Apo B/Apo A-I ratio in central and peripheral arterial diseases

Detalhes bibliográficos
Autor(a) principal: Lima,Luciana M.
Data de Publicação: 2007
Outros Autores: Carvalho,Maria das Graças, Sabino,Adriano de P., Mota,Ana P.L., Fernandes,Ana P., Sousa,Marinez O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000700020
Resumo: BACKGROUND: The apo B/apo A-I ratio represents the balance between atherogenic particles, rich in apo B, and the antiatherogenic ones, apo A-I rich. This study investigated the association between atherosclerotic diseases in different anatomical sites and apo B/apo A-I ratio. METHODS: Lipids, lipoproteins, and apolipoproteins A-I and B were assessed in 30 subjects with coronary artery disease (CAD), 26 with ischemic stroke (IS), 30 with peripheral arterial obstructive disease (PAOD), and 38 healthy subjects (controls). RESULTS: HDLc and Apo A-I were significantly lower in PAOD and CAD groups, respectively, than in other groups. Significantly higher levels of triglycerides were observed for CAD and PAOD groups than for controls. Apo B was significantly higher in IS group than in control and PAOD groups. The apo B/apo A-I ratio showed significantly higher in CAD and IS groups when compared to control and PAOD groups (p < 0.001). CONCLUSION: The apo B/apo A-I ratio was important for identifying an increased trend for coronary and cerebral atherosclerosis. In spite of the increased trend for apo B/apo A-I ratio in IS and CAD groups, the studied variables cannot be considered in an isolated way, given as those parameters were analyzed together by a binary logistic regression, no association has been demonstrated.
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spelling Apo B/Apo A-I ratio in central and peripheral arterial diseasesApolipoproteins A-I and BCoronary artery diseaseIschemic strokePeripheral arterial obstructive diseaseBACKGROUND: The apo B/apo A-I ratio represents the balance between atherogenic particles, rich in apo B, and the antiatherogenic ones, apo A-I rich. This study investigated the association between atherosclerotic diseases in different anatomical sites and apo B/apo A-I ratio. METHODS: Lipids, lipoproteins, and apolipoproteins A-I and B were assessed in 30 subjects with coronary artery disease (CAD), 26 with ischemic stroke (IS), 30 with peripheral arterial obstructive disease (PAOD), and 38 healthy subjects (controls). RESULTS: HDLc and Apo A-I were significantly lower in PAOD and CAD groups, respectively, than in other groups. Significantly higher levels of triglycerides were observed for CAD and PAOD groups than for controls. Apo B was significantly higher in IS group than in control and PAOD groups. The apo B/apo A-I ratio showed significantly higher in CAD and IS groups when compared to control and PAOD groups (p < 0.001). CONCLUSION: The apo B/apo A-I ratio was important for identifying an increased trend for coronary and cerebral atherosclerosis. In spite of the increased trend for apo B/apo A-I ratio in IS and CAD groups, the studied variables cannot be considered in an isolated way, given as those parameters were analyzed together by a binary logistic regression, no association has been demonstrated.Sociedade Brasileira de Endocrinologia e Metabologia2007-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000700020Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.51 n.7 2007reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302007000700020info:eu-repo/semantics/openAccessLima,Luciana M.Carvalho,Maria das GraçasSabino,Adriano de P.Mota,Ana P.L.Fernandes,Ana P.Sousa,Marinez O.eng2007-12-17T00:00:00Zoai:scielo:S0004-27302007000700020Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2007-12-17T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Apo B/Apo A-I ratio in central and peripheral arterial diseases
title Apo B/Apo A-I ratio in central and peripheral arterial diseases
spellingShingle Apo B/Apo A-I ratio in central and peripheral arterial diseases
Lima,Luciana M.
Apolipoproteins A-I and B
Coronary artery disease
Ischemic stroke
Peripheral arterial obstructive disease
title_short Apo B/Apo A-I ratio in central and peripheral arterial diseases
title_full Apo B/Apo A-I ratio in central and peripheral arterial diseases
title_fullStr Apo B/Apo A-I ratio in central and peripheral arterial diseases
title_full_unstemmed Apo B/Apo A-I ratio in central and peripheral arterial diseases
title_sort Apo B/Apo A-I ratio in central and peripheral arterial diseases
author Lima,Luciana M.
author_facet Lima,Luciana M.
Carvalho,Maria das Graças
Sabino,Adriano de P.
Mota,Ana P.L.
Fernandes,Ana P.
Sousa,Marinez O.
author_role author
author2 Carvalho,Maria das Graças
Sabino,Adriano de P.
Mota,Ana P.L.
Fernandes,Ana P.
Sousa,Marinez O.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lima,Luciana M.
Carvalho,Maria das Graças
Sabino,Adriano de P.
Mota,Ana P.L.
Fernandes,Ana P.
Sousa,Marinez O.
dc.subject.por.fl_str_mv Apolipoproteins A-I and B
Coronary artery disease
Ischemic stroke
Peripheral arterial obstructive disease
topic Apolipoproteins A-I and B
Coronary artery disease
Ischemic stroke
Peripheral arterial obstructive disease
description BACKGROUND: The apo B/apo A-I ratio represents the balance between atherogenic particles, rich in apo B, and the antiatherogenic ones, apo A-I rich. This study investigated the association between atherosclerotic diseases in different anatomical sites and apo B/apo A-I ratio. METHODS: Lipids, lipoproteins, and apolipoproteins A-I and B were assessed in 30 subjects with coronary artery disease (CAD), 26 with ischemic stroke (IS), 30 with peripheral arterial obstructive disease (PAOD), and 38 healthy subjects (controls). RESULTS: HDLc and Apo A-I were significantly lower in PAOD and CAD groups, respectively, than in other groups. Significantly higher levels of triglycerides were observed for CAD and PAOD groups than for controls. Apo B was significantly higher in IS group than in control and PAOD groups. The apo B/apo A-I ratio showed significantly higher in CAD and IS groups when compared to control and PAOD groups (p < 0.001). CONCLUSION: The apo B/apo A-I ratio was important for identifying an increased trend for coronary and cerebral atherosclerosis. In spite of the increased trend for apo B/apo A-I ratio in IS and CAD groups, the studied variables cannot be considered in an isolated way, given as those parameters were analyzed together by a binary logistic regression, no association has been demonstrated.
publishDate 2007
dc.date.none.fl_str_mv 2007-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000700020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000700020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302007000700020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.51 n.7 2007
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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