The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001000816 |
Resumo: | Abstract Purpose: Topical hypothermia and local ischemic preconditioning have been shown to reduce renal ischemia-reperfusion (I/R) injury individually. We examined whether combination of both strategies lessens renal I/R injury. Methods: Post right nephrectomy, 40 male Wistar rats were randomly assigned to five experimental protocols performed in the left kidney: topical hypothermia without ischemia (TH), warm ischemia (IR), ischemic preconditioning followed by warm ischemia (IPC+IR), cold ischemia (TH+IR), and ischemic preconditioning followed by cold ischemia (IPC+TH+IR). Eight randomly assigned right kidneys constituted the control group. After 240 min of reperfusion, the left kidney was retrieved to evaluate histological changes, lipid peroxidation and antioxidant enzymes activity. Serum was collected to evaluate urea and creatinine. Results: IPC+TH+IR group revealed no difference to any other group subjected to ischemia in relation to histological changes, lipid peroxidation and antioxidant enzymes activity. Creatinine was lower in IPC+TH+IR group compared with IPC+IR, but showed no difference compared to TH+IR group. Conclusions: Combination of local ischemic preconditioning (IPC) and topical hypothermia conferred no protection in renal I/R injury. Moreover, local IPC solely followed by warm ischemia impaired renal function more than warm ischemia alone. |
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The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in ratsIschemic PreconditioningHypothermiaReperfusion InjuryOxidative StressKidneyRatsAbstract Purpose: Topical hypothermia and local ischemic preconditioning have been shown to reduce renal ischemia-reperfusion (I/R) injury individually. We examined whether combination of both strategies lessens renal I/R injury. Methods: Post right nephrectomy, 40 male Wistar rats were randomly assigned to five experimental protocols performed in the left kidney: topical hypothermia without ischemia (TH), warm ischemia (IR), ischemic preconditioning followed by warm ischemia (IPC+IR), cold ischemia (TH+IR), and ischemic preconditioning followed by cold ischemia (IPC+TH+IR). Eight randomly assigned right kidneys constituted the control group. After 240 min of reperfusion, the left kidney was retrieved to evaluate histological changes, lipid peroxidation and antioxidant enzymes activity. Serum was collected to evaluate urea and creatinine. Results: IPC+TH+IR group revealed no difference to any other group subjected to ischemia in relation to histological changes, lipid peroxidation and antioxidant enzymes activity. Creatinine was lower in IPC+TH+IR group compared with IPC+IR, but showed no difference compared to TH+IR group. Conclusions: Combination of local ischemic preconditioning (IPC) and topical hypothermia conferred no protection in renal I/R injury. Moreover, local IPC solely followed by warm ischemia impaired renal function more than warm ischemia alone.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001000816Acta Cirúrgica Brasileira v.32 n.10 2017reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020170100000003info:eu-repo/semantics/openAccessRibeiro,Guilherme BehrendSantos,Emanuel Burck dosBona,Silvia ReginaSchaefer,Pedro GuilhermeGarcez,Tuane AlvesRabolini,Eduardo BrasilSmaniotto,Guilherme PereiraMarroni,Norma PossaCorso,Carlos Otávioeng2017-11-08T00:00:00Zoai:scielo:S0102-86502017001000816Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-11-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats |
title |
The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats |
spellingShingle |
The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats Ribeiro,Guilherme Behrend Ischemic Preconditioning Hypothermia Reperfusion Injury Oxidative Stress Kidney Rats |
title_short |
The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats |
title_full |
The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats |
title_fullStr |
The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats |
title_full_unstemmed |
The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats |
title_sort |
The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats |
author |
Ribeiro,Guilherme Behrend |
author_facet |
Ribeiro,Guilherme Behrend Santos,Emanuel Burck dos Bona,Silvia Regina Schaefer,Pedro Guilherme Garcez,Tuane Alves Rabolini,Eduardo Brasil Smaniotto,Guilherme Pereira Marroni,Norma Possa Corso,Carlos Otávio |
author_role |
author |
author2 |
Santos,Emanuel Burck dos Bona,Silvia Regina Schaefer,Pedro Guilherme Garcez,Tuane Alves Rabolini,Eduardo Brasil Smaniotto,Guilherme Pereira Marroni,Norma Possa Corso,Carlos Otávio |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ribeiro,Guilherme Behrend Santos,Emanuel Burck dos Bona,Silvia Regina Schaefer,Pedro Guilherme Garcez,Tuane Alves Rabolini,Eduardo Brasil Smaniotto,Guilherme Pereira Marroni,Norma Possa Corso,Carlos Otávio |
dc.subject.por.fl_str_mv |
Ischemic Preconditioning Hypothermia Reperfusion Injury Oxidative Stress Kidney Rats |
topic |
Ischemic Preconditioning Hypothermia Reperfusion Injury Oxidative Stress Kidney Rats |
description |
Abstract Purpose: Topical hypothermia and local ischemic preconditioning have been shown to reduce renal ischemia-reperfusion (I/R) injury individually. We examined whether combination of both strategies lessens renal I/R injury. Methods: Post right nephrectomy, 40 male Wistar rats were randomly assigned to five experimental protocols performed in the left kidney: topical hypothermia without ischemia (TH), warm ischemia (IR), ischemic preconditioning followed by warm ischemia (IPC+IR), cold ischemia (TH+IR), and ischemic preconditioning followed by cold ischemia (IPC+TH+IR). Eight randomly assigned right kidneys constituted the control group. After 240 min of reperfusion, the left kidney was retrieved to evaluate histological changes, lipid peroxidation and antioxidant enzymes activity. Serum was collected to evaluate urea and creatinine. Results: IPC+TH+IR group revealed no difference to any other group subjected to ischemia in relation to histological changes, lipid peroxidation and antioxidant enzymes activity. Creatinine was lower in IPC+TH+IR group compared with IPC+IR, but showed no difference compared to TH+IR group. Conclusions: Combination of local ischemic preconditioning (IPC) and topical hypothermia conferred no protection in renal I/R injury. Moreover, local IPC solely followed by warm ischemia impaired renal function more than warm ischemia alone. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001000816 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001000816 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020170100000003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.32 n.10 2017 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126444512739328 |