in the finasteride group and by 51.6% in the dutasteride group compared with that in the control group. Conclusions: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000700206Acta Cirúrgica Brasileira v.36 n.7 2021reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/acb360703info:eu-repo/semantics/openAccessSilva,Marcello Henrique Araújo daEstrada,João Henrique DuqueGregório,Bianca MartinsSampaio,Francisco José BarcellosSouza,Diogo Benchimol deeng2021-09-13T00:00:00Zoai:scielo:S0102-86502021000700206Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2021-09-13T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
title Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
spellingShingle Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
Silva,Marcello Henrique Araújo da
Prostatic Hyperplasia
Dutasteride
Finasteride
Kidney
Models
Animal
title_short Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
title_full Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
title_fullStr Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
title_full_unstemmed Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
title_sort Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
author Silva,Marcello Henrique Araújo da
author_facet Silva,Marcello Henrique Araújo da
Estrada,João Henrique Duque
Gregório,Bianca Martins
Sampaio,Francisco José Barcellos
Souza,Diogo Benchimol de
author_role author
author2 Estrada,João Henrique Duque
Gregório,Bianca Martins
Sampaio,Francisco José Barcellos
Souza,Diogo Benchimol de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva,Marcello Henrique Araújo da
Estrada,João Henrique Duque
Gregório,Bianca Martins
Sampaio,Francisco José Barcellos
Souza,Diogo Benchimol de
dc.subject.por.fl_str_mv Prostatic Hyperplasia
Dutasteride
Finasteride
Kidney
Models
Animal
topic Prostatic Hyperplasia
Dutasteride
Finasteride
Kidney
Models
Animal
description ABSTRACT Purpose: To investigate whether renal modifications occur following treatment with dutasteride or finasteride. Methods: Twenty-four male rats were divided into three groups: control (that received distilled water), dutasteride (0.5 mg/kg/day), and finasteride (5 mg/kg/day) groups. All administrations were given by gavage for 40 consecutive days. After inducing euthanasia, blood was collected for urea and creatinine analyses, and both the kidneys were collected for stereological analyses of kidney morphology. Results: Serum urea and creatinine levels were increased in both the finasteride and the dutasteride groups compared with those in the control group. In addition, kidney weight, kidney volume, cortical volume, glomerular volumetric density, and mean glomerular volume were reduced in both treatment groups. Finally, the number of glomeruli per kidney was reduced by 26.8% in the finasteride group and by 51.6% in the dutasteride group compared with that in the control group. Conclusions: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000700206
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000700206
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/acb360703
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.36 n.7 2021
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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