Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
| Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000600017 |
Resumo: | Rauvolfia ligustrina Willd. ex Roem. & Schult. (Apocynaceae), popularly known as "arrebenta-boi" and "paratudo". In behavioral screening ethanol extract of R. ligustrina roots demonstrated depressant effect on the CNS and anticonvulsant properties. The purpose of this study was to characterize the putative anxiolytic-like effects of the ethanol extract of Rauvolfia ligustrina roots (EER) using the elevated plus maze (EPM) and the hole-board apparatus in rodents. This extract, administered intraperitoneally, in different doses (3.9, 7.8 and 15.6 mg/kg) was able to increase significantly the number of entries (p < 0.05), as well as the time spent in the open arms of the EPM, indicating an anxiolytic-like effect. Additionally, EER-treated (3.9 and 7.8 mg/kg) increased significantly the number of border visit and head-dipping. This data suggest an anxiolytic effect of EER in animal models of anxiety. |
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Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board testsRauvolfia ligustrinaApocynaceaemedicinal plantanxiolyticplus-mazehole board testRauvolfia ligustrina Willd. ex Roem. & Schult. (Apocynaceae), popularly known as "arrebenta-boi" and "paratudo". In behavioral screening ethanol extract of R. ligustrina roots demonstrated depressant effect on the CNS and anticonvulsant properties. The purpose of this study was to characterize the putative anxiolytic-like effects of the ethanol extract of Rauvolfia ligustrina roots (EER) using the elevated plus maze (EPM) and the hole-board apparatus in rodents. This extract, administered intraperitoneally, in different doses (3.9, 7.8 and 15.6 mg/kg) was able to increase significantly the number of entries (p < 0.05), as well as the time spent in the open arms of the EPM, indicating an anxiolytic-like effect. Additionally, EER-treated (3.9 and 7.8 mg/kg) increased significantly the number of border visit and head-dipping. This data suggest an anxiolytic effect of EER in animal models of anxiety.Sociedade Brasileira de Farmacognosia2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000600017Revista Brasileira de Farmacognosia v.19 n.4 2009reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2009000600017info:eu-repo/semantics/openAccessMendonça Netto,SueliWarela,Rogério W. B.Fechine,Madge F.Queiroga,Marcelo N.Quintans-Júnior,Lucindo J.eng2010-05-19T00:00:00Zoai:scielo:S0102-695X2009000600017Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2010-05-19T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
| dc.title.none.fl_str_mv |
Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests |
| title |
Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests |
| spellingShingle |
Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests Mendonça Netto,Sueli Rauvolfia ligustrina Apocynaceae medicinal plant anxiolytic plus-maze hole board test |
| title_short |
Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests |
| title_full |
Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests |
| title_fullStr |
Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests |
| title_full_unstemmed |
Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests |
| title_sort |
Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests |
| author |
Mendonça Netto,Sueli |
| author_facet |
Mendonça Netto,Sueli Warela,Rogério W. B. Fechine,Madge F. Queiroga,Marcelo N. Quintans-Júnior,Lucindo J. |
| author_role |
author |
| author2 |
Warela,Rogério W. B. Fechine,Madge F. Queiroga,Marcelo N. Quintans-Júnior,Lucindo J. |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Mendonça Netto,Sueli Warela,Rogério W. B. Fechine,Madge F. Queiroga,Marcelo N. Quintans-Júnior,Lucindo J. |
| dc.subject.por.fl_str_mv |
Rauvolfia ligustrina Apocynaceae medicinal plant anxiolytic plus-maze hole board test |
| topic |
Rauvolfia ligustrina Apocynaceae medicinal plant anxiolytic plus-maze hole board test |
| description |
Rauvolfia ligustrina Willd. ex Roem. & Schult. (Apocynaceae), popularly known as "arrebenta-boi" and "paratudo". In behavioral screening ethanol extract of R. ligustrina roots demonstrated depressant effect on the CNS and anticonvulsant properties. The purpose of this study was to characterize the putative anxiolytic-like effects of the ethanol extract of Rauvolfia ligustrina roots (EER) using the elevated plus maze (EPM) and the hole-board apparatus in rodents. This extract, administered intraperitoneally, in different doses (3.9, 7.8 and 15.6 mg/kg) was able to increase significantly the number of entries (p < 0.05), as well as the time spent in the open arms of the EPM, indicating an anxiolytic-like effect. Additionally, EER-treated (3.9 and 7.8 mg/kg) increased significantly the number of border visit and head-dipping. This data suggest an anxiolytic effect of EER in animal models of anxiety. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009-12-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000600017 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000600017 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.1590/S0102-695X2009000600017 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
text/html |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
| publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
| dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.19 n.4 2009 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
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Sociedade Brasileira de Farmacognosia (SBFgnosia) |
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SBFGNOSIA |
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SBFGNOSIA |
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Revista Brasileira de Farmacognosia (Online) |
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Revista Brasileira de Farmacognosia (Online) |
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Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
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rbgnosia@ltf.ufpb.br |
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1752122463881265152 |