Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500018 |
Resumo: | Vasorelaxant effect of Hyptis fruticosa dichloromethane extract (HFDE) on isolated rings of rat mesenteric artery was evaluated in this study. In intact rings, HFDE (0.1-3000 µg/mL) induced concentration-dependent vasorelaxations (Emax = 119±14%; n = 6) of phenylephrine tonus that were not modified after endothelium removal (Emax = 116±6%; n = 6), after KCl 20 mM (Emax = 135±9%; n = 6) or in rings pre-contracted with KCl 80 mM (Emax = 125±4%; n = 6). In endothelium denuded rings, HFDE (300 or 1000 µg/mL) inhibited contractions induced by CaCl2 (maximal inhibition = 25±7% and 95±1%; respectively). Furthermore, HFDE promoted an additional vasorelaxation (15±3%; n = 7) after maximal response of 10 µM nifedipine (78±3%; n = 7). In conclusion, HFDE induces vasorelaxant effect through an endothelium-independent pathway, which appears to be due in major part to inhibition of the Ca2+ influx through voltage-operated Ca2+ channels. |
id |
SBFGNOSIA-1_219c314f19704674bc9f178fc2db475f |
---|---|
oai_identifier_str |
oai:scielo:S0102-695X2010000500018 |
network_acronym_str |
SBFGNOSIA-1 |
network_name_str |
Revista Brasileira de Farmacognosia (Online) |
repository_id_str |
|
spelling |
Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric arteryHyptis fruticosadichloromethane extractvasorelaxant effectmesenteric arteryratsVasorelaxant effect of Hyptis fruticosa dichloromethane extract (HFDE) on isolated rings of rat mesenteric artery was evaluated in this study. In intact rings, HFDE (0.1-3000 µg/mL) induced concentration-dependent vasorelaxations (Emax = 119±14%; n = 6) of phenylephrine tonus that were not modified after endothelium removal (Emax = 116±6%; n = 6), after KCl 20 mM (Emax = 135±9%; n = 6) or in rings pre-contracted with KCl 80 mM (Emax = 125±4%; n = 6). In endothelium denuded rings, HFDE (300 or 1000 µg/mL) inhibited contractions induced by CaCl2 (maximal inhibition = 25±7% and 95±1%; respectively). Furthermore, HFDE promoted an additional vasorelaxation (15±3%; n = 7) after maximal response of 10 µM nifedipine (78±3%; n = 7). In conclusion, HFDE induces vasorelaxant effect through an endothelium-independent pathway, which appears to be due in major part to inhibition of the Ca2+ influx through voltage-operated Ca2+ channels.Sociedade Brasileira de Farmacognosia2010-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500018Revista Brasileira de Farmacognosia v.20 n.5 2010reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2010005000003info:eu-repo/semantics/openAccessMoreira,Ítalo J. A.Moreno,Maria P. N.Fernandes,Maria F. G.Fernandes,João B.Moreira,Flávia V.Antoniolli,Ângelo R.Santos,Márcio R.V.eng2010-11-26T00:00:00Zoai:scielo:S0102-695X2010000500018Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2010-11-26T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery |
title |
Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery |
spellingShingle |
Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery Moreira,Ítalo J. A. Hyptis fruticosa dichloromethane extract vasorelaxant effect mesenteric artery rats |
title_short |
Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery |
title_full |
Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery |
title_fullStr |
Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery |
title_full_unstemmed |
Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery |
title_sort |
Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery |
author |
Moreira,Ítalo J. A. |
author_facet |
Moreira,Ítalo J. A. Moreno,Maria P. N. Fernandes,Maria F. G. Fernandes,João B. Moreira,Flávia V. Antoniolli,Ângelo R. Santos,Márcio R.V. |
author_role |
author |
author2 |
Moreno,Maria P. N. Fernandes,Maria F. G. Fernandes,João B. Moreira,Flávia V. Antoniolli,Ângelo R. Santos,Márcio R.V. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Moreira,Ítalo J. A. Moreno,Maria P. N. Fernandes,Maria F. G. Fernandes,João B. Moreira,Flávia V. Antoniolli,Ângelo R. Santos,Márcio R.V. |
dc.subject.por.fl_str_mv |
Hyptis fruticosa dichloromethane extract vasorelaxant effect mesenteric artery rats |
topic |
Hyptis fruticosa dichloromethane extract vasorelaxant effect mesenteric artery rats |
description |
Vasorelaxant effect of Hyptis fruticosa dichloromethane extract (HFDE) on isolated rings of rat mesenteric artery was evaluated in this study. In intact rings, HFDE (0.1-3000 µg/mL) induced concentration-dependent vasorelaxations (Emax = 119±14%; n = 6) of phenylephrine tonus that were not modified after endothelium removal (Emax = 116±6%; n = 6), after KCl 20 mM (Emax = 135±9%; n = 6) or in rings pre-contracted with KCl 80 mM (Emax = 125±4%; n = 6). In endothelium denuded rings, HFDE (300 or 1000 µg/mL) inhibited contractions induced by CaCl2 (maximal inhibition = 25±7% and 95±1%; respectively). Furthermore, HFDE promoted an additional vasorelaxation (15±3%; n = 7) after maximal response of 10 µM nifedipine (78±3%; n = 7). In conclusion, HFDE induces vasorelaxant effect through an endothelium-independent pathway, which appears to be due in major part to inhibition of the Ca2+ influx through voltage-operated Ca2+ channels. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2010005000003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.20 n.5 2010 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122464662454272 |