Normocalcemic primary hyperparathyroidism

Detalhes bibliográficos
Autor(a) principal: Bilezikian,John P.
Data de Publicação: 2010
Outros Autores: Silverberg,Shonni J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000200004
Resumo: Primary hyperparathyroidism is a common disorder of mineral metabolism characterized by incompletely regulated, excessive secretion of parathyroid hormone from one or more of the parathyroid glands. The historical view of this disease describes two distinct entities marked by two eras. When primary hyperparathyroidism was first discovered about 80 years ago, it was always symptomatic with kidney stones, bone disease and marked hypercalcemia. With the advent of the multichannel autoanalyzer about 40 years ago, the clinical phenotype changed to a disorder characterized by mild hypercalcemia and the absence of classical other features of the disease. We may now be entering a 3rd era in the history of this disease in which patients are being discovered with normal total and ionized serum calcium concentrations but with parathyroid hormone levels that are consistently elevated. In this article, we describe this new entity, normocalcemic primary hyperparathyroidism, a forme fruste of the disease.
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spelling Normocalcemic primary hyperparathyroidismNormocalcemic hyperparathyroidismcalciumbone diseasePrimary hyperparathyroidism is a common disorder of mineral metabolism characterized by incompletely regulated, excessive secretion of parathyroid hormone from one or more of the parathyroid glands. The historical view of this disease describes two distinct entities marked by two eras. When primary hyperparathyroidism was first discovered about 80 years ago, it was always symptomatic with kidney stones, bone disease and marked hypercalcemia. With the advent of the multichannel autoanalyzer about 40 years ago, the clinical phenotype changed to a disorder characterized by mild hypercalcemia and the absence of classical other features of the disease. We may now be entering a 3rd era in the history of this disease in which patients are being discovered with normal total and ionized serum calcium concentrations but with parathyroid hormone levels that are consistently elevated. In this article, we describe this new entity, normocalcemic primary hyperparathyroidism, a forme fruste of the disease.Sociedade Brasileira de Endocrinologia e Metabologia2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000200004Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.2 2010reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302010000200004info:eu-repo/semantics/openAccessBilezikian,John P.Silverberg,Shonni J.eng2010-05-21T00:00:00Zoai:scielo:S0004-27302010000200004Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2010-05-21T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Normocalcemic primary hyperparathyroidism
title Normocalcemic primary hyperparathyroidism
spellingShingle Normocalcemic primary hyperparathyroidism
Bilezikian,John P.
Normocalcemic hyperparathyroidism
calcium
bone disease
title_short Normocalcemic primary hyperparathyroidism
title_full Normocalcemic primary hyperparathyroidism
title_fullStr Normocalcemic primary hyperparathyroidism
title_full_unstemmed Normocalcemic primary hyperparathyroidism
title_sort Normocalcemic primary hyperparathyroidism
author Bilezikian,John P.
author_facet Bilezikian,John P.
Silverberg,Shonni J.
author_role author
author2 Silverberg,Shonni J.
author2_role author
dc.contributor.author.fl_str_mv Bilezikian,John P.
Silverberg,Shonni J.
dc.subject.por.fl_str_mv Normocalcemic hyperparathyroidism
calcium
bone disease
topic Normocalcemic hyperparathyroidism
calcium
bone disease
description Primary hyperparathyroidism is a common disorder of mineral metabolism characterized by incompletely regulated, excessive secretion of parathyroid hormone from one or more of the parathyroid glands. The historical view of this disease describes two distinct entities marked by two eras. When primary hyperparathyroidism was first discovered about 80 years ago, it was always symptomatic with kidney stones, bone disease and marked hypercalcemia. With the advent of the multichannel autoanalyzer about 40 years ago, the clinical phenotype changed to a disorder characterized by mild hypercalcemia and the absence of classical other features of the disease. We may now be entering a 3rd era in the history of this disease in which patients are being discovered with normal total and ionized serum calcium concentrations but with parathyroid hormone levels that are consistently elevated. In this article, we describe this new entity, normocalcemic primary hyperparathyroidism, a forme fruste of the disease.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-01
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dc.language.iso.fl_str_mv eng
language eng
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publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.2 2010
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