Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case report
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | BrJP (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922022000200178 |
Resumo: | ABSTRACT BACKGROUND AND OBJECTIVES: The design of research with monozygotic twins discordant for the disease has emerged as a powerful tool for the detection of phenotypic risk factors. The aim of this study is to report a clinical case of monozygotic twins discordant for pain-related temporomandibular joint disorder (TMD) from a cognitive-behavioral-emotional phenotypic analysis, from the comparison of clinical variables of pain, history of exposure to painful procedures in early childhood, and coping with pain. CASE REPORT: TMD-Twin presented a diagnosis of painful (myofascial pain with referral) and joint (disk displacement with reduction) TMD according to the criteria of the DC/TMD. Control-Twin did not show TMD, however she presented other chronic pains. TMD-Twin showed reduced pressure pain threshold, hyperalgesia in trigeminal and extra-trigeminal regions compared to the Control-Twin. TMD-Twin was more exposed to painful procedures and emotional events due to congenital heart problems. Both had central sensitization based on the Central Sensitization Inventory, although TMD-Twin had more catastrophic thoughts about pain. TMD-Twin presented an internal locus of control. CONCLUSION: Both monozygotic twins presented a chronic pain phenotype, although they were discordant with the TMD-related pain. The main differences were the lower pressure pain threshold and higher hyperalgesia locally presented by TMD-Twin. The internal locus of control indicates greater pain sensitivity, with better coping of the painful experience for the TMD-Twin. One possible explanation for this clinical condition can be that painful experiences in early childhood have shaped a phenotype of greater sensitivity with better coping and resilience to the painful condition. |
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Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case reportChronic painFacial painMonozygotic twinTemporomandibular joint disordersCentral nervous system sensitizationABSTRACT BACKGROUND AND OBJECTIVES: The design of research with monozygotic twins discordant for the disease has emerged as a powerful tool for the detection of phenotypic risk factors. The aim of this study is to report a clinical case of monozygotic twins discordant for pain-related temporomandibular joint disorder (TMD) from a cognitive-behavioral-emotional phenotypic analysis, from the comparison of clinical variables of pain, history of exposure to painful procedures in early childhood, and coping with pain. CASE REPORT: TMD-Twin presented a diagnosis of painful (myofascial pain with referral) and joint (disk displacement with reduction) TMD according to the criteria of the DC/TMD. Control-Twin did not show TMD, however she presented other chronic pains. TMD-Twin showed reduced pressure pain threshold, hyperalgesia in trigeminal and extra-trigeminal regions compared to the Control-Twin. TMD-Twin was more exposed to painful procedures and emotional events due to congenital heart problems. Both had central sensitization based on the Central Sensitization Inventory, although TMD-Twin had more catastrophic thoughts about pain. TMD-Twin presented an internal locus of control. CONCLUSION: Both monozygotic twins presented a chronic pain phenotype, although they were discordant with the TMD-related pain. The main differences were the lower pressure pain threshold and higher hyperalgesia locally presented by TMD-Twin. The internal locus of control indicates greater pain sensitivity, with better coping of the painful experience for the TMD-Twin. One possible explanation for this clinical condition can be that painful experiences in early childhood have shaped a phenotype of greater sensitivity with better coping and resilience to the painful condition.Sociedade Brasileira para o Estudo da Dor2022-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922022000200178BrJP v.5 n.2 2022reponame:BrJP (Online)instname:Sociedade Brasileira para o Estudo da Dor (SBED)instacron:SBED10.5935/2595-0118.20220021info:eu-repo/semantics/openAccessMagri,Lais ValenciseMelchior,Melissa de Oliveirada-Silva,Graziela ValleGherardi-Donato,Edilaine Cristina SilvaLeite-Panissi,Christie Ramos Andradeeng2022-06-28T00:00:00Zoai:scielo:S2595-31922022000200178Revistahttps://sbed.org.br/publicacoes-publicacoes-bjp/ONGhttps://old.scielo.br/oai/scielo-oai.phpdkt@terra.com.br || dor@dor.org.br2595-31922595-0118opendoar:2022-06-28T00:00BrJP (Online) - Sociedade Brasileira para o Estudo da Dor (SBED)false |
dc.title.none.fl_str_mv |
Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case report |
title |
Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case report |
spellingShingle |
Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case report Magri,Lais Valencise Chronic pain Facial pain Monozygotic twin Temporomandibular joint disorders Central nervous system sensitization |
title_short |
Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case report |
title_full |
Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case report |
title_fullStr |
Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case report |
title_full_unstemmed |
Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case report |
title_sort |
Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. Case report |
author |
Magri,Lais Valencise |
author_facet |
Magri,Lais Valencise Melchior,Melissa de Oliveira da-Silva,Graziela Valle Gherardi-Donato,Edilaine Cristina Silva Leite-Panissi,Christie Ramos Andrade |
author_role |
author |
author2 |
Melchior,Melissa de Oliveira da-Silva,Graziela Valle Gherardi-Donato,Edilaine Cristina Silva Leite-Panissi,Christie Ramos Andrade |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Magri,Lais Valencise Melchior,Melissa de Oliveira da-Silva,Graziela Valle Gherardi-Donato,Edilaine Cristina Silva Leite-Panissi,Christie Ramos Andrade |
dc.subject.por.fl_str_mv |
Chronic pain Facial pain Monozygotic twin Temporomandibular joint disorders Central nervous system sensitization |
topic |
Chronic pain Facial pain Monozygotic twin Temporomandibular joint disorders Central nervous system sensitization |
description |
ABSTRACT BACKGROUND AND OBJECTIVES: The design of research with monozygotic twins discordant for the disease has emerged as a powerful tool for the detection of phenotypic risk factors. The aim of this study is to report a clinical case of monozygotic twins discordant for pain-related temporomandibular joint disorder (TMD) from a cognitive-behavioral-emotional phenotypic analysis, from the comparison of clinical variables of pain, history of exposure to painful procedures in early childhood, and coping with pain. CASE REPORT: TMD-Twin presented a diagnosis of painful (myofascial pain with referral) and joint (disk displacement with reduction) TMD according to the criteria of the DC/TMD. Control-Twin did not show TMD, however she presented other chronic pains. TMD-Twin showed reduced pressure pain threshold, hyperalgesia in trigeminal and extra-trigeminal regions compared to the Control-Twin. TMD-Twin was more exposed to painful procedures and emotional events due to congenital heart problems. Both had central sensitization based on the Central Sensitization Inventory, although TMD-Twin had more catastrophic thoughts about pain. TMD-Twin presented an internal locus of control. CONCLUSION: Both monozygotic twins presented a chronic pain phenotype, although they were discordant with the TMD-related pain. The main differences were the lower pressure pain threshold and higher hyperalgesia locally presented by TMD-Twin. The internal locus of control indicates greater pain sensitivity, with better coping of the painful experience for the TMD-Twin. One possible explanation for this clinical condition can be that painful experiences in early childhood have shaped a phenotype of greater sensitivity with better coping and resilience to the painful condition. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922022000200178 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922022000200178 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/2595-0118.20220021 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Estudo da Dor |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Estudo da Dor |
dc.source.none.fl_str_mv |
BrJP v.5 n.2 2022 reponame:BrJP (Online) instname:Sociedade Brasileira para o Estudo da Dor (SBED) instacron:SBED |
instname_str |
Sociedade Brasileira para o Estudo da Dor (SBED) |
instacron_str |
SBED |
institution |
SBED |
reponame_str |
BrJP (Online) |
collection |
BrJP (Online) |
repository.name.fl_str_mv |
BrJP (Online) - Sociedade Brasileira para o Estudo da Dor (SBED) |
repository.mail.fl_str_mv |
dkt@terra.com.br || dor@dor.org.br |
_version_ |
1754732510954127360 |