Detalhes bibliográficos
| Autor(a) principal: |
Schoenfelder,Tatiana |
| Data de Publicação: |
2010 |
| Outros Autores: |
Warmlin,Carolini Z.,
Manfredini,Michele S.,
Pavei,Larissa L.,
Réus,Juana V.,
Tristão,Taciane C.,
Fernandes,Marcelo S.,
Costa-Campos,Luciane |
| Tipo de documento: |
Artigo
|
| Idioma: |
eng |
| Título da fonte: |
Revista Brasileira de Farmacognosia (Online) |
| Texto Completo: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000200014
|
Resumo: |
Ethanolic crude extract (ECE) of leaves from Syzygium cumini (L.) Skeels, Myrtaceae was screened for its hypoglycemic and hypolipidemic activity (125, 250 and 500 mg/kg v.o.). Rats were divided into three groups for the evaluation of the hypoglycemic effect: normal rats, rats with alloxan-induced diabetes and hyperglycemic normal rats. Hypolipidemia was evaluated in rats with alloxan-induced diabetes. The antihyperglycemic activity was compared to treatment with glibenclamide, an oral hypoglycemic agent. The acute treatment with S. cumini ECE caused a significant decrease in the blood glucose in hyperglycemic normal rats (250 mg/kg), and in glucose (125 and 250 mg/kg), triglyceride (125 and 500 mg/kg) and cholesterol (125 mg/kg) levels of diabetic rats, but no effect was observed in the normal treated rats. Syzygium cumini leaves are a good candidate for alternative and/or complementary medicine in the management of diabetes mellitus, since they showed hypoglycemic activity in addition to a hypolipidemic action in diabetic animals. |