Choosing statins: a review to guide clinical practice

Bibliographic Details
Main Author: Borges,Roberta de Pádua
Publication Date: 2020
Other Authors: Degobi,Nathália Abi Habib, Bertoluci,Marcello Casaccia
Format: Article
Language: eng
Source: Arquivos de Endocrinologia e Metabolismo (Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600639
Summary: ABSTRACT Statins are among the most widely prescribed medicines in the world and have proved their value in reducing cardiovascular events and mortality. Many patients report adverse effects that lead to interruption of treatment. This review aims to individualize statin treatment, considering efficacy for reducing cardiovascular risk and safety, in the setting of specific diseases, to minimize the side effects and improve compliance. We gathered evidence that may help clinicians to choose specific statins in different clinical situations, such as the risk of new diabetes, chronic kidney disease, liver disease, human immunodeficiency virus infection, organ transplant, heart failure and elderly people. Efficacy of statins is well established in a large number of clinical conditions. Therefore, main objective is to revise statin in specific clinical settings, based on pharmacokinetics, safety, drug metabolism and interactions to provide the best choice in different clinical scenarios.
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spelling Choosing statins: a review to guide clinical practiceStatinscardiovascular diseasecholesteroltype 2 diabetesABSTRACT Statins are among the most widely prescribed medicines in the world and have proved their value in reducing cardiovascular events and mortality. Many patients report adverse effects that lead to interruption of treatment. This review aims to individualize statin treatment, considering efficacy for reducing cardiovascular risk and safety, in the setting of specific diseases, to minimize the side effects and improve compliance. We gathered evidence that may help clinicians to choose specific statins in different clinical situations, such as the risk of new diabetes, chronic kidney disease, liver disease, human immunodeficiency virus infection, organ transplant, heart failure and elderly people. Efficacy of statins is well established in a large number of clinical conditions. Therefore, main objective is to revise statin in specific clinical settings, based on pharmacokinetics, safety, drug metabolism and interactions to provide the best choice in different clinical scenarios.Sociedade Brasileira de Endocrinologia e Metabologia2020-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600639Archives of Endocrinology and Metabolism v.64 n.6 2020reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000306info:eu-repo/semantics/openAccessBorges,Roberta de PáduaDegobi,Nathália Abi HabibBertoluci,Marcello Casacciaeng2021-02-25T00:00:00Zoai:scielo:S2359-39972020000600639Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2021-02-25T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Choosing statins: a review to guide clinical practice
title Choosing statins: a review to guide clinical practice
spellingShingle Choosing statins: a review to guide clinical practice
Borges,Roberta de Pádua
Statins
cardiovascular disease
cholesterol
type 2 diabetes
title_short Choosing statins: a review to guide clinical practice
title_full Choosing statins: a review to guide clinical practice
title_fullStr Choosing statins: a review to guide clinical practice
title_full_unstemmed Choosing statins: a review to guide clinical practice
title_sort Choosing statins: a review to guide clinical practice
author Borges,Roberta de Pádua
author_facet Borges,Roberta de Pádua
Degobi,Nathália Abi Habib
Bertoluci,Marcello Casaccia
author_role author
author2 Degobi,Nathália Abi Habib
Bertoluci,Marcello Casaccia
author2_role author
author
dc.contributor.author.fl_str_mv Borges,Roberta de Pádua
Degobi,Nathália Abi Habib
Bertoluci,Marcello Casaccia
dc.subject.por.fl_str_mv Statins
cardiovascular disease
cholesterol
type 2 diabetes
topic Statins
cardiovascular disease
cholesterol
type 2 diabetes
description ABSTRACT Statins are among the most widely prescribed medicines in the world and have proved their value in reducing cardiovascular events and mortality. Many patients report adverse effects that lead to interruption of treatment. This review aims to individualize statin treatment, considering efficacy for reducing cardiovascular risk and safety, in the setting of specific diseases, to minimize the side effects and improve compliance. We gathered evidence that may help clinicians to choose specific statins in different clinical situations, such as the risk of new diabetes, chronic kidney disease, liver disease, human immunodeficiency virus infection, organ transplant, heart failure and elderly people. Efficacy of statins is well established in a large number of clinical conditions. Therefore, main objective is to revise statin in specific clinical settings, based on pharmacokinetics, safety, drug metabolism and interactions to provide the best choice in different clinical scenarios.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600639
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600639
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.20945/2359-3997000000306
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Archives of Endocrinology and Metabolism v.64 n.6 2020
reponame:Arquivos de Endocrinologia e Metabolismo (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos de Endocrinologia e Metabolismo (Online)
collection Arquivos de Endocrinologia e Metabolismo (Online)
repository.name.fl_str_mv Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||aem.editorial.office@endocrino.org.br
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