Laboratory diagnosis of late-onset male hypogonadism andropause

Detalhes bibliográficos
Autor(a) principal: Clapauch,Ruth
Data de Publicação: 2008
Outros Autores: Carmo,Aline Machado, Marinheiro,Lizanka, Buksman,Salo, Pessoa,Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000900005
Resumo: OBJECTIVES: To evaluate which factors influence the laboratorial diagnosis of late-onset male hypogonadism (LOH). METHODS: Total testosterone (TT), SHBG and albumin were measured in 216 men aged 52-84 years. The laboratorial definition of LOH was two values of calculated free testosterone (cFT) <6.5 ng/dl, according to Vermeulen's formula. RESULTS: At the first blood test, cFT was <6.5 ng/dl in 27% of the men. Laboratorial LOH (confirmed by two tests) was present in 19%, but TT levels were low in only 4.1%. Age influenced TT (p=0.0051) as well as BMI; 23.5% of patients > 70 years and 38.9% of the obese men who had TT within the reference range were, in fact, hypogonadal. CONCLUSION: Especially in obese men and in those > 70 years old, SHBG dosage is important to calculate FT levels and diagnose hypogonadism.
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spelling Laboratory diagnosis of late-onset male hypogonadism andropauseAndropauseLate-onset male hypogonadismDiagnosisTotal testosteroneCalculated free testosteroneOBJECTIVES: To evaluate which factors influence the laboratorial diagnosis of late-onset male hypogonadism (LOH). METHODS: Total testosterone (TT), SHBG and albumin were measured in 216 men aged 52-84 years. The laboratorial definition of LOH was two values of calculated free testosterone (cFT) <6.5 ng/dl, according to Vermeulen's formula. RESULTS: At the first blood test, cFT was <6.5 ng/dl in 27% of the men. Laboratorial LOH (confirmed by two tests) was present in 19%, but TT levels were low in only 4.1%. Age influenced TT (p=0.0051) as well as BMI; 23.5% of patients > 70 years and 38.9% of the obese men who had TT within the reference range were, in fact, hypogonadal. CONCLUSION: Especially in obese men and in those > 70 years old, SHBG dosage is important to calculate FT levels and diagnose hypogonadism.Sociedade Brasileira de Endocrinologia e Metabologia2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000900005Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.52 n.9 2008reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302008000900005info:eu-repo/semantics/openAccessClapauch,RuthCarmo,Aline MachadoMarinheiro,LizankaBuksman,SaloPessoa,Isabeleng2009-02-02T00:00:00Zoai:scielo:S0004-27302008000900005Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2009-02-02T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Laboratory diagnosis of late-onset male hypogonadism andropause
title Laboratory diagnosis of late-onset male hypogonadism andropause
spellingShingle Laboratory diagnosis of late-onset male hypogonadism andropause
Clapauch,Ruth
Andropause
Late-onset male hypogonadism
Diagnosis
Total testosterone
Calculated free testosterone
title_short Laboratory diagnosis of late-onset male hypogonadism andropause
title_full Laboratory diagnosis of late-onset male hypogonadism andropause
title_fullStr Laboratory diagnosis of late-onset male hypogonadism andropause
title_full_unstemmed Laboratory diagnosis of late-onset male hypogonadism andropause
title_sort Laboratory diagnosis of late-onset male hypogonadism andropause
author Clapauch,Ruth
author_facet Clapauch,Ruth
Carmo,Aline Machado
Marinheiro,Lizanka
Buksman,Salo
Pessoa,Isabel
author_role author
author2 Carmo,Aline Machado
Marinheiro,Lizanka
Buksman,Salo
Pessoa,Isabel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Clapauch,Ruth
Carmo,Aline Machado
Marinheiro,Lizanka
Buksman,Salo
Pessoa,Isabel
dc.subject.por.fl_str_mv Andropause
Late-onset male hypogonadism
Diagnosis
Total testosterone
Calculated free testosterone
topic Andropause
Late-onset male hypogonadism
Diagnosis
Total testosterone
Calculated free testosterone
description OBJECTIVES: To evaluate which factors influence the laboratorial diagnosis of late-onset male hypogonadism (LOH). METHODS: Total testosterone (TT), SHBG and albumin were measured in 216 men aged 52-84 years. The laboratorial definition of LOH was two values of calculated free testosterone (cFT) <6.5 ng/dl, according to Vermeulen's formula. RESULTS: At the first blood test, cFT was <6.5 ng/dl in 27% of the men. Laboratorial LOH (confirmed by two tests) was present in 19%, but TT levels were low in only 4.1%. Age influenced TT (p=0.0051) as well as BMI; 23.5% of patients > 70 years and 38.9% of the obese men who had TT within the reference range were, in fact, hypogonadal. CONCLUSION: Especially in obese men and in those > 70 years old, SHBG dosage is important to calculate FT levels and diagnose hypogonadism.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000900005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000900005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302008000900005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.52 n.9 2008
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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