Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000400016 |
Resumo: | Current therapeutic for the treatment of anxiety is associated with a wild variety of side effects. The traditional use of plant extract to health care can indicate an important source of new pharmaceuticals. Bowdichia virgilioides Kunth, Fabaceae, is a plant commonly employed in the Brazilian folk medicine to treat inflammatory conditions. Nevertheless, despite its popular use there are no studies related to its possible neuropharmacological effect. Here, we investigated the possible anxiolytic effect of the extract of B. virgilioides after acute and sub-chronic treatment in mice. The aqueous extract from the stem barks of B. virgilioides (20, 200 or 400 mg/kg) was orally administered, and its anxiolytic effect was evaluated in the elevated plus maze, open-field and rota-rod tests. Diazepam was employed as standard drug. The aqueous extract treatment was effective in inducing anxiolytic effects with single acute treatment, a phenomenon that remained after chronic treatment. However, no changes in spontaneous locomotor activity or myorelaxant effect after aqueous extract treatment. The extract was either safe with no deaths in mice treated orally with 1000 mg/kg. These findings suggest that the aqueous extract from the stem barks of Bowdichia virgilioides has an acute and sub-chronic anxiolytic-like effect without compromising motor activity, demonstrating an advantage regarding to antidepressant drugs. |
id |
SBFGNOSIA-1_97be373f61a26de70da5e6d96e1b976b |
---|---|
oai_identifier_str |
oai:scielo:S0102-695X2013000400016 |
network_acronym_str |
SBFGNOSIA-1 |
network_name_str |
Revista Brasileira de Farmacognosia (Online) |
repository_id_str |
|
spelling |
Anxiolytic-like effect of the extract from Bowdichia virgilioides in miceBowdichia virgilioidesanxietyelevated plus mazeopen fieldrota rodCurrent therapeutic for the treatment of anxiety is associated with a wild variety of side effects. The traditional use of plant extract to health care can indicate an important source of new pharmaceuticals. Bowdichia virgilioides Kunth, Fabaceae, is a plant commonly employed in the Brazilian folk medicine to treat inflammatory conditions. Nevertheless, despite its popular use there are no studies related to its possible neuropharmacological effect. Here, we investigated the possible anxiolytic effect of the extract of B. virgilioides after acute and sub-chronic treatment in mice. The aqueous extract from the stem barks of B. virgilioides (20, 200 or 400 mg/kg) was orally administered, and its anxiolytic effect was evaluated in the elevated plus maze, open-field and rota-rod tests. Diazepam was employed as standard drug. The aqueous extract treatment was effective in inducing anxiolytic effects with single acute treatment, a phenomenon that remained after chronic treatment. However, no changes in spontaneous locomotor activity or myorelaxant effect after aqueous extract treatment. The extract was either safe with no deaths in mice treated orally with 1000 mg/kg. These findings suggest that the aqueous extract from the stem barks of Bowdichia virgilioides has an acute and sub-chronic anxiolytic-like effect without compromising motor activity, demonstrating an advantage regarding to antidepressant drugs.Sociedade Brasileira de Farmacognosia2013-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000400016Revista Brasileira de Farmacognosia v.23 n.4 2013reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2013005000044info:eu-repo/semantics/openAccessVieira,Larissa Fernanda de A.Reis,Maria Danielma dos S.Brandão,Altair Rogério A.Viana,Iana Mayane M. N.Silva,Juliane Pereira daBarreto,EmilianoSmaniotto,Saleteeng2013-09-23T00:00:00Zoai:scielo:S0102-695X2013000400016Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2013-09-23T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice |
title |
Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice |
spellingShingle |
Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice Vieira,Larissa Fernanda de A. Bowdichia virgilioides anxiety elevated plus maze open field rota rod |
title_short |
Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice |
title_full |
Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice |
title_fullStr |
Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice |
title_full_unstemmed |
Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice |
title_sort |
Anxiolytic-like effect of the extract from Bowdichia virgilioides in mice |
author |
Vieira,Larissa Fernanda de A. |
author_facet |
Vieira,Larissa Fernanda de A. Reis,Maria Danielma dos S. Brandão,Altair Rogério A. Viana,Iana Mayane M. N. Silva,Juliane Pereira da Barreto,Emiliano Smaniotto,Salete |
author_role |
author |
author2 |
Reis,Maria Danielma dos S. Brandão,Altair Rogério A. Viana,Iana Mayane M. N. Silva,Juliane Pereira da Barreto,Emiliano Smaniotto,Salete |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Vieira,Larissa Fernanda de A. Reis,Maria Danielma dos S. Brandão,Altair Rogério A. Viana,Iana Mayane M. N. Silva,Juliane Pereira da Barreto,Emiliano Smaniotto,Salete |
dc.subject.por.fl_str_mv |
Bowdichia virgilioides anxiety elevated plus maze open field rota rod |
topic |
Bowdichia virgilioides anxiety elevated plus maze open field rota rod |
description |
Current therapeutic for the treatment of anxiety is associated with a wild variety of side effects. The traditional use of plant extract to health care can indicate an important source of new pharmaceuticals. Bowdichia virgilioides Kunth, Fabaceae, is a plant commonly employed in the Brazilian folk medicine to treat inflammatory conditions. Nevertheless, despite its popular use there are no studies related to its possible neuropharmacological effect. Here, we investigated the possible anxiolytic effect of the extract of B. virgilioides after acute and sub-chronic treatment in mice. The aqueous extract from the stem barks of B. virgilioides (20, 200 or 400 mg/kg) was orally administered, and its anxiolytic effect was evaluated in the elevated plus maze, open-field and rota-rod tests. Diazepam was employed as standard drug. The aqueous extract treatment was effective in inducing anxiolytic effects with single acute treatment, a phenomenon that remained after chronic treatment. However, no changes in spontaneous locomotor activity or myorelaxant effect after aqueous extract treatment. The extract was either safe with no deaths in mice treated orally with 1000 mg/kg. These findings suggest that the aqueous extract from the stem barks of Bowdichia virgilioides has an acute and sub-chronic anxiolytic-like effect without compromising motor activity, demonstrating an advantage regarding to antidepressant drugs. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000400016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000400016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2013005000044 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.23 n.4 2013 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122468773920768 |