Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma

Detalhes bibliográficos
Autor(a) principal: Siviero-Miachon,Adriana Aparecida
Data de Publicação: 2011
Outros Autores: Monteiro,Carlos Manoel de Castro, Pires,Liliane Viana, Rozalem,Ana Carolina, Silva,Nasjla Saba da, Petrilli,Antonio Sergio, Spinola-Castro,Angela Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800022
Resumo: OBJECTIVE: To analyze traits of metabolic syndrome (MetS) in medulloblastoma survivors. SUBJECTS AND METHODS: Sixteen childhood medulloblastoma survivors aged 18.0 (4.4) years, with history of craniospinal radiation therapy (RT) were compared with nine control subjects matched by age, gender, and body mass index, according to fat distribution, metabolic and cardiovascular variables. RESULTS: Medulloblastoma patients showed increases in waist circum-ference and its relationships (all p < 0.05), and HOMA1-IR (p = 0.006), which were modified by growth hormone (GH) secretion status. However, these increases were within normal range. CONCLUSIONS: Adolescent and young adult survivors of medulloblastoma showed centripetal fat deposition and decreased insulin sensitivity, associated with GH status. Pediatric brain tumor survivors following RT should be monitored for the diagnosis of MetS traits predisposing to cardiovascular disease.
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spelling Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastomaMedulloblastoma/therapymedulloblastoma/drug therapymedulloblastoma/radiotherapymedulloblastoma/prevention and controlcardiovascular diseasesmetabolic syndrome XOBJECTIVE: To analyze traits of metabolic syndrome (MetS) in medulloblastoma survivors. SUBJECTS AND METHODS: Sixteen childhood medulloblastoma survivors aged 18.0 (4.4) years, with history of craniospinal radiation therapy (RT) were compared with nine control subjects matched by age, gender, and body mass index, according to fat distribution, metabolic and cardiovascular variables. RESULTS: Medulloblastoma patients showed increases in waist circum-ference and its relationships (all p < 0.05), and HOMA1-IR (p = 0.006), which were modified by growth hormone (GH) secretion status. However, these increases were within normal range. CONCLUSIONS: Adolescent and young adult survivors of medulloblastoma showed centripetal fat deposition and decreased insulin sensitivity, associated with GH status. Pediatric brain tumor survivors following RT should be monitored for the diagnosis of MetS traits predisposing to cardiovascular disease.Sociedade Brasileira de Endocrinologia e Metabologia2011-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800022Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.55 n.8 2011reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302011000800022info:eu-repo/semantics/openAccessSiviero-Miachon,Adriana AparecidaMonteiro,Carlos Manoel de CastroPires,Liliane VianaRozalem,Ana CarolinaSilva,Nasjla Saba daPetrilli,Antonio SergioSpinola-Castro,Angela Mariaeng2012-01-03T00:00:00Zoai:scielo:S0004-27302011000800022Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2012-01-03T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
title Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
spellingShingle Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
Siviero-Miachon,Adriana Aparecida
Medulloblastoma/therapy
medulloblastoma/drug therapy
medulloblastoma/radiotherapy
medulloblastoma/prevention and control
cardiovascular diseases
metabolic syndrome X
title_short Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
title_full Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
title_fullStr Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
title_full_unstemmed Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
title_sort Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
author Siviero-Miachon,Adriana Aparecida
author_facet Siviero-Miachon,Adriana Aparecida
Monteiro,Carlos Manoel de Castro
Pires,Liliane Viana
Rozalem,Ana Carolina
Silva,Nasjla Saba da
Petrilli,Antonio Sergio
Spinola-Castro,Angela Maria
author_role author
author2 Monteiro,Carlos Manoel de Castro
Pires,Liliane Viana
Rozalem,Ana Carolina
Silva,Nasjla Saba da
Petrilli,Antonio Sergio
Spinola-Castro,Angela Maria
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Siviero-Miachon,Adriana Aparecida
Monteiro,Carlos Manoel de Castro
Pires,Liliane Viana
Rozalem,Ana Carolina
Silva,Nasjla Saba da
Petrilli,Antonio Sergio
Spinola-Castro,Angela Maria
dc.subject.por.fl_str_mv Medulloblastoma/therapy
medulloblastoma/drug therapy
medulloblastoma/radiotherapy
medulloblastoma/prevention and control
cardiovascular diseases
metabolic syndrome X
topic Medulloblastoma/therapy
medulloblastoma/drug therapy
medulloblastoma/radiotherapy
medulloblastoma/prevention and control
cardiovascular diseases
metabolic syndrome X
description OBJECTIVE: To analyze traits of metabolic syndrome (MetS) in medulloblastoma survivors. SUBJECTS AND METHODS: Sixteen childhood medulloblastoma survivors aged 18.0 (4.4) years, with history of craniospinal radiation therapy (RT) were compared with nine control subjects matched by age, gender, and body mass index, according to fat distribution, metabolic and cardiovascular variables. RESULTS: Medulloblastoma patients showed increases in waist circum-ference and its relationships (all p < 0.05), and HOMA1-IR (p = 0.006), which were modified by growth hormone (GH) secretion status. However, these increases were within normal range. CONCLUSIONS: Adolescent and young adult survivors of medulloblastoma showed centripetal fat deposition and decreased insulin sensitivity, associated with GH status. Pediatric brain tumor survivors following RT should be monitored for the diagnosis of MetS traits predisposing to cardiovascular disease.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302011000800022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.55 n.8 2011
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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